Amin Shavandi

Université Libre de Bruxelles

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Co-Authors

Lei Nie

Xinyang Normal University

100

Oseweuba Valentine Okoro

Université Libre de Bruxelles

Guohua Jiang

Zhejiang Sci-Tech University

Alaa El‐Din A. Bekhit

University of Otago

Yanfang Sun

Zhejiang Sci-Tech University

Hafez Jafari

Université Libre de Bruxelles

Daria Podstawczyk

Wrocław University of Science and Technology

Houman Alimoradi

Université Libre de Bruxelles

Khaydar E. Yunusov

Academy of Sciences Republic of Uzbekistan

Masoud Hamidi

Guilan University of Medical Sciences

Cooperative Institutions

Institute for Health Metrics and Evaluation

2,085

University of Washington

1,982

Tehran University of Medical Sciences

427

University of Sydney

331

University of Electronic Science and Technology of China

299

Institute for Musculoskeletal Health

230

University College London

227

Veterans Health Administration

193

Royal North Shore Hospital

165

National Health and Medical Research Council

145

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Vaginal Administration of Contraceptives

Scientia Pharmaceutica (2020)

Esmat Jalalvandi Hafez Jafari Christiani A. Amorim Denise Freitas Siqueira Petri Lei Nie

While contraceptive drugs have enabled many people to decide when they want to have a baby, more than 100 million unintended pregnancies each year in the world may indicate the contraceptive requirement of many people has not been well addressed yet. The vagina is a well-established and practical route for the delivery of various pharmacological molecules, including contraceptives. This review aims to present an overview of different contraceptive methods focusing on the vaginal route of delivery for contraceptives, including current developments, discussing the potentials and limitations of the modern methods, designs, and how well each method performs for delivering the contraceptives and preventing pregnancy.

Unintended Pregnancy

10.3390/scipharm89010003

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Citations (11)

Corrigendum to “Regenerated silk fibroin and alginate composite hydrogel dressings loaded with curcumin nanoparticles for bacterial-infected wound closure” [Biomater. Adv. 149 (2023) 213405]

Biomaterials Advances (2025)

Yanting Jing Li-Ming Ruan Guohua Jiang Lei Nie Amin Shavandi

Fibroin

10.1016/j.bioadv.2025.214224

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Citations (0)

Kinetic modelling of the solid–liquid extraction process of polyphenolic compounds from apple pomace: influence of solvent composition and temperature

Bioresources and Bioprocessing (2021)

Parinaz Hobbi Oseweuba Valentine Okoro Christine Delporte Houman Alimoradi Daria Podstawczyk

Abstract This study aims to assess kinetic modelling of the solid–liquid extraction process of total polyphenolic compounds (TPC) from apple pomace (AP). In this regard, we investigated the effects of temperature and solvent (i.e. water, ethanol, and acetone) on TPC extraction over various periods. The highest TPC yield of 11.1 ± 0.49 mg gallic acid equivalent (GAE)/g db (dry basis) was achieved with a mixture of 65% acetone–35% water (v/v) at 60 °C. The kinetics of the solvent-based TPC extraction processes were assessed via first-order and second-order kinetic models, with an associated investigation of the kinetic parameters and rate constants, saturation concentrations, and activation energies. The second-order kinetic model was sufficient to describe the extraction mechanism of TPC from AP. This study provides an understanding of the mass transfer mechanism involved in the polyphenolic compound extraction process, thus facilitating future large-scale design, optimization, and process control to valorize pomace waste. Graphical Abstract

Pomace

10.1186/s40643-021-00465-4

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Citations (50)

Rizatriptan benzoate-loaded dissolving microneedle patch for management of acute migraine therapy

Journal of Biomaterials Applications (2024)

Chao Zhong Xiufeng Zhang Yanfang Sun Zhong Shen Yanan Mao

In this study, dissolving microneedles (MNs) using polyvinyl alcohol (PVA) and poly (1-vinylpyrrolidone-co-vinyl acetate) (P(VP-co-VA)) as matrix materials were developed for transdermal delivery of rizatriptan benzoate (RB) for acute migraine treatment. In-vitro permeation studies were conducted to assess the feasibility of the as-fabricated dissolving MNs to release RB. Drug skin penetration were tested by Franz diffusion cells, showing an increase of the transdermal flux compared to passive diffusion due to the as-fabricated dissolving MNs having a sufficient mechanical strength to penetrate the skin and form microchannels. The pharmacological study in vivo showed that RB-loaded dissolving MNs significantly alleviated migraine-related response by up-regulating the level of 5-hydroxytryptamine (5-HT) and down-regulating the levels of calcitonin gene-related peptide (CGRP) and substance P (SP). In conclusion, the RB-loaded dissolving MNs have advantages of safety, convenience, and high efficacy over conventional administrations, laying a foundation for the transdermal drug delivery system treatment for acute migraine.

Rizatriptan

10.1177/08853282241237323

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Citations (5)

Thermochemical Liquefaction of Pomace Using Sub/Supercritical Ethanol: an Integrated Experimental and Preliminary Economic Feasibility Study

BioEnergy Research (2022)

Oseweuba Valentine Okoro Lei Nie Jehan Waeytens Masoud Hamidi Amin Shavandi

Molar ratio

Pomace

10.1007/s12155-022-10511-4

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Citations (3)

Solar-powered and antibacterial water purification via Cu-BTC-embedded reduced graphene oxide nanocomposite aerogels

Chemical Engineering Journal (2023)

Ahmad Allahbakhsh Zeinab Jarrahi Gholamali Farzi Amin Shavandi

Specific surface area

10.1016/j.cej.2023.143472

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Citations (20)

Magnetic Force Microscopy and Nanoindentation on 3D Printed Magnetic Scaffolds for Neuronal Cell Growth

ACS Applied Polymer Materials (2023)

Alex Carvalho Alavarse Rafael Leonardo Cruz Gomes da Silva Pejman Ghaffari Bohlouli D.R. Cornejo Henning Ulrich

This study investigated the physicochemical properties of 3D printed sodium alginate (SA)/poly(vinyl alcohol) (PVA)-magnetic nanoparticle (MNP) hydrogels that were subsequently cross-linked using Ca2+ ions via postspraying. The rheological properties of the precursor hydrogels were assessed because they play a crucial role in printability. The SA/PVA composition of 12/8 wt %, both in the absence and presence of MNPs at concentrations of 1.0 mg/mL, 2.5 mg/mL, or 5.0 mg/mL, displayed good printability. Magnetic force microscopy (MFM) evidenced the random distribution of MNPs on the hydrogel surface and the aggregation of magnetic clusters with increasing MNP content. Nanoindentation tests using a silica colloidal probe allowed estimating the elastic modulus values of swollen 3D printed scaffolds. These values ranged from 1.0 MPa (SA12/PVA8) to 7.2 MPa (SA/PVA-MNP5). Confocal microscopy confirmed the presence of cells within the interior of the 3D printed scaffolds. The cytocompatibility or cytotoxicity assays showed that all 3D printed scaffolds were cytocompatible with HT-22 cells.

Vinyl alcohol

10.1021/acsapm.3c02565

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Citations (1)

Green recovery of polyphenolic compounds from food industry apple waste using subcritical water

Parinaz Hobbi Oseweuba Valentine Okoro Paul Musonge Lei Nie Amin Shavandi

Subcritical water extraction (SWE) technology, as an environmentally sustainable technique, was applied to optimize the recovery of polyphenolic compounds from apple pomace (AP). Box–Behnken experimental design approach was used to investigate the effects of four process variables; extraction temperature (100-220 ºC), extraction time (30-120 min), mean sample particle size (500-1000 µm) and solid to solvent ratio (1-10 g/100 mL) on total polyphenolic compounds (TPC) yield. The SWE conditions for the optimal TPC of 39.08 ± 1.10 mg GAE per g of AP on dry basis (db) were determined to be temperature of 203.71 ºC, time of 75 min, solid to solvent ratio of 1 g/100 mL and a mean sample particle size of 500 µm. The temperature and solid to solvent ratio were determined as the most statistically significant process variables that influenced TPC yield. At the optimum conditions, antioxidant activity (% DPPH inhibition activity) of the polyphenolic extract was found in the range of 15.38–92.90% as compared to ascorbic acid (8.64–95.90%). The findings of this study proposed that SWE as a green and efficient technology provided significant advantage in term of polyphenolic compounds yield, and AP could be utilized as potential raw material for SWE of valuable antioxidant polyphenolic compounds.

Pomace

Box–Behnken design

10.26434/chemrxiv-2022-0drh9

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Citations (3)

Inter-penetrating Polymer Network (IPN) for Drug Delivery

Apple Academic Press eBooks (2025)

Lei Nie Peng Ding Ling Wang Yaling Deng Oseweuba Valentine Okoro

10.1201/9781003592365-11

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Citations (0)

Fabrication and In Vitro Characterization of Polycaprolactone/Graphene Oxide/Collagen Nanofibers for Myocardial Repair

Macromolecular Materials and Engineering (2023)

Sema Seren Karapehlivan Mehmet Necati Danisik Zekiye Akdag Elif Nur Yildiz Oseweuba Valentine Okoro

Abstract This study is focused on fabricating tissue‐engineered electrospun nanofibers that contain polycaprolactone (PCL), graphene oxide (GO), and collagen (COL) to get an alternative treatment for cardiac injuries. GO (1.5 wt%) is used to support the contraction‐elongation of cardiomyocytes by improving electrical stimulation. The COL (1, 3, and 5 wt%) is the main component of the myocardial extracellular matrix have led to their frequent use in cardiac tissue engineering (CTE). The scanning electron microscope (SEM) images show the homogeneous and bead‐free morphologies of the nanofibers. Adding a high amount (3% and 5%) of COL decreases the tensile strength value of 17% PCL/1.5% GO nanofiber. 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) assay demonstrates that the COL addition increases cell viability compared to that in 17% PCL/1.5% GO nanofibers on the third day. The response of the nanofibers to alternating current (AC) signal is studied between the frequencies 40 and 10 5 Hz. The direct current (DC) conductivity values of the films are determined to be between 1.10 −10 and 6.10 −10 S m −1 at 25 °C. The AC conductivity values show frequency‐dependent behavior. Among the PCL/GO‐based electrospun nanofibers, 17% PCL/1.5% GO/5% COL nanofiber shows greater DC and AC conductivity than 17% PCL/1.5% GO nanofiber.

Polycaprolactone

Electrospinning

10.1002/mame.202300189

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Citations (4)