Marzieh Dehghani

Tarbiat Modares University

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Mohammad Saadatnia

Isfahan University of Medical Sciences

Rokhsareh Meamar

Isfahan University of Medical Sciences

Behnam Hajipour‐Verdom

Tarbiat Modares University

Parinaz Ghadam

Alzahra University

Leila Dehghani

Shahid Beheshti University of Medical Sciences

Parviz Abdolmaleki

Tarbiat Modares University

Maedeh Talebi

Islamic Azad University, Lahijan Branch

Hamidreza Nikyar

Islamic Azad University of Najafabad

Behnaz Ansari

Isfahan University of Medical Sciences

Marzieh Ghasemi

Isfahan University of Medical Sciences

Cooperative Institutions

Isfahan University of Medical Sciences

Alzahra Medical and Education Center

University of Isfahan

Tarbiat Modares University

Tehran University of Medical Sciences

Islamic Azad University of Najafabad

Islamic Azad University, Isfahan

Alzahra University

Shahid Beheshti University of Medical Sciences

Tabriz University of Medical Sciences

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The role of endothelial progenitor cells in transient ischemic attack patients for future cerebrovascular events

Journal of Research in Medical Sciences (2016)

Rokhsareh Meamar Hamidreza Nikyar Leila Dehghani Maedeh Talebi Marzieh Dehghani

Background: The role of endothelial progenitor cells (EPCs) in the maintenance of vascularization following ischemic brain after experimental stroke has been established. Accordingly, in this study, we evaluated the role of circulating EPCs in transient ischemic attack (TIA) patients for future cerebrovascular (CV) events. Materials and Methods: The level of circulating EPCs (staining markers: CD34, CD309) were determined using flow cytometry at 24 h after TIA in thirty consecutive patients. The EPCs level was also evaluated once in thirty healthy volunteers. Over a period of 12 months, all patients were evaluated by an experienced neurologist for recurrent TIA, stroke or death induced by CV disorders. Results: Circulating EPCs increased in patients group following the first attack of TIA when compared with controls. By analysis of covariance, cardiovascular event history, hyperlipidemia, and statin therapy remained significant independent predictors of EPCs. The mean (standard deviation) duration of follow-up was 10.5 (3.1) months (range, 2–12 months). During follow-up, a total of three patients died due to CV accident and four patients experienced again recurrent TIA. By analyzing data with Cox regression, EPC did not predict the future CV events in TIA patients. Conclusion: Increased incidence of future CV events did not occur in those patients with elevated EPCs in the first attack of TIA. The significant predicting factors of EPCs were cardiovascular event history, hyperlipidemia, and statin therapy.

Hyperlipidemia

Stroke

10.4103/1735-1995.183995

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Green Synthesis of ZnO-NPs by Juglans regia Green Husk Aqueous Extract

Marzieh Dehghani Parinaz Ghadam

Nanobiotechnology is a broad science that provides nanomaterials to solve many medical, agricultural, engineering, biological, and chemical problems. Nanoparticles (NPs) are nanomaterials with zero dimensions. Due to its numerous applications in a variety of scientific fields, semiconductor NPs synthesis has received a lot of attention in recent times. There are three methods that can be used to make NPs including chemical, biological, and physical methods. ZnO-NPs has been synthesized by the biological method in this study. The green husk of Juglans regia aqueous extract was used to make NPs using the biological method. Transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and UV-Visible spectroscopy were used to examine the NPs' properties. The biosynthesized ZnO-NPs have a strong SPR band at 360 nm, as demonstrated by the UV-Vis analysis results. These NPs are crystalline. In addition, the results of the DLS analysis showed that the hydrodynamic diameter of 90% of the biosynthesized zinc oxide is less than 292.55 nm. Furthermore, the TEM analysis confirmed that these NPs have spherical and ellipsoidal shapes.

Nanomaterials

Nanobiotechnology

10.3390/iocn2023-14444

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Effect of precipitating agent, N2 gas, extract volume and pH on the magnetic properties of magnetite nanoparticles by green synthesis from aqueous pomegranate peel extract

Frontiers in Chemistry (2024)

Marzieh Dehghani Behnam Hajipour‐Verdom Parviz Abdolmaleki

Superparamagnetic nanoparticles (SPMNPs) have attracted considerable attention in biomedicine, particularly magnetic hyperthermia for cancer treatment. However, the development of efficient and eco-friendly methods for synthesizing SPMNPs remains a challenge. This study reports on a green synthesis approach for SPMNPs using pomegranate peel extract as a stabilizing agent. The effects of various synthesis parameters, including the type of precipitating agent (NH 3 and NaOH), N 2 gas, extract volume, and pH, were systematically investigated with regard to the size, morphology, and magnetic properties of the nanoparticles. The results showed that reducing the volume of the extract increased the saturation magnetization of the nanoparticles. N 2 gas was found to be essential in preventing the oxidation of the nanoparticles. The type of precipitating agent also affected the size and magnetization of the nanoparticles, with NaOH leading to the synthesis of SPMNPs with higher magnetization (∼4 times) compared to NH 3 . Additionally, nanoparticles synthesized at pH 10 exhibited higher magnetization than those synthesized at pH 8 and 12. In conclusion, the optimized synthesis conditions significantly affected the magnetization and stability of SPMNPs. These nanoparticles are suitable for use in magnetic nanofluid hyperthermia applications.

Superparamagnetism

Ferrofluid

10.3389/fchem.2024.1413077

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