Jean Félix Peko

Marien Ngouabi University

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Anicet Luc Magloire Boumba

Marien Ngouabi University

Dimitry Moudiongui Mboungou Malanda

Centre Hospitalier et Universitaire de Brazzaville

Donatien Moukassa

Marien Ngouabi University

Gervillien Arnold Malonga

Assistance Publique – Hôpitaux de Paris

Henriette Poaty

Marien Ngouabi University

Anne‐Geneviève Marcelin

Sorbonne Université

J. C. Mokoko

Marien Ngouabi University

Charles Gombé Mbalawa

Centre Hospitalier et Universitaire de Brazzaville

A N'Golet

Centre Hospitalier et Universitaire de Brazzaville

Vincent Cálvez

Sorbonne Université

Cooperative Institutions

Centre Hospitalier et Universitaire de Brazzaville

Marien Ngouabi University

Inserm

Wildlife Conservation Society Congo

Sorbonne Université

Assistance Publique – Hôpitaux de Paris

Centre National de la Recherche Scientifique

Université Paris Cité

Institut Pierre Louis d‘Épidémiologie et de Santé Publique

Pitié-Salpêtrière Hospital

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Genome-Wide High-Resolution aCGH Analysis of Gestational Choriocarcinomas

PLoS ONE (2012)

Henriette Poaty Philippe Coullin Jean Félix Peko Philippe Dessen Ange Lucien Diatta

Eleven samples of DNA from choriocarcinomas were studied by high resolution CGH-array 244 K. They were studied after histopathological confirmation of the diagnosis, of the androgenic etiology and after a microsatellite marker analysis confirming the absence of contamination of tumor DNA from maternal DNA. Three cell lines, BeWo, JAR, JEG were also studied by this high resolution pangenomic technique. According to aCGH analysis, the de novo choriocarcinomas exhibited simple chromosomal rearrangements or normal profiles. The cell lines showed various and complex chromosomal aberrations. 23 Minimal Critical Regions were defined that allowed us to list the genes that were potentially implicated. Among them, unusually high numbers of microRNA clusters and imprinted genes were observed.

Comparative genomic hybridization

Genomic Imprinting

10.1371/journal.pone.0029426

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Citations (30)

Seroprevalence of Crimean-Congo hemorrhagic fever virus among people living with HIV in Brazzaville, Congo and among blood donors in Bamako, Mali

Ticks and Tick-borne Diseases (2023)

Gervillien Arnold Malonga Almoustapha Issiaka Maïga Dimitry Moudiongui Mboungou Malanda Mahamadou Saliou Juthèce Private Malanda-Kiminou

Crimean-Congo hemorrhagic fever virus (CCHFV) is the causative agent of Crimean-Congo hemorrhagic fever (CCHF), a highly contagious and potentially fatal emerging disease. We assessed CCHFV seroprevalence by conducting a serological survey of two cohorts from Brazzaville, Congo and Bamako, Mali. We retrospectively screened 581 sera samples, including 352 from monitoring centers for people living with HIV (PLWH) in Brazzaville and 229 provided by the Blood Transfusion Center at Gabriel Touré Hospital in Bamako. An ELISA kit (ID Screen® CCHF Double Antigen Multi-species, Innovative Diagnostics) was used to detect total anti-CCHFV antibodies in serum. CCHFV seroprevalence was 0.6% in the PLWH cohort in Brazzaville, all in a peri‑urban area near livestock/agriculture, and 1.75% in a cohort of blood donors in Bamako, half living in a peri‑urban area near livestock/agriculture and the others performing risk-exposure activities, such as working as a butcher or with frequent rural travels. PLWH from Brazzaville were mostly female, older, and more highly educated, with a tertiary sector activity and living in an urban biotope without livestock/agricultural activities in the surroundings, in contrast to the blood donors of Bamako, who were younger and more likely to live in peri‑urban/rural areas with livestock/agricultural activities in the surroundings. Despite a low CCHFV seroprevalence, our study indicates human contact with CCHFV in sub-urban areas of the capital cities of Congo and Mali associated with previously described CCHFV risk factors.

