Alan M. Dyke

Johnson Matthey (United Kingdom)

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Guy C. Lloyd‐Jones

University of Edinburgh

Antonio Zanotti‐Gerosa

Johnson Matthey (United Kingdom)

B. Engendahl

DSM (Netherlands)

Giancarlo Franciò

Universidade de Caxias do Sul

Alison J. Hester

James Hutton Institute

Thomas Pullmann

RWTH Aachen University

Walter Leitner

RWTH Aachen University

Ziyun Zhang

Shanghai Institute of Technology

D. Michael Gill

University of Huddersfield

J.P.H. Charmant

University of Bristol

Cooperative Institutions

University of Bristol

University of Surrey

Johnson Matthey (United Kingdom)

AstraZeneca (United Kingdom)

Loughborough University

RWTH Aachen University

University of Warwick

GlaxoSmithKline (United Kingdom)

University of St Andrews

University of Southampton

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Application of [BoPhoz Rh] catalysts in the asymmetric hydrogenation of a pyridyl benzothiophene alkene

Tetrahedron Letters (2011)

Timothy D. Gross Shine Chou Alan M. Dyke Beatriz Domínguez Michelle Groarke

Benzothiophene

Alkene

Asymmetric hydrogenation

10.1016/j.tetlet.2011.12.038

Cite

Citations (11)

New Quinaphos Ligands for Asymmetric Hydrogenation

Synfacts (2010)

Giancarlo Franciò Walter Leitner Thomas Pullmann B. Engendahl Zhan Zhang

New members of the Quinaphos-type ligands have been synthesized by a simple protocol and fully characterized. These new Quinaphos ligands with a more flexible 1,2,3,4-tetrahydroquinoline backbone were shown to be extremely effective for asymmetric hydrogenation of functionalized olefins, dehydroamino acid derivatives as well as enamides.

Asymmetric hydrogenation

10.1055/s-0030-1258692

Cite

Citations (0)

The anionic thia-Fries rearrangement of aryl triflates

Chemical Communications (2003)

J.P.H. Charmant Alan M. Dyke Guy C. Lloyd‐Jones

Aryl triflates undergo LDA-mediated rearrangement to generate o-hydroxyaryl trifluoromethylsulfones. In some cases, partitioning between rearrangement and aryne generation can be controlled.

Fries rearrangement

Aryne

10.1039/b210648e

Cite

Citations (60)

Organometallic Generation and Capture of ortho-Arynes

Synthesis (2006)

Guy C. Lloyd‐Jones Alan M. Dyke Alison J. Hester

This literature review focuses on the use of metal- or metalloid-based reagents to generate ortho-arynes from stable precursors via organometallic intermediates or to generate organometallic complexes of ortho-arynes. The review also encompasses the capture of arynes by organometallics to generate new complexes, with interesting reactivity in their own right, or as intermediates in catalytic systems. The purpose of the review is to highlight the novelty, utility and versatility of the interaction of organometallic species with arynes and their precursors. These points are illustrated through a number of examples of the application of such methods in the preparation of complex organic molecules. The review contains some 197 references and covers the literature up to May 2006.

Aryne

Reactivity

Metalloid

Organometallic Chemistry

10.1055/s-2006-950370

Cite

Citations (26)

CCDC 199494: Experimental Crystal Structure Determination

The Cambridge Structural Database (2005)

J.P.H. Charmant Alan M. Dyke Guy C. Lloyd‐Jones

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Crystal (programming language)

10.5517/cc6pl9r

Cite

Citations (0)

The Anionic Thia‐Fries Rearrangement of Aryl Triflates.

ChemInform (2003)

J.P.H. Charmant Alan M. Dyke Guy C. Lloyd‐Jones

Abstract For Abstract see ChemInform Abstract in Full Text.

Fries rearrangement

10.1002/chin.200323086

Cite

Citations (0)

Quinaphos and Dihydro‐Quinaphos Phosphine–Phosphoramidite Ligands for Asymmetric Hydrogenation

Chemistry - A European Journal (2010)

Thomas Pullmann B. Engendahl Ziyun Zhang Markus Hölscher Antonio Zanotti‐Gerosa

New derivatives of the Quinaphos ligands and the related Dihydro-Quinaphos ligands based on the more flexible 1,2,3,4-tetrahydroquinoline backbone have been prepared and fully characterised. A general and straightforward separation protocol was devised, which allowed for the gram-scale isolation of the R(a),S(c) and S(a),R(c) diastereomers. These new phosphine-phosphoramidite ligands have been applied in the Rh-catalysed asymmetric hydrogenation of functionalised olefins with the achievement of excellent enantioselectivities (> or = 99%) in most cases and turnover frequency (TOF) values of up to > or = 20,000 h(-1). These results substantiate the practical utility of readily accessible Quinaphos-type ligands, which belong to the most active and selective category of ligands for Rh-catalysed hydrogenation known to date.

Phosphoramidite

Asymmetric hydrogenation

Diastereomer

10.1002/chem.201000063

Cite

Citations (55)

CCDC 749795: Experimental Crystal Structure Determination

The Cambridge Structural Database (2010)

Thomas Pullmann B. Engendahl Ziyun Zhang M. Hölscher Antonio Zanotti‐Gerosa

10.5517/cct56y3

Cite

Citations (0)

Application of Tethered Ruthenium Catalysts to Asymmetric Hydrogenation of Ketones, and the Selective Hydrogenation of Aldehydes

Advanced Synthesis & Catalysis (2012)

Katherine E. Jolley Antonio Zanotti‐Gerosa Fred Hancock Alan M. Dyke D.M. Grainger

Abstract An improved method for the synthesis of tethered ruthenium(II) complexes of monosulfonylated diamines is described, together with their application to the hydrogenation of ketones and aldehydes. The complexes were applied directly, in their chloride form, to asymmetric ketone hydrogenation, to give products in excess of 99% ee in the best cases, using 30 bar of hydrogen at 60 °C, and to the selective reduction of aldehydes over other functional groups.

Noyori asymmetric hydrogenation

Asymmetric hydrogenation

Transfer hydrogenation

10.1002/adsc.201200362

Cite

Citations (82)

Decoupling Deprotonation from Metalation: Thia‐Fries Rearrangement

Angewandte Chemie (2008)

Alan M. Dyke D. Michael Gill Jeremy N. Harvey Alison J. Hester Guy C. Lloyd‐Jones

Aufgeklärt: Mithilfe von 2H-, 18O- und 34S-markierten Aryltriflaten ließ sich zeigen, dass die Lithiumdiisopropylamid-vermittelte Thia-Fries-Umlagerung über eine irreversible ortho-Deprotonierung verläuft (siehe Schema; DIPA=Diisopropylamin, LDA=Lithiumdiisopropylamid). Die ortho-Metallierung dagegen führt ausschließlich zur Bildung eines Benz-ins. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

10.1002/ange.200800750

Cite

Citations (14)