Meng Zheng

Beijing Jiaotong University

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Xu Lu

Nantong University

Chao Huang

Huazhong University of Science and Technology

Bingran Chen

Nantong University

Tao Zhu

Huazhong University of Science and Technology

Hui Zhao

Yangtze University

Ting Ye

Fudan University

Huijun Liu

University of South China

Ke‐Qiong Deng

Wuhan University

Xiangyi Wang

North China University of Science and Technology

Ying Ye

Children's Hospital of Fudan University

Cooperative Institutions

RELX Group (Netherlands)

Sichuan University

Chinese Academy of Sciences

Nantong University

Chinese Academy of Medical Sciences & Peking Union Medical College

Istituti di Ricovero e Cura a Carattere Scientifico

Wuhan University

Huazhong University of Science and Technology

University of Chinese Academy of Sciences

National Cancer Institute

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Immunization with a low dose of zymosan A confers resistance to depression-like behavior and neuroinflammatory responses in chronically stressed mice

Behavioural Pharmacology (2024)

Huijun Liu Tao Zhu Linlin Zhang Fu Li Meng Zheng

Stimulation of the innate immune system prior to stress exposure is a possible strategy to prevent depression under stressful conditions. Based on the innate immune system stimulating activities of zymosan A, we hypothesize that zymosan A may prevent the development of chronic stress-induced depression-like behavior. Our results showed that a single injection of zymosan A 1 day before stress exposure at a dose of 2 or 4 mg/kg, but not at a dose of 1 mg/kg, prevented the development of depression-like behaviors in mice treated with chronic social defeat stress (CSDS). The prophylactic effect of a single zymosan A injection (2 mg/kg) on CSDS-induced depression-like behaviors disappeared when the time interval between zymosan A and stress exposure was extended from 1 day or 5 days to 10 days, which was rescued by a second zymosan A injection 10 days after the first zymosan A injection and 4 days (4×, once daily) of zymosan A injections 10 days before stress exposure. Further analysis showed that a single zymosan A injection (2 mg/kg) 1 day before stress exposure could prevent the CSDS-induced increase in pro-inflammatory cytokines in the hippocampus and prefrontal cortex. Inhibition of the innate immune system by pretreatment with minocycline (40 mg/kg) abolished the preventive effect of zymosan A on CSDS-induced depression-like behaviors and CSDS-induced increase in pro-inflammatory cytokines in the brain. These results suggest that activation of the innate immune system triggered by zymosan A prevents the depression-like behaviors and neuroinflammatory responses in the brain induced by chronic stress.

Zymosan

Depression

Social defeat

10.1097/fbp.0000000000000774

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[A brief history of ancient Chinese dietotherapy].

PubMed (1985)

Meng Zheng

Source

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Research on LiDAR Multi-Target Tracking Method Based on BEV Perspective

2021 China Automation Congress (CAC) (2024)

Baigen Cai Meng Zheng Linguo Chai Xiao Xiao Wei Shangguan

Tracking (education)

10.1109/cac63892.2024.10865794

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Zymosan A produces a rapid and sustained antidepressant effect in chronically stressed mice by stimulating hippocampal microglia

Behavioural Pharmacology (2023)

Tao Zhu Bingran Chen Han Han Xu Lu Zhuo Chen

Recent studies had reported that compounds that stimulate microglia could be developed as potential drugs for the treatment of depression due to their reversal effect on depression-like behaviors in chronically stressed mice. Zymosan A is a cell wall preparation of Saccharomyces cerevisiae composed of β-glucans. Based on its immuno-stimulatory activities, we hypothesized that zymosan A might have a therapeutic effect on depression. Our results showed that a single injection of zymosan A 5 h before behavioral tests at a dose of 1 or 2 mg/kg, but not at a dose of 0.5 mg/kg, reversed chronic unpredictable stress (CUS)-induced depression-like behaviors in mice in the tail suspension test, forced swimming test, and sucrose preference test. Time-dependent analysis showed that the antidepressant effect of zymosan A (2 mg/kg) in CUS mice became statistically significant at 5 and 8 h, but not at 3 h, and persisted for at least 7 days. Fourteen days after a single injection of zymosan A, no antidepressant effect was observed anymore. However, the disappeared antidepressant effect of zymosan A was restored by a second zymosan A injection (2 mg/kg, 5 h) 14 days after the first zymosan A injection. Stimulation of microglia was essential for the antidepressant effect of zymosan A because pre-inhibition of microglia by minocycline or pre-depletion of microglia by PLX3397 prevented the antidepressant effect of zymosan A. Based on these effects of zymosan A, zymosan A administration could be developed as a new strategy for the treatment of depression.