Seroprevalence

Crimean–Congo hemorrhagic fever

10.1016/j.ttbdis.2023.102276

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Citations (1)

Rémission complète d’un sarcome intratesticulaire

ONCOLOGIE (2009)

Judith Nsondé Malanda Jean Félix Peko Charles Gombé Mbalawa

10.1007/s10269-008-1040-y

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Molecular Signature of Human Papillomavirus in Upper Aerodigestive Tract Cancers in Congo-Brazzaville

International Journal of Pathogen Research (2021)

Anicet Luc Magloire Boumba Sylvain Diembi Boris Otouana G. C. Gouoni A. B. Ecokounda Okoko

Introduction: Carcinomas of the upper aerodigestive tract have a tropism on the epidermoid mucosa. HPV infection remains one of the risk factors for this cancer. This work aimed to study the presence of human papillomavirus (HPV) in carcinomas of the VADS. Materials and Methods: This was a cross-sectional descriptive and analytical study with retrospective data collection over 7 years. The molecular analysis was conducted in Pointe-Noire using Xpert® HPV technology (GeneXpert, Cepheid). The variables studied were anatomopathological and virological. Results: The overall molecular prevalence of oncogenic HPV was 28.1%. HPV-16 and HPV-18/45 were the incriminating genotypes in 88.9% and 11.4% of cases, respectively. A statistically significant association was found between co-infection with HPV-oncogenes in subjects over 40 years of age (P=0.01) and the development of these HPVs in squamous cell carcinomas (p=0.02). Notably, oncogenic HPV was found in the majority of laryngeal carcinomas. Conclusion: In countries with limited resources, the Xpert HPV technology from GéneXpert is a reliable and rapid solution for the virological diagnosis of oncogenic HPV associated with carcinomas of the VADS. HPV-16 remains the most prevalent genotype.

10.9734/ijpr/2021/v7i330182

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Torsion de tumeur kystique de l’ovaire chez une adolescente, révélatrice d’un hémangiome caverneux

Archives de Pédiatrie (2003)

Anne Berthe M’pemba Loufoua-Lemay Jean Félix Peko Jean Alfred Mbongo J. C. Mokoko S Nzingoula

Angioma

10.1016/j.arcped.2003.08.007

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Citations (12)

Profil des affections orbitaires au Centre Hospitalier et Universitaire de Brazzaville, Congo

Journal Français d Ophtalmologie (2006)

Gizem Kaya C. Makita Bagamboula Jean Félix Peko J Silou L. Manvouri

Etiology

10.1016/s0181-5512(06)73784-6

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Citations (5)

Seroprevalence of Crimean-Congo Hemorrhagic Fever Virus Among People Living with HIV in Brazzaville, Congo and Among Blood Donors in Bamako, Mali

Gervillien Arnold Malonga Almoustapha Issiaka Maïga Dimitry Moudiongui Mboungou Malanda Mahamadou Saliou Juthèce Private Malanda-Kiminou

Crimean-Congo hemorrhagic fever virus (CCHFV) is the causative agent of Crimean-Congo Hemorrhagic Fever (CCHF) which is a highly contagious and potentially fatal emerging disease. To assess the CCHFV seroprevalence, we conducted a serological survey in two cohorts from Brazzaville, Congo and from Bamako, Mali. We retrospectively screened 581 samples including 352 sera from monitoring centers for people living with HIV (PLWH) in Brazzaville and 229 sera provided by the Blood Transfusion Center at Gabriel Touré Hospital. ELISA Kit (ID Screen® CCHF Double Antigen Multi-species, Innovative Diagnostics) was used to detect anti-CCHFV total antibodies in serum. CCHFV seroprevalence was 0.6% in the PLWH cohort in Brazzaville, all in peri-urban area near to livestock/agriculture; and 1.75% in Bamako blood donor’s cohort, half of them living in peri-urban area near to livestock/agriculture and the others with risk-exposure activities as working as slaughter or frequent rural travels. PLWH from Brazzaville were mostly female, older, more educated with a tertiary sector activity and lived in an urban biotope without livestock/agricultural activities in the surroundings, in contrast with the blood donors of Bamako, which were younger and more prompted to live in peri-urban/rural areas with livestock/agricultural activities in the surroundings. Despite a low CCHFV seroprevalence, our study indicates a potential human contact with CCHFV in sub-urban areas of the capital cities of Congo and Mali, associated to previously described CCHFV risk-factors.

