V.K. Bhargava

University of Delhi

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R.H. Iyer

Bhabha Atomic Research Centre

V.K. Rao

Sahyadri Hospital

S. G. Marathe

Bhabha Atomic Research Centre

P Pandhi

Post Graduate Institute of Medical Education and Research

S. M. Sahakundu

Bhabha Atomic Research Centre

H.S. Kamath

Manipal Academy of Higher Education

R S Karan

Kasturba Medical College, Mangalore

M.V. Ramaniah

Bhabha Atomic Research Centre

S K Garg

Dayanand Medical College & Hospital

S. Balakrishnan

Sanjay Gandhi Post Graduate Institute of Medical Sciences

Cooperative Institutions

Vehicle Technologies Office

115

Post Graduate Institute of Medical Education and Research

Bhabha Atomic Research Centre

University College London

Charité - Universitätsmedizin Berlin

Universität Hamburg

University of Delhi

All India Institute of Medical Sciences

Inserm

Banaras Hindu University

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Determination of hexavalent plutonium using differential spectrophotometry

Journal of Radioanalytical and Nuclear Chemistry (1989)

V.K. Bhargava G. Chourasiya D. R. Ghadse U. M. Kasar M. S. Oak

Absorbance

Spectrophotometry

10.1007/bf02060990

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Citations (1)

Search for low-yield products in the neutron-induced highly asymmetric fission of uranium

Physical Review C (1974)

V.K. Rao V.K. Bhargava S. G. Marathe S. M. Sahakundu R.H. Iyer

The results of investigations aimed at defining the nature of mass distribution in the reactor neutron-induced highly asymmetric binary fission of natural, depleted, and enriched uranium are presented. Fission yields of mass chains 66, 67, 72, 77, 161, 172, 175, 177 were determined relative to $^{99}\mathrm{Mo}$ using radiochemical methods. Upper limits for the yields of $^{183}\mathrm{Ta}$ and $^{199}\mathrm{Au}$ were also set to see the trend of mass distribution beyond $A=177$. As expected the yields of highly asymmetric products in the region $A<70$ and $A>161$ are sensitive to the excitation energy of the fissioning nucleus, a trend observed in symmetric fission. Computer extrapolation of the yields up to $A=180$ on the heavier side and $A=60$ on the lighter side indicates that both wings of the mass-yield curve cannot be represented by a single Gaussian, thereby disturbing the complementarity of the mass-yield curve in the highly asymmetric region. The relatively higher yields for mass regions around $A=67 \mathrm{and} 177$, together with the upper limits for $A=183 \mathrm{and} 199$ in the reactor neutron fission of $^{238}\mathrm{U}$, tend to suggest the possibility of shoulders in the low-yield wings of the mass-yield curve.

Mass distribution

Uranium-235

Spontaneous fission

10.1103/physrevc.9.1506

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Citations (14)

Tolerance and withdrawal to anticonvulsant action of clonazepam: Role of nitric oxide

Methods and Findings in Experimental and Clinical Pharmacology (2000)

Nishkarsh Gupta V.K. Bhargava P Pandhi

The use of clonazepam in the long-term treatment of epilepsy is greatly inhibited by its capacity to induce tolerance and dependence. A means of preventing or minimizing the tolerance and dependence inducing properties is required. Here the role of nitric oxide in preventing the development of tolerance and withdrawal hyperexcitability was studied. In Wistar rats, clonazepam at a dose of 0.25 mg/kg i.p. twice daily produced tolerance to its anticonvulsant action in 28 days. After sudden cessation of therapy it produced hyperexcitability. Tolerance was shown by a decrease in seizure threshold to near control value while withdrawal hyperexcitability was evidenced by a significant decrease in seizure threshold below the control value. L-Arginine (a donor of nitric oxide) and N omega-nitro-L-arginine (an inhibitor of nitric oxide synthase) were given in doses of 150 mg/kg and 8 mg/kg, respectively on day 1, 3, 7, 14, 21 and 28 with clonazepam. Withdrawal hyperexcitability was seen on day 1, 2 and 4 after cessation of drug therapy. Electroshock was used as a model of epilepsy and seizure thresholds were determined by an up and down method of Kimball et al. L-Arginine was found to inhibit the development tolerance as well as withdrawal hyperexcitability when administered with clonazepam while N omega-L-arginine did not prevent either the development of tolerance or withdrawal hyperexcitability in the electroshock model. In the PTZ model, however, L-arginine had no effect on the anticonvulsant action and withdrawal hyperexcitability while inhibition of nitric oxide synthesis prevented withdrawal hyperexcitability in PTZ-induced seizures.

Clonazepam

Seizure threshold

Drug tolerance

10.1358/mf.2000.22.4.584455

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Cutaneous adverse reactions in in-patients in a tertiary care hospital.

