Avanish Kumar Srivastava

Advanced Materials and Processes Research Institute

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Neha Bisht

Chonnam National University Hospital

Chetna Dhand

Academy of Scientific and Innovative Research

Neeraj Dwivedi

Academy of Scientific and Innovative Research

Ludovic F. Dumée

Khalifa University of Science and Technology

Ajit Khosla

Xidian University

Shubham Jaiswal

Advanced Materials and Processes Research Institute

Hafsa Siddiqui

Advanced Materials and Processes Research Institute

Palash Naidu

Rani Durgavati University

Jeet Vishwakarma

Academy of Scientific and Innovative Research

Shaily Gupta

Vellore Institute of Technology University

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Advanced Materials and Processes Research Institute

Academy of Scientific and Innovative Research

Council of Scientific and Industrial Research

Bhopal Memorial Hospital & Research Centre

National University of Singapore

Indian Institute of Management Lucknow

IFTM University

University of Toronto

National Taiwan University

Khalifa University of Science and Technology

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Review—Recent Advances in Polydopamine-based Electrochemical Biosensors

Journal of The Electrochemical Society (2022)

Neha Bisht Neeraj Dwivedi Ajit Khosla Dibyendu Mondal Avanish Kumar Srivastava

The biosensor is a rapidly expanding field of science owing to its wide variety of applications in healthcare, pharmacology, environmental control, food quality assessment, security and defense, and, most notably, diagnostics. Among biosensors, electrochemical biosensors are immensely popular because of their high sensitivity, low detection limit, automation capabilities, low testing cost, and the emergence of electrochemical disposable devices capable of dealing with extremely small sample volumes. Biomolecule immobilization is a crucial step in biosensor development that necessitates the functionalization of the transducer surface. In 2007, polydopamine (PDA) is introduced as a substrate-independent coating material rich in catechol, imine, and amine groups, which provides a perfect environment for dense biomolecule immobilization on the transducer surface. PDA brings the world of possibilities for attaching biomolecules, changing their bio-catalytic capabilities, transferring electrons rapidly, and offering a rapid interface to provide a range of electrochemical signals to design unique diagnostic tools. This review attempts to assemble existing research progressed on PDA-based electrochemical biosensors in terms of enzymatic biosensors (based on H 2 O 2 , glucose, alcohol, and laccase), genosensors (DNA sensing), immunosensors, and aptasensors. Further, literature on the detection of thrombin, tumour markers, amino acids, and other therapeutically significant analytes has been collated to provide a comprehensive assessment of PDA-based biosensors. Furthermore, the future potential of PDA-based biosensors for the construction of smart sensor systems leveraging artificial intelligence and Internet of things technologies was discussed in this article.

Biomolecule

10.1149/1945-7111/ac9b95

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Citations (14)

Emerging electrochemical additive manufacturing technology for advanced materials: Structures and applications

Materials Today (2023)

Hafsa Siddiqui Netrapal Singh Palash Naidu Koyalada Bhavani Srinivas Rao Shaily Gupta

Electrochemical energy storage

10.1016/j.mattod.2023.10.008

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Synergizing chemistry: unveiling the potential of hybrid fillers for enhanced performance in shape memory polymers