Xiao Feng

Shanghai Institute of Technology

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Qingwei Meng

Chinese Academy of Medical Sciences & Peking Union Medical College

Liling Long

First Affiliated Hospital of GuangXi Medical University

Xuehui Wang

Chinese Academy of Sciences

Zonglin Jiao

ShenZhen People’s Hospital

Jun Zhang

Kunming Medical University

Bin‐Feng Cheng

Xinxiang Medical University

Tingting Ren

Collaborative Innovation Center of Chemistry for Energy Materials

Jingli Fan

Institute of Endemic Disease Control in Shandong Province

Hai-Jie Yang

Xinxiang Medical University

Shao-Qin Jian

Hainan Medical University

Cooperative Institutions

Wenzhou Medical University

Harbin Medical University

Third Affiliated Hospital of Harbin Medical University

First Affiliated Hospital of Wenzhou Medical University

Guangxi Medical University

Peking University

First Affiliated Hospital of GuangXi Medical University

Xinxiang Medical University

Shanghai Institute of Technology

Soochow University

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Thermal Oxidation Characteristics and Kinetics of Micron Aluminum Powder in Different Ambient Oxygen Concentration

Xiaoliang Zhang Ronghan Guo Xiao Feng Jiawei Fang Jiaqiang Xu

To study the effect of ambient atmosphere on the oxidation reaction of micron-grade aluminum powder, the oxidation process of atmospheres with oxygen concentrations of 7%, 11%, 15%, 21%, and 30% reacted with samples was investigated by simultaneous thermal analyzer. The results indicate that the oxidation process of samples exhibits a double-step mass gain law. Using mathematical modeling methods to analyze the thermal effect of simultaneous endothermic and exothermic reactions in the aluminum oxygen reaction process. The model-free kinetic methods were used to calculate the kinetics parameters of aluminum powder. As the oxygen concentration decreases, the ignition temperature of the samples increases, the thickness of the layer of the oxidation product decreases, and the average apparent activation energy of the aluminum powder rises to 350kJ·mol-1. The minimum ambient oxygen concentration for the oxidation of micron-grade aluminum powder is predicted to be approximately below 3.7%.

Thermal oxidation

10.2139/ssrn.4725766

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Distant Metastasis and Survival Outcomes after Computed Tomography-Guided Needle Biopsy in Resected Stage I-III Non-Small Cell Lung Cancer

Journal of Cancer (2017)

Yuhui Xi Jingli Fan Dehai Che Keke Zhai Tingting Ren

Background and objective Several reports describe the needle-tract implantation after percutaneous needle lung biopsy. The present study evaluated whether preoperative computed tomography-guided needle biopsy (CTNB) affected the distant metastasis and overall survival in patients with early non-small cell lung cancer (NSCLC). Methods A total of 1667 patients with pathological stage I-III NSCLC were assimilated. Of these, 168 patients received preoperative CTNB, whereas 1499 patients were not subjected to any biopsy before surgical resection. Propensity score matching method was adopted to balance the observed covariates between the two groups. Cox regression analysis and Kaplan-Meier estimations were used for survival analysis. Subset analysis was performed in the p-stage ≤ II cases. Results The distant metastasis and mortality were not significantly increased for all patients with preoperative CTNB (P = 0.142 and P = 0.125, respectively). The subset analysis of p-stage ≤ II cases showed that CTNB increased the risk of distant metastasis (P = 0.032) while not increasing the risk of mortality (P = 0.086). Conclusion CTNB can increase the risk of distant metastasis in the p-stage ≤ II patients.

Distant metastasis

T-stage

10.7150/jca.20784

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Citations (7)

Pectolinarin inhibited LPS-stimulated inflammation in microglial BV2 cells via NF-κB signaling pathway

Traditional Medicine Research (2024)

Bin‐Feng Cheng Xiao Feng Yuqian Dong Shao-Qin Jian Hao-Heng Yu

10.53388/tmr20230816002

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ESE1/AGR2 axis antagonizes TGF‐β‐induced epithelial‐mesenchymal transition in low‐grade pancreatic cancer

Cancer Medicine (2022)

Huijing Xu Jing Bai Ye Tian Xiao Feng Aiping Chen

Epithelium-specific ETS transcription factor 1 (ESE1) has been implicated in epithelial homeostasis, inflammation, as well as tumorigenesis, and cancer progression. However, numerous studies have reported contradictory roles-as an oncogene or a tumor suppressor of ESE1 in different cancers, and its function in the development and progression of pancreatic ductal adenocarcinoma (PDAC) has remained largely unexplored. Herein, we report that ESE1 was found upregulated in primary PDAC compared to normal pancreatic tissue, but high expression of ESE1 correlated to better relapse-free survival in patients with PDAC. Interestingly, ESE1 was found to exhibit dual roles in regulation of malignant properties of PDAC cells in that its overexpression promoted cell proliferation, whereas its downregulation enhanced epithelial-mesenchymal transition (EMT) phenotype. In the context of TGF-β-induced EMT, ESE1 is markedly downregulated at post-transcriptional level, and reconstituted ESE1 expression partially reversed TGF-β-induced EMT marker expression. Furthermore, we identify AGR2 as a novel transcriptional target of ESE1 that participates in TGF-β-induced EMT in PDAC. Collectively, our findings reveal an ESE1/AGR2 axis that interacts with TGF-β signaling to modulate EMT phenotype in PDAC.

