Gyeong Jin Park

Hanyang University

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Cheal Kim

Seoul National University of Science and Technology

Seul Ah Lee

Chosun University

Jae Jun Lee

Seoul National University of Science and Technology

Hyun Yong Jo

Seoul National University of Science and Technology

Ga Rim You

Seoul National University of Science and Technology

Yu Jeong Na

Seoul National University of Science and Technology

Ye Won Choi

Pusan National University

Youngmee Kim

Ewha Womans University

Insup Noh

Seoul National University of Science and Technology

Sung‐Jin Kim

Chungnam National University

Cooperative Institutions

Seoul National University of Science and Technology

Government of the Republic of Korea

Seoul National University

University of Michigan–Ann Arbor

Ewha Womans University

Korea University

Korea Institute of Science and Technology

Ewha Womans University Medical Center

Korea University of Science and Technology

Korea Advanced Institute of Science and Technology

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A colorimetric chemosensor for the sequential detection of copper ion and amino acids (cysteine and histidine) in aqueous solution

RSC Advances (2015)

Yong‐Sung Kim Gyeong Jin Park Seul Ah Lee Cheal Kim

A simple and selective colorimetric chemosensor was reported for the sequential detection of Cu²⁺, cysteine and histidine.

Colorimetry

Aqueous medium

10.1039/c5ra00544b

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Citations (65)

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains

Nature Communications (2015)

Hanseong Kim Sojin An Seung‐Hyun Ro Filipa Teixeira Gyeong Jin Park

Abstract Sestrins are stress-inducible metabolic regulators with two seemingly unrelated but physiologically important functions: reduction of reactive oxygen species (ROS) and inhibition of the mechanistic target of rapamycin complex 1 (mTORC1). How Sestrins fulfil this dual role has remained elusive so far. Here we report the crystal structure of human Sestrin2 (hSesn2), and show that hSesn2 is twofold pseudo-symmetric with two globular subdomains, which are structurally similar but functionally distinct from each other. While the N-terminal domain (Sesn-A) reduces alkylhydroperoxide radicals through its helix–turn–helix oxidoreductase motif, the C-terminal domain (Sesn-C) modified this motif to accommodate physical interaction with GATOR2 and subsequent inhibition of mTORC1. These findings clarify the molecular mechanism of how Sestrins can attenuate degenerative processes such as aging and diabetes by acting as a simultaneous inhibitor of ROS accumulation and mTORC1 activation.

10.1038/ncomms10025

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Citations (131)

CCDC 978432: Experimental Crystal Structure Determination

The Cambridge Structural Database (2015)

Wei Wang Young Ae Lee Gyeongwon Kim Seog K. Kim Ga Ye Lee

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/cc11v4bc

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CCDC 1001739: Experimental Crystal Structure Determination

The Cambridge Structural Database (2015)

Gyeong Jin Park Dae Yul Park Kyung‐Min Park Youngmee Kim Sung‐Jin Kim

10.5517/cc12md58

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An asymmetric naked-eye chemo-sensor for Cu2+ in aqueous solution

Inorganic Chemistry Communications (2014)

Hyun Yong Jo Gyeong Jin Park Kwon Hee Bok Kyung‐Min Park Pahn‐Shick Chang

Naked eye

10.1016/j.inoche.2014.11.016

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A single molecule that acts as a fluorescence sensor for zinc and cadmium and a colorimetric sensor for cobalt

Dalton Transactions (2013)

Eun Joo Song Juhye Kang Ga Rim You Gyeong Jin Park Youngmee Kim

A new metal ion sensor that contains quinoline and pyridylaminophenol has been synthesized. In acetonitrile and in the presence of Zn2+, the sensor fluoresces. In contrast, in aqueous solutions the sensor fluoresces in the presence of Cd2+. The fluorescence of the molecule is selective for Zn2+ or Cd2+ and shows no fluorescence with other metal ions. The crystal structure of the Cd2+ complex shows coordination through the amide and phenol oxygens, as well as the amine nitrogen of the sensor. The sensor also acts as a colorimetric sensor for Co2+ by changing color from colorless to yellow. The color change is selective for Co2+ and is not observed with other metal ions. The unique combination of pyridine and phenol groups with quinoline results in the properties of this sensor.

Quinoline

Amide

10.1039/c3dt51635k

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Citations (138)

A colorimetric organic chemo-sensor for Co²⁺in a fully aqueous environment

Dalton Transactions (2014)

Gyeong Jin Park Yu Jeong Na Hyun Yong Jo Seul Ah Lee Cheal Kim

A novel practical “naked eye” probe for Co²⁺in a fully aqueous solution has been developed.

10.1039/c4dt00423j

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Citations (68)