Ovidiu Simion Cotoi

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

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Diana Maria Chiorean

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Iuliu Gabriel Cocuz

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Horațiu Suciu

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Marius Harpa

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Dan Simionescu

Biocom

Silviu Horia Morariu

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Raluca Niculescu

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Melinda-Ildiko Mitranovici

Institutul de Cercetari Electrotehnice

Ionela Movileanu

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Andreea Cătălina Tinca

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

Cooperative Institutions

Universitatea de Medicină, Farmacie, Științe și Tehnologie „George Emil Palade” din Târgu Mureș

151

Spitalul Clinic Judetean Mures

Spitalul Clinic Judetean de Urgenta Târgu Mureş

Clinical Emergency Hospital Bucharest

Eindhoven University of Technology

Medizinische Hochschule Hannover

Aarhus University Hospital

University of California, Irvine

Clemson University

Bakulev Scientific Center for Cardiovascular Surgery Russian Academy of Medical Sciences

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Bioreactor conditioning of valve scaffolds seeded internally with adult stem cells

Tissue Engineering and Regenerative Medicine (2016)

Allison Kennamer Leslie Neil Sierad Richard Pascal Nicholas Rierson Christopher Albers

Decellularization

10.1007/s13770-016-9114-1

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VISTA, PDL-L1, and BRAF—A Review of New and Old Markers in the Prognosis of Melanoma

Medicina (2022)

Andreea Cătălina Tinca Iuliu Gabriel Cocuz Mihaela Cornelia Șincu Raluca Niculescu Adrian Horațiu Sabău

Melanoma is currently known as one of the most aggressive malignant tumors. The prognostic factors and particularities of this neoplasm are a persistent hot topic in the medical field. This review has multiple purposes. First, we aim to summarize the known data regarding the histological and immunohistochemical appearance of this versatile tumor and to look further into the analysis of several widely used prognostic markers, such as B-Raf proto-oncogene, serine/threonine kinase BRAF. The second purpose is to analyze the data on the new prognostic markers, V-domain Immunoglobulin Suppressor of T cell Activation (VISTA) and Programmed death-ligand 1 (PD-L1). VISTA is a novel target that is considered to be highly important in determining the invasive potential and treatment response of a melanoma, and there are currently only a limited number of studies describing its role. PD-L1 is a marker with whose importance has been revealed in multiple types of malignancies, but its exact role regarding melanoma remains under investigation. In conclusion, the gathered data highlights the importance of correlations between these markers toward providing patients with a better outcome.

10.3390/medicina58010074

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Completing the Puzzle: Determinants, Comorbidities and Complications for Different Lung Cancer Subtypes: A Pilot Study

Life (2024)

Corina Eugenia Budin Iuliu Gabriel Cocuz Adrian-Horațiu Sabău Raluca Niculescu Cristian Cazacu

Background: Lung cancer remains one of the leading causes of cancer-related mortality worldwide, with multiple independent risk factors contributing to its development. The objective of this study was represented by the impact of independent risk factors, such as smoking, anemia, cachexia or COPD (chronic obstructive pulmonary disease) for lung cancer development. Methods: We conducted a retrospective study, and we analyzed a database of 412 patients hospitalized between 1 February and 31 December 2023 in the Pulmonology Department of the Mureș County Clinical Hospital. Following the analysis of the inclusion and exclusion criteria, the final analyzed group included 115 patients. Results: From the study group, 88 patients were diagnosed with non-small cell lung cancer and 27 with small cell lung cancer. Of the non-small cell lung cancer patients, 50% had adenocarcinoma and 50% had squamous cell carcinoma. Chronic obstructive pulmonary disease and cardiovascular diseases predominate as concomitant pathologies, with 82 and 81 cases identified among the patients evaluated, respectively. The incidence of diabetes mellitus was n = 20 for the patients, followed by asthma and other neoplasms. The body mass index was also analyzed with an average of 24.6. Body mass index does not correlate with histological type. The mean hemoglobin value in the group of patients was 12.8, and this could not be correlated with the histopathological type. Conclusions: Chronic obstructive pulmonary disease and lung cancer may just be two different clinical presentations based on the same etiological factors, which also have a lot of overlapping pathophysiological mechanisms. Therefore, Chronic obstructive pulmonary disease represents an individual risk factor for developing lung cancer. Smoking, as well as anemia, cachexia or other comorbidities (COPD), are individual risk factors for lung cancer.

Pulmonology

Obstructive lung disease

10.3390/life14121611

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Ischemic preconditioning and inflammatory response syndrome after reperfusion injury: an experimental model in diabetic rats.

