Serena Di Martino

University of Catania

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Filippo Drago

University of Catania

Vincenzo Micale

University of Catania

Claudio D’Addario

University of Teramo

Martina Di Bartolomeo

Fondazione IRCCS Istituto Nazionale dei Tumori

TŠ

Tibor Štark

Max Planck Institute of Psychiatry

Saverio Florio

University of Bari Aldo Moro

Claudio Bucolo

University of Catania

Vito Capriati

University of Bari Aldo Moro

Alessandro Abbotto

University of Milano-Bicocca

AČ

Andrea Čerňanová

Slovak Medical University

Cooperative Institutions

University of Catania

University of Milan

University of Padua

University of Naples Federico II

University of Pisa

University of Bologna

University of Ferrara

Federico II University Hospital

National Research Council

Istituto di Chimica Biomolecolare

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Deprotonation of Oxazolinyloxiranes: Formation of Substituted Acyloxiranes

European Journal of Organic Chemistry (1999)

Saverio Florio Vito Capriati Serena Di Martino Alessandro Abbotto

Deprotonation of oxazolinyloxiranes 1a, 1h, and 1k with sBuLi/TMEDA at –100 °C in Et2O furnishes oxazolinyloxiranyllithium compounds[1]1b, 1i, and 1l which are stable at low temperature and can be trapped with electrophiles to give substituted oxiranes 1c–1g and 1j. The reaction of 1b with aldehydes produced diastereomers syn (2a–d) and anti (3a–d). Oxiranyllithium 1i from trans-1-(4,4-dimethyl-2-oxazolinyl)-2-p-tolylepoxyethane (1h) was found to be configurationally stable while oxiranyllithium 1l, generated from the cis isomer 1k, was not. Oxazolinylepoxides 1d, 1j, and 1m could be deblocked to acyloxiranes 5a–e through oxazolidines 4a–e.

Diastereomer

10.1002/(sici)1099-0690(199902)1999:2<409::aid-ejoc409>3.0.co;2-z

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Citations (17)

ChemInform Abstract: Deprotonation of Oxazolinyloxiranes. Formation of Substituted Acyloxiranes.

ChemInform (1999)

Saverio Florio Vito Capriati Serena Di Martino Alessandro Abbotto

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

10.1002/chin.199925090

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Deprotonation of Oxazolinyloxiranes: Formation of Substituted Acyloxiranes

European Journal of Organic Chemistry (1999)

Saverio Florio Vito Capriati Serena Di Martino Alessandro Abbotto

10.1002/(sici)1099-0690(199902)1999:2<409::aid-ejoc409>3.3.co;2-q

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DNA methylation at cannabinoid type 1 and dopamine D2 receptor genes in saliva samples of psychotic subjects: Is there an effect of Cannabis use?