Tumor progression

10.1002/cam4.5397

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FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis

Acta Pharmacologica Sinica (2023)

Depu Zhou Liancheng Deng Xiao Feng Huijing Xu Ye Tian

Abstract Doxorubicin is a common chemotherapeutic agent in clinic, but myocardial toxicity limits its use. Fibroblast growth factor (FGF) 10, a multifunctional paracrine growth factor, plays diverse roles in embryonic and postnatal heart development as well as in cardiac regeneration and repair. In this study we investigated the role of FGF10 as a potential modulator of doxorubicin-induced cardiac cytotoxicity and the underlying molecular mechanisms. Fgf10 +/− mice and an inducible dominant negative FGFR2b transgenic mouse model ( Rosa26 rtTA ; tet(O)sFgfr2b ) were used to determine the effect of Fgf10 hypomorph or blocking of endogenous FGFR2b ligands activity on doxorubicin-induced myocardial injury. Acute myocardial injury was induced by a single injection of doxorubicin (25 mg/kg, i.p.). Then cardiac function was evaluated using echocardiography, and DNA damage, oxidative stress and apoptosis in cardiac tissue were assessed. We showed that doxorubicin treatment markedly decreased the expression of FGFR2b ligands including FGF10 in cardiac tissue of wild type mice, whereas Fgf10 +/− mice exhibited a greater degree of oxidative stress, DNA damage and apoptosis as compared with the Fgf10 +/+ control. Pre-treatment with recombinant FGF10 protein significantly attenuated doxorubicin-induced oxidative stress, DNA damage and apoptosis both in doxorubicin-treated mice and in doxorubicin-treated HL-1 cells and NRCMs. We demonstrated that FGF10 protected against doxorubicin-induced myocardial toxicity via activation of FGFR2/Pleckstrin homology-like domain family A member 1 (PHLDA1)/Akt axis. Overall, our results unveil a potent protective effect of FGF10 against doxorubicin-induced myocardial injury and identify FGFR2b/PHLDA1/Akt axis as a potential therapeutic target for patients receiving doxorubicin treatment.

10.1038/s41401-023-01101-x

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Expression characteristic, immune signature, and prognosis value of EFNA family identified by multi-omics integrative analysis in pan-cancer

BMC Cancer (2022)

Zonglin Jiao Xiao Feng Yuqing Cui Lei Wang Junqing Gan

Abstract Background EphrinA (EFNA) are Eph receptor ligands that regulate various disease processes. Nonetheless, the expression characteristics of EFNAs in pan-cancer, their relationship with tumor immune microenvironment, and prognostic value landscape remain unknown. Methods A comprehensive landscape of EFNAs was created using various statistical data extracted from 33 cancers. Subsequently, we identified differential expression, genetic variations, potential function enrichment, tumor immune-related analysis, and drug sensitivity. Further, we investigated the clinical features and diagnostic prognostic value of EFNAs. RT-qPCR, western blot and immunohistochemistry (IHC) were used to validate the expression level and significant clinical value of EFNA5 in lung adenocarcinoma cell lines and tissues. Results EFNAs were highly mutated in various cancers. Genomic and epigenetic alterations of EFNAs were observed in various tumors, where an oncogenic mutation in specific cancer types potentially affected EFNA expression. Moreover, tumor-derived EFNAs were significantly related to the tumor immune microenvironment, suggesting that they are promising therapeutic targets. The majority of EFNA family genes were significantly linked to patient prognosis. Eventually, EFNA5 was an independent prognostic factor in lung adenocarcinoma. Conclusion In summary, EFNAs are crucial in tumor immune regulation, and EFNA5 is a prognostic marker in lung adenocarcinoma. Our findings provide new insights into EFNAs from a bioinformatics standpoint and highlight the significance of EFNAs in cancer diagnosis and treatment.

Surgical oncology

Omics

Signature (topology)

Value (mathematics)

Expression (computer science)

10.1186/s12885-022-09951-0

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Fracture Model of the Failure Wave in the Shocked Brittle Materials

Advanced materials research (2012)

Guo Wen Yao Zheng Jie Zhou Xiao Feng

A new failure model was developed to describe the failure wave formation and propagation in shocked glass. The progressive percolation of microcracks into the stressed body gives rise to the failure wave phenomenon which could be regarded as a diffusion process. The propagation of failure front is governed by a nonlinear diffusion equation. The dynamic damage constitutive relation is built up to compute the stress state in the material through the failure process. Numerical results are presented and compared to lateral stress gauge measurements in shocked glasses. It is shown that the proposed model can capture the essence of the failure wave phenomenon.