PubMed (2015)

Bianca Liana Grigorescu Anca Georgescu Adrian-Dan Cioc Raluca-Ștefania Fodor Ovidiu Simion Cotoi

Quantification of local ischemia and inflammatory response syndrome correlated with histological changes associated with ischemia-reperfusion injury (IRI) after revascularization techniques. We included 12 adult male Wistar rats, aged eight weeks that were randomly divided into two groups. The first group acted as the control and at the second group, we induced diabetes by intraperitoneal streptozotocin administration (60 mg/kg). After eight weeks, the rats were subject to ischemic preconditioning for 10 minutes at three regular intervals. Twenty-four hours post-preconditioning, both groups were subject to ischemia for 20 minutes, followed by 30 minutes of reperfusion. Oxygen extraction was higher in Group 1, the arterio-venous CO2 gradient was higher in the control group, but not significant. The lactate production was higher in Group 1. The second group had a higher Na+ and also a significant difference in K+ values. Receptor for Advanced Glycation End (RAGE) values were higher in the second group but with no significant difference (RAGE1=0.32 ng/mL versus RAGE2=0.40 ng/mL). The muscle samples from the control group displayed significant rhabdomyolysis, damage to the nucleus, while the preconditioned group showed almost normal morphological characteristics. The lungs and kidneys were most damaged in the control group, with damage expressed as thickened alveolar septa, neutrophil infiltrates, eosinophilic precipitates in the proximal convolute tubule. Ischemic preconditioning significantly attenuates the ischemic reperfusion injury.

Ischemic Preconditioning

Intraperitoneal injection

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Caspase 3 expression and plasma level of Fas ligand as apoptosis biomarkers in inflammatory endotoxemic lung injury.

PubMed (2016)

Raluca Fodor Anca Georgescu Bianca Liana Grigorescu Adrian Cioc Mihály Veres

The objective of this study is to evaluate if the immunohistochemical expression of a pulmonary apoptosis marker and plasma level of Fas ligand (FasL) correlates with the dose- and time-dependent severity of lung injury, induced by the administration of lipo-polysaccharide (LPS) in an endotoxemic rat model.Our study included 30 male Wistar rats, randomly divided into three groups: one control group (n=6) and two experimental groups (n=12÷group), in whom we induced endotoxemia by intraperitoneal injection of progressively increasing doses of LPS (5, 10 mg÷kg). We measured FasL plasma levels of the rats at different time points and analyzed the relationships with markers of lung injury. To investigate the level of caspase 3-protein expression, the immunohistochemistry of the lung tissue was assessed.The median percentage of caspase 3-stained cells for the 5 mg÷kg LPS dose was 0.36%, for the 10 mg÷kg LPS dose was 0.4% and for the control group was 0.03% (p<0.0001). The elevated expression levels of caspase 3 were consistent with the altered lung morphologies observed (rs=0.88). LPS administration in rats resulted in a significant dose-dependent increase in the levels of plasma FasL (p<0.0001). These levels correlated with markers of lung injury: degree of hypoxemia (rs=-0.42), histological measured lung injury score (rs=0.72), the density of the caspase 3 staining cells in the immunohistochemistry assessment of apoptosis (rs=0.81) and with the plasma RAGE (receptor for advanced glycated end-products) values (rs=0.70).Apoptosis is increased in edotoxemia induced lung injury and is likely to contribute to alveolar injury.

Fas ligand

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Plasma procalcitonin is associated with all-cause and cancer mortality in apparently healthy men: a prospective population-based study

BMC Medicine (2013)

Ovidiu Simion Cotoi Jonas Manjer Bo Hedblad Gunnar Engström Olle Melander

Abstract Background The inflammatory mediator procalcitonin (PCT) has previously been associated with prognosis in myocardial infarction, cancer and sepsis patients. The importance of PCT in the general population is currently unknown. Our aim was to assess the relationship between plasma PCT and the risk of all-cause and cause-specific mortality in apparently healthy individuals with no previous history of cardiovascular disease or cancer. Methods We performed a prospective, population-based study on 3,322 individuals recruited from the Malmö Diet and Cancer cohort, with a median follow-up time of 16.2 years. Plasma PCT, high-sensitivity C-reactive protein (hsCRP), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides and cystatin C were measured at baseline and a thorough risk factor assessment was performed for all subjects. The primary end-points of the study were all-cause mortality, cancer mortality and cardiovascular mortality. Results Men had higher PCT levels compared to women. In Cox proportional hazard models adjusted for age, sex, hypertension, diabetes, plasma lipids, renal function, body mass index and smoking, baseline PCT was associated with all-cause mortality and cancer mortality in men. The hazard ratio (HR) for men with PCT levels within the highest compared with the lowest quartile was 1.52 (95% confidence interval (CI) 1.07 to 2.16; P = 0.024) for all-cause mortality and 2.37 (95% CI 1.36 to 4.14; P = 0.006) for cancer mortality. Additionally, men with increased plasma PCT were found to be at a higher risk to develop colon cancer (HR per 1 SD increase = 1.49 (95% CI 1.13 to 1.95); P = 0.005). In multivariate Cox regression analyses with mutual adjustments for PCT and hsCRP, PCT was independently associated with cancer death (HR per 1 SD increase = 1.28 (95% CI 1.10 to 1.49); P = 0.001) and hsCRP with cardiovascular death (HR per 1 SD increase = 1.42 (95% CI 1.11 to 1.83); P = 0.006) in men. We found no significant correlations between baseline PCT or hsCRP and incident cancer or cardiovascular death in women. Conclusions We disclose for the first time important independent associations between PCT and the risk for all-cause and cancer mortality in apparently healthy men. Our findings warrant further investigation into the mechanisms underlying the relationship between PCT and cancer.

Procalcitonin

10.1186/1741-7015-11-180

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Săpăturile arheologice de la Iţcani - Ferma 2 (1998-1999)

Ovidiu Simion Cotoi Mircea Ignat Ion Mareș Bogdan Niculică Constantin Ursu

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Actualities in the Morphology and Immunohistochemistry of Cutaneous and Ocular Melanoma: What Lies Ahead? A Single-Centre Study

Biomedicines (2022)

Andreea Cătălina Tinca Raluca Moraru Iuliu Gabriel Cocuz Mihaela Cornelia Șincu Raluca Niculescu

Melanoma is the most aggressive melanocytic tumor whose incidence is continuously increasing worldwide.We highlight the morphological, immunohistochemistry, and particularities of various melanoma types based on the cases diagnosed in our department from 2017 to 2021.We present 100 melanoma cases and one capsular nevus case. The most common type was nodular melanoma. The immunohistochemistry markers used were SRY-box transcription factor 10 (SOX10), S100 protein, human melanoma black 45 (HMB45), and melanoma antigen recognized by T cells 1 (Melan-A). Uveal melanoma and conjunctival melanoma represent particular tumors with independent prognostic factors. Uveal melanoma requires assessment of macrophages, microvascularisation, and mitoses. Sentinel lymph node metastases are essential targets that provide staging tools. Conjunctival melanoma and capsular nevi are diagnostic pitfalls.Melanoma can appear in various forms, and sometimes the diagnosis might be unclear. Today, immunohistochemistry remains the most important tool in confirming the diagnosis and prognosis for this type of neoplasia.

HMB-45

10.3390/biomedicines10102500

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Relapsing Polychondritis Possibly Caused by Chronic Infection with Borrelia Burgdorferi – Case Report

Acta Medica Marisiensis (2015)

Silviu Horia Morariu M.A. Badea Ovidiu Simion Cotoi Mihai Dorin Vartolomei Iudita-Maria Badea

Abstract Introduction: Relapsing polychondritis has been described by Rudolph von Jaksch Warthenhorst in 1923 under the name of polichondropathy. Although the etiology is unknown, an autoimmune mechanism is likely due to formation of autoantibodies to type II collagen in the extracellular matrix of the cartilage with its consequent destruction. Case report: We present a case with relapsing polychondritis according to McAdam and Damiani criteria and with positive Western blot reaction for Ac IgG anti Borrelia burgdorferi. Serological reaction became negative and the patient presented favorable evolution at 6 months follow-up after corticosteroid therapy and antibiotics. Conclusion: Chronic infection with Borrelia burgdorferi may play a role in relapsing polychondritis determinism

Etiology

10.1515/amma-2015-0018

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Time- and dose-dependent severity of lung injury in a rat model of sepsis.

PubMed (2015)

Raluca-Ștefania Fodor Anca Georgescu Adrian-Dan Cioc Bianca Liana Grigorescu Ovidiu Simion Cotoi

Different animal models of experimental lung injury have been used to investigate mechanisms of lung injury. Lipopolysaccharide (LPS) administration is the most often used approach to model the consequences of bacterial sepsis. We created an endotoxemia rat model, simulating sepsis-related lung injury, in order to quantify the time and dose dependent severity lesions induced by the administration of lipopolysaccharide. Our study included 42 male Wistar rats, randomly divided into four groups: one control group (n=6) and three experimental groups (n=12/group) in whom we induced sepsis by intraperitoneal injection of progressively increasing doses of LPS (3, 5, 10 mg/kg). At six hours, the animals included in the groups with higher doses of LPS developed thrombocytopenia, elevated lactate levels, and liver and renal injury in a dose and time dependent manner. The severity of hypoxemia at six hours correlated with the increasing doses of LPS, with a slight improvement at 24 hours. Lung injury scores became more severe with increased dose and time of exposure to LPS without reaching the level of hyaline membranes formation. We also demonstrated translocation of a protein from the airspaces into plasma (RAGE - receptor for advanced glycation end products). Induction of sepsis using LPS is a known experimental model, but LPS treatment in rats does not cause the severe endothelial and epithelial injury that occurs in humans with acute respiratory distress syndrome (ARDS). In our study, the clinical, laboratory and histopathological findings confirmed sepsis and the damage of the alveolar-capillary membrane in a dose-dependent manner.

Diffuse alveolar damage

Hyaline

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