PubMed (1999)

Ratinder Jhaj R Uppal S. Malhotra V.K. Bhargava

Cutaneous reactions were monitored by spontaneous adverse reaction monitoring system among inpatients in Nehru Hospital, over a period of 3 1/2 years. A total of 379 adverse drug reactions were reported during this period, of which 144 (40%) were cutaneous reactions. Maculopapular rashes (50% of cutaneous reactions), and urticaria (21.5%) were the most common eruption. Stevens-Johnson syndrome (13.9%) and toxic epidermal necrolysis (TEN 4.9%) were the serious cutaneous reactions. There were 4 fatal cutaneous reactions (all due to TEN). Antimicrobials (caused 56.9% reactions), radiocontrast dyes (14.6% reactions) and antiepileptics (15.3% reactions) were the most prominent drugs responsible for these eruptions.

Toxic Epidermal Necrolysis

Drug reaction

Skin reaction

Tertiary care

Adverse drug reaction

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Citations (40)

Adverse drug reactions to fluoroquinolones in pediatric patients in a tertiary care hospital.

PubMed (2000)

K.H. Reeta R Uppal Ratinder Jhaj Supriya Deepak Malhotra V.K. Bhargava

Tertiary care

Drug reaction

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Influence of kinnow juice on the pharmacokinetics of sustained release theophylline in healthy male volunteers.

PubMed (2000)

Monika Gupta S K Garg V.K. Bhargava

The effect of kinnow juice on the pharmacokinetics of a single dose of sustained release theophylline was investigated in healthy male volunteers. In a two phased open cross-over randomized study, ten healthy male volunteers were given sustained release theophylline (300 mg) along with 300 ml of water or kinnow juice, a routinely used citrus juice in India. Blood samples were collected at different time points from 0-48 hours. Plasma was assayed for theophylline by a HPLC method and various pharmacokinetic parameters were calculated and compared. The theophylline levels were lower at all the time points with kinnow juice co-administration as compared to water but were significantly so only during the absorption phase from 1-4 hours. The values for all the pharmacokinetic parameters evaluated were on the lower side with kinnow juice except Tmax which was slightly delayed. None of these alterations was found to be significantly different. The results indicate that since there is an interference with the absorption of the drug, the patients may be advised not to consume kinnow juice when taking a slow release theophylline preparation and the monitoring of plasma concentrations of theophylline in patients who routinely consume kinnow juice in their diet might be helpful in better management of these patients.

Grapefruit juice

Fruit juice

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Effect of 'Mentat' on the pharmacokinetics of single and multiple doses o phenytoin in rabbits.

PubMed (1999)

S K Garg Aminul Islam Nitin Kumar Mukul Sehgal V.K. Bhargava

The effect of 'Mentat', a herbal preparation, was studied on pharmacokinetics of single and multiple doses of phenytoin in rabbits. No significant effect was found after single oral dose of 'Mentat' on single dose kinetics of phenytoin. However, 'Mentat' administration for 7 days increased the steady state kinetic parameters. Peak plasma phenytoin concentration, area under the implasma concentration and elimination half life were significantly increased and t-max was significantly reduced, indicating the suppression of phenytoin metabolism by 'Mentat'.

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Pharmacokinetics of ciprofloxacin in patients with liver cirrhosis.

PubMed (2002)

Ruhi Dixit Sanjaya K. Satapathy Ratnesh Kumar RK Dhiman Sandeep Garg

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Effect of melatonin and beta-carotene on indomethacin induced gastric mucosal injury.

PubMed (2002)

Priya Singh V.K. Bhargava Sanjay K. Garg

The study was conducted to examine the role of free radicals in Indomethacin induced gastric mucosal injury and to evaluate the gastroprotective effects of melatonin and beta-carotene. Gastric mucosal injury was produced in rats by administering indomethacin 30 mg/kg subcutaneously. Melatonin was administered in three different doses of 5, 10 and 20 mg/kg, 30 minutes prior to the administration of indomethacin. Beta-carotene was administered as a single dose of 100 mg/kg. Following parameters were calculated: ulcer index, lipid peroxidation and antioxidant defense enzymes i.e. superoxide dismutase, glutathione peroxidase and catalase. Indomethacin caused gastric mucosal injury in the form of haemorrhages, increased the lipid peroxidation and decreased the levels of the antioxidant defense enzymes. Melatonin (20 mg/kg) and beta-carotene decreased the ulcer index and lipid peroxidation, and reduced the decrease in antioxidant enzyme levels. These findings suggest the melatonin and beta-carotene show protective effect against indomethacin induced gastric injury and this effect is mediated by scavenging of oxygen derived free radicals.

Ulcer index

Malondialdehyde

beta-Carotene

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Citations (17)

In-line analytical methods for fuel reprocessing streams. Part III. Gamma monitoring of fission products

S. G. Marathe V.K. Bhargava V.K. Rao R.H. Iyer M.V. Ramaniah

Long-lived fission product

Line (geometry)

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