Zymosan

Tail suspension test

10.1097/fbp.0000000000000738

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Preparation of Naringenin Nanosuspension and Its Antitussive and Expectorant Effects

Molecules (2022)

Zhengqi Dong Rui Wang Mingyue Wang Meng Zheng Xiaotong Wang

Naringenin (NRG) is a natural flavonoid compound abundantly present in citrus fruits and has the potential to treat respiratory disorders. However, the clinical therapeutic effect of NRG is limited by its low bioavailability due to poor solubility. To enhance the solubility, naringenin nanosuspensions (NRG-NSps) were prepared by applying tocopherol polyethylene glycol succinate (TPGS) as the nanocarrier via the media-milling method. The particle size, morphology, and drug-loading content of NRG-NSps were examined, and the stability was evaluated by detecting particle size changes in different physiological media. NRG-NSps exhibited a flaky appearance with a mean diameter of 216.9 nm, and the drug-loading content was 66.7%. NRG-NSps exhibited good storage stability and media stability. NRG-NSps presented a sustainable release profile, and the cumulative drug-release rate approached approximately 95% within 7 d. NRG-NSps improved the antitussive effect significantly compared with the original NRG, the cough frequency was decreased from 22 to 15 times, and the cough incubation period was prolonged from 85.3 to 121.6 s. Besides, NRG-NSps also enhanced expectorant effects significantly, and phenol red secretion was increased from 1.02 to 1.45 μg/mL. These results indicate that NRG-NSps could enhance the bioavailability of NRG significantly and possess a potential clinical application.

Expectorant

10.3390/molecules27030741

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Citations (19)

Contents

Gastrointestinal Endoscopy (2022)

J Leighton Andrew Brock Carol E. Semrad David J. Hass N Guda

10.1016/s0016-5107(22)01980-0

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Self-management of psoriasis vulgaris treatment burden: A Review

Medicine (2023)

Dan Zhu Na Li Xiang Yan Meng Zheng

Psoriasis vulgaris is complicated with metabolic syndrome and other diseases, which affects the longevity of patients. Its repeated attacks bring obvious and long-term treatment burden to patients, and improper self-management can aggravate disease symptoms and increase the risk of complications. To summarize the existing evidence on the self-management of psoriasis vulgaris treatment burden. Systematic search was performed in database. Two researchers reviewed, extracted, and summarized evidence from the literature. Nine studies were included, of which 3 guidelines, the number of fields with standardized scores in various domains ≥60% of the evaluation results of the 3 guidelines was at least 4, quality evaluation are all above Grade B, demonstrated higher quality of guidelines, 3 RCTs, 2 analytical studies, and 2 literature reviews. The evaluation results of these included literatures were of high quality. We summarized the data in 6 areas, including oral medication management, topical treatment management, risk factors, living habits, physical exercise, and biologics managements. Finally, we present 34 items of best evidence. This study provides the basis for the management of treatment burden of psoriasis vulgaris. According to this study, medical workers guide patient to reduce the disease and treatment burden.

Disease management

10.1097/md.0000000000035392

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Intranasal Monophosphoryl Lipid a Administration Ameliorates depression-like Behavior in Chronically Stressed Mice Through Stimulation of Microglia

Neurochemical Research (2023)

Meng Zheng Tao Zhu Bingran Chen Hui Zhao Xu Lu

Tail suspension test

Systemic administration

10.1007/s11064-023-03974-0

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Citations (5)