Seroprevalence

Crimean–Congo hemorrhagic fever

10.2139/ssrn.4399512

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Citations (0)

BMPR1A and SMAD4 mutations in juvenile polyposis syndrome: clinicopathological and genetic data from two congolese patients

Gene Reports (2021)

Henriette Poaty Lauria Batamba Bouya Irène Patricia Lucienne Ondima Arnaud Mongo‐Onkouo Aimé Lumaka

Juvenile polyposis syndrome (JPS) is a rare genetic disorder due to germline mutations in BMPR1A or in SMAD4 that are both tumor suppressor genes. The main clinical manifestation is the presence of multiple hamartomatous polyps preferentially located in gastrointestinal tract, mostly in colorectal site. The polyps can degenerate and lead to inherited malignant tumors. Among 3157 patients with malignant and benign tumors diagnosed in Brazzaville teaching hospital, 43 persons with polyposis in colorectal tube were recruited. The positive diagnosis was based on endoscopic examination, World Health Organization and JASS guidelines clinical criteria, histopathological analysis and next-generationsequencing of DNAs extracted from peripheral blood of the patients. Among 43 patients having polyposis, two were male patients identified with JPS representing 4.65% of polyposis and 0.06% of all tumors. Histological examination revealed typical JPS features. In those two males, whole genome comparative microarray did not identify relevant copy number imbalances. DNA sequencing of a comprehensive gene cancer genes panel identified specific mutations in the BMPR1A and SMAD4 genes. We have shown that BMPR1A and SMAD4 gene disorders are responsible for JPS in congolese patients as well and a novel mutation has been identified in one individual. As the condition predisposes highly to hereditary colorectal cancer, a comprehensive assessment of the JPS including genetic testing should be implemented in order to facilitate early diagnosis in Congo Brazzaville.

10.1016/j.genrep.2021.101141

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Citations (4)

Early diagnosis by PCR of HIV1 in children before 18 months born to HIV-positive mothers in Brazzaville

East African Medical Journal (2019)

Gervillien Arnold Malonga L. M. E. Eouani J. C. Mokoko N.Y. Ngakengni G.L.E. Missamou

Objective: To contribute for improving the care of children before 18 months, born to HIV mothers by early diagnosis of HIV-1 by RT/PCR.Methods: analytical cross-sectional study carried out at the Ambulatory Treatment Center (ATC) for people living with HIV and at the National Public Health Laboratory of Brazzaville, from January 1, 2010 to 30 June 2018. The study population was made up of pregnant women included in the Prevention of Mother-to-Child Transmission (PMTCT) program and who gave birth to one or more children during that period, their children having the results of the PCR1 available. The tests were statistically significant when the p-value was less than 0.05.Results: Eighty-six children whose mothers were followed by PMTCT program were screened, of which 5 had a positive PCR and 81 negatives, either 5.8% of the residual transmission rate of HIV-1. The most common age group was between 38 and 47 years (70.9%). They were 58.8% unemployed with a 1st level secondary school level (53.2) and 57.8% single. The rate of CD4 was superior to 350 copies in 65.1%, and the viral load was undetectable in 66.3%. Deliveries were performed vaginally in 79.1% and newborn had received 57% of artificial breastfeeding. Among children, boys represented 59.3% with 40.7% girls, either 1,4 of ratio sex. The bivariate analysis between the results of the PCR and the child’s weight had not shown any significant difference (p >0.05). The newborns were eutrophic so 97.5% of cases including the 5 positive cases of PCR. Among newborns, 69.5% had their PCR results within 60 days of delivery.

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Mélanomes malins primitifs extracutanés à Brazzaville

Journal africain du cancer / African Journal of Cancer (2009)

Judith Nsondé Malanda Jean Bernard Nkoua Mbon Jean Félix Peko Y. Datsé J. Kokolo

10.1007/s12558-008-0004-x

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Citations (1)