The surface of the skin consists of a layer of dead, keratinised epithelial cells. It is not flat but forms a pattern of ridges and grooves. The best known of these are the fingerprints or dermatoglyphs, but even at sites where such patterns are absent the surface is not smooth but covered by a more-or-less regular pattern of intersecting grooves. The intersecting grooves form nearly regular geometrical figures (Tring and Murgatroyd, 1974) and the variations of these with site, age and disease have been described (Pinkus, 1927; Chin and Dobson, 1964; Verbov, 1975; Wagner and Goltz, 1979).

Texture (cosmology)

Flat surface

10.1007/978-1-349-06077-1_44

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A new micronized 5-methoxypsoralen preparation. Higher bioavailability and lower UVA dose requirement.

Acta Dermato Venereologica (1992)

P. Treffel S. Makki P Humbert H Khaldoun P Agache

A new tablet of micronized 5-methoxypsoralen (5-MOP) and a commonly used tablet in therapy (Psoraderm 5) were compared in 12 healthy subjects. Each subject ingested 1.2 mg/kg body weight of each formulation on different days. Bioavailability and phototoxicity of 5-MOP were compared. The results showed that serum and suction blister concentrations were significantly higher and occurred earlier after the oral intake of the micronized preparation. A series of graduated UVA doses were administered, one dose each time the concentration serum peaked, in order to determine the minimum phototoxic dose for each formulation. The micronized preparation induced greater photosensitivity than the unmicronized one. The micronized 5-MOP tablet may thus allow lower doses of UVA to achieve therapeutic results in photochemotherapy and a shortened waiting period following ingestion of drug.

Phototoxicity

10.2340/00015555726567

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Citations (9)

Use of a surface recovery technique to evaluate percutaneous absorption of 5-methoxypsoralen in humans

Archives of Dermatological Research (1991)

P. Treffel P Humbert S. Makki B. Faivre P Agache

Methoxsalen

10.1007/bf00371791

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Citations (6)

Percutaneous absorption of three psoralens commonly used in therapy: Effect of skin occlusion (in vitro study)