Guannan Cao

Human Connectome Project

10.1016/j.media.2024.103431

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Species -Shared and -Unique Gyral Peaks on Human and Macaque Brains

Songyao Zhang Tuo Zhang Guannan Cao Jingchao Zhou Zhibin He

Cortical folding is an important feature of primate brains that plays a crucial role in various cognitive and behavioral processes. Extensive research has revealed both similarities and differences in folding morphology and brain function among primates including macaque and human. The folding morphology is the basis of brain function, making cross-species studies on folding morphology are important for understanding brain function and species evolution. However, prior studies on cross-species folding morphology mainly focused on partial regions of the cortex instead of the entire brain. Previously, we defined a whole-brain landmark based on folding morphology: the gyral peak. It was found to exist stably across individuals and ages in both human and macaque brains. In this study, we identified shared and unique gyral peaks in human and macaque, and investigated the similarities and differences in the spatial distribution, anatomical morphology, and functional connectivity of them.

Morphology

Folding (DSP implementation)

Brain morphometry

Human brain

10.7554/elife.90182.1

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Reviewer #1 (Public Review): Species -Shared and -Unique Gyral Peaks on Human and Macaque Brains

Songyao Zhang Tuo Zhang Guannan Cao Jingchao Zhou Zhibin He

Cortical folding is an important feature of primate brains that plays a crucial role in various cognitive and behavioral processes. Extensive research has revealed both similarities and differences in folding morphology and brain function among primates including macaque and human. The folding morphology is the basis of brain function, making cross-species studies on folding morphology are important for understanding brain function and species evolution. However, prior studies on cross-species folding morphology mainly focused on partial regions of the cortex instead of the entire brain. Previously, we defined a whole-brain landmark based on folding morphology: the gyral peak. It was found to exist stably across individuals and ages in both human and macaque brains. In this study, we identified shared and unique gyral peaks in human and macaque, and investigated the similarities and differences in the spatial distribution, anatomical morphology, and functional connectivity of them.

Morphology

Folding (DSP implementation)

Brain morphometry

Human brain

10.7554/elife.90182.1.sa1

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Author Response: Species -Shared and -Unique Gyral Peaks on Human and Macaque Brains

Songyao Zhang Tuo Zhang Guannan Cao Jingchao Zhou Zhibin He

Cortical folding is an important feature of primate brains that plays a crucial role in various cognitive and behavioral processes. Extensive research has revealed both similarities and differences in folding morphology and brain function among primates including macaque and human. The folding morphology is the basis of brain function, making cross-species studies on folding morphology important for understanding brain function and species evolution. However, prior studies on cross-species folding morphology mainly focused on partial regions of the cortex instead of the entire brain. Previously, we defined a whole-brain landmark based on folding morphology: the gyral peak. It was found to exist stably across individuals and ages in both human and macaque brains. In this study, we identified shared and unique gyral peaks in human and macaque, and investigated the similarities and differences in the spatial distribution, anatomical morphology, and functional connectivity of them.

10.7554/elife.90182.2.sa2

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Author response: Species -shared and -unique gyral peaks on human and macaque brains

Songyao Zhang Tuo Zhang Guannan Cao Jingchao Zhou Zhibin He

10.7554/elife.90182.3.sa2

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Species -shared and -unique gyral peaks on human and macaque brains

eLife (2023)

Songyao Zhang Tuo Zhang Guannan Cao Jingchao Zhou Zhibin He

Cortical folding is an important feature of primate brains that plays a crucial role in various cognitive and behavioral processes. Extensive research has revealed both similarities and differences in folding morphology and brain function among primates including macaque and human. The folding morphology is the basis of brain function, making cross-species studies on folding morphology important for understanding brain function and species evolution. However, prior studies on cross-species folding morphology mainly focused on partial regions of the cortex instead of the entire brain. Previously, our research defined a whole-brain landmark based on folding morphology: the gyral peak. It was found to exist stably across individuals and ages in both human and macaque brains. Shared and unique gyral peaks in human and macaque are identified in this study, and their similarities and differences in spatial distribution, anatomical morphology, and functional connectivity were also dicussed.

10.7554/elife.90182

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Species -Shared and -Unique Gyral Peaks on Human and Macaque Brains

bioRxiv (Cold Spring Harbor Laboratory) (2023)

Songyao Zhang Tuo Zhang Guannan Cao Jingchao Zhou Zhibin He

Abstract Cortical folding is an important feature of primate brains that plays a crucial role in various cognitive and behavioral processes. Extensive research has revealed both similarities and differences in folding morphology and brain function among primates including macaque and human. The folding morphology is the basis of brain function, making cross-species studies on folding morphology important for understanding brain function and species evolution. However, prior studies on cross-species folding morphology mainly focused on partial regions of the cortex instead of the entire brain. Previously, we defined a whole-brain landmark based on folding morphology: the gyral peak. It was found to exist stably across individuals and ages in both human and macaque brains. In this study, we identified shared and unique gyral peaks in human and macaque, and investigated the similarities and differences in the spatial distribution, anatomical morphology, and functional connectivity of them.

10.1101/2023.07.26.550760

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Species -Shared and -Unique Gyral Peaks on Human and Macaque Brains

Songyao Zhang Tuo Zhang Guannan Cao Jingchao Zhou Zhibin He

Cortical folding is an important feature of primate brains that plays a crucial role in various cognitive and behavioral processes. Extensive research has revealed both similarities and differences in folding morphology and brain function among primates including macaque and human. The folding morphology is the basis of brain function, making cross-species studies on folding morphology important for understanding brain function and species evolution. However, prior studies on cross-species folding morphology mainly focused on partial regions of the cortex instead of the entire brain. Previously, we defined a whole-brain landmark based on folding morphology: the gyral peak. It was found to exist stably across individuals and ages in both human and macaque brains. In this study, we identified shared and unique gyral peaks in human and macaque, and investigated the similarities and differences in the spatial distribution, anatomical morphology, and functional connectivity of them.

10.7554/elife.90182.2

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Reviewer #2 (Public Review): Species -Shared and -Unique Gyral Peaks on Human and Macaque Brains

Songyao Zhang Tuo Zhang Guannan Cao Jingchao Zhou Zhibin He

Cortical folding is an important feature of primate brains that plays a crucial role in various cognitive and behavioral processes. Extensive research has revealed both similarities and differences in folding morphology and brain function among primates including macaque and human. The folding morphology is the basis of brain function, making cross-species studies on folding morphology are important for understanding brain function and species evolution. However, prior studies on cross-species folding morphology mainly focused on partial regions of the cortex instead of the entire brain. Previously, we defined a whole-brain landmark based on folding morphology: the gyral peak. It was found to exist stably across individuals and ages in both human and macaque brains. In this study, we identified shared and unique gyral peaks in human and macaque, and investigated the similarities and differences in the spatial distribution, anatomical morphology, and functional connectivity of them.

Morphology

Folding (DSP implementation)

Brain morphometry

Human brain

10.7554/elife.90182.1.sa0

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Brain functional gradients are related to cortical folding gradient

Cerebral Cortex (2024)

Zhibin He Tuo Zhang Qiyu Wang Songyao Zhang Guannan Cao

Abstract Cortical folding is closely linked to brain functions, with gyri acting more like local functional “hubs” to integrate information than sulci do. However, understanding how anatomical constraints relate to complex functions remains fragmented. One possible reason is that the relationship is estimated on brain mosaics divided by brain functions and cortical folding patterns. The boundaries of these hypothetical hard-segmented mosaics could be subject to the selection of functional/morphological features and as well as the thresholds. In contrast, functional gradient and folding gradient could provide a more feasible and unitless platform to mitigate the uncertainty introduced by boundary definition. Based on the MRI datasets, we used cortical surface curvature as the folding gradient and related it to the functional connectivity transition gradient. We found that, at the local scale, the functional gradient exhibits different function transition patterns between convex/concave cortices, with positive/negative curvatures, respectively. At the global scale, a cortex with more positive curvature could provide more function transition efficiency and play a more dominant role in more abstractive functional networks. These results reveal a novel relation between cortical morphology and brain functions, providing new clues to how anatomical constraint is related to the rise of an efficient brain function architecture.

Folding (DSP implementation)

10.1093/cercor/bhae453

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i-10 index

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