Brittleness

Percolation (cognitive psychology)

Material failure theory

10.4028/scientific5/amr.446-449.3718

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Characterization of the prognostic and diagnostic values of ALKBH family members in non-small cell lung cancer

Pathology - Research and Practice (2022)

Lei Wang Xiao Feng Zonglin Jiao Junqing Gan Qingwei Meng

10.1016/j.prp.2022.153809

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MSCT findings of lung large cell neuroendocrine carcinoma

Zhongguo yixue yingxiang jishu (2013)

Jian Guo Zhao Xiang Ye Xiao Feng Quan Le Yin

Objective To observe MSCT findings of lung large cell neuroendocrine carcinoma(LCNEC).Methods MSCT and pathologic findings of 27 patients with LCNEC were reviewed.All patients received plain CT,while 20 of them received enhanced CT scan.Results LCNEC presented as single lung mass in 23 patients,while as multiple nodules of unilateral lung in 4 patients,which located peripherally in 26,but centrally only 1 patient,with diameters ranged from 1.2 to 14.2 cm(average [5.2±2.1]cm).The tumors were smooth and well defined in 20 cases(20/27,74.07%),while necrosis was found in 9 cases(9/27,33.33%)and calcification was detected in 2 cases(2/27,7.41%).Lobulation of tumors was noticed in 19 cases(19/27,70.37%),spiculation was observed in 13 cases(13/27,48.15%),while vacuoles,pleural traction,obstructive atelectasis or pneumonia were found in 3(3/27,11.11%),7(7/27,25.93%)and 4 cases(4/27,14.81%),respectively.After injection of contrast agent,irregular enhancement of tumors was observed in all 20 cases that underwent enhanced CT scan.Mediastinal or hilar lymphadenectasis were observed in 14 cases(14/27,51.85%),among which 8 cases were proved as metastasis.Adjacent chest wall invasion,bone metastasis or brain metastasis was detected in 1 case(1/27,3.70%),respectively.While whole body metastasis was found in 1 case(1/27,3.70%).Conclusion The imaging features of LCNEC were very complicated and lack of characteristic.The final diagnosis depends on combining imaging and pathology.

Atelectasis

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[Distant Metastasis and Survival Outcomes after Computed Tomography-guided Needle Biopsy in Stage I-II Non-small Cell Lung Cancer].

DOAJ (DOAJ: Directory of Open Access Journals) (2017)

Jingli Fan Keke Zhai Tingting Ren Xiao Feng Lin Sui

Computed tomography-guided needle biopsy (CTNB) is a well-established and commonly used technique for diagnosing pulmonary nodules with high accuracy and safety. Needle-tract implantation after CTNB has been reported in various reports. The aim of this study is to evaluate whether preoperative CTNB affected the distant metastasis and overall survival in pathological stage I-II lung cancer patients.A total of 1,234 patients with pathological stage I-II non-small cell lung cancer were collected. 113 patients received preoperative CTNB, and 1,121 patients did not receive any biopsy before surgical resection. Propensity score-matching method was adopted to balance observed covariates between two groups, 113 pairs were matched. Cox regression analysis and Kaplan-Meier estimates were used to process survival analysis.Distant metastasis free survival (DMFS) was significantly poorer in the preoperative CTNB group than in the non-biopsy group (P=0.032). But there was no difference in the overall survival between the two groups (P=0.086).CTNB increased the risk of distant metastasis, not increasing the risk of mortality.背景与目的 CT引导下穿刺活检（computed tomography-guided needle biopsy, CTNB）是诊断肺癌最常用的一种方法，具有诊断准确性高及并发症少的特点。现有的研究表明CTNB可引起肿瘤的针道转移，然而极少有研究关注CTNB对远处转移和远期生存的影响。本研究旨在探讨术前的CTNB对I期-II期非小细胞肺癌（non-small cell lung cancer, NSCLC）远处转移和生存的影响。方法研究对象为1,234例I期-II期NSCLC术后患者，其中113例术前行CTNB，1,121例术前未经任何活检。应用倾向性评分匹配方法平衡两组间的临床特征，经配对后纳入后续统计检验共226例。并进一步应用Cox回归分析法和Kaplan-Meier分析法进行生存分析。结果在I期-II期NSCLC患者中，术前的CTNB组无远处转移时间（distant metastasis free survival, DMFS）显著短于无活检组（P=0.032），而两组间总生存无统计学差异（P=0.086）。结论 CT引导下穿刺肺活检可能促进早期肺癌的远处转移，但不影响总生存。.

Lung biopsy

10.3779/j.issn.1009-3419.2017.03.07

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Citations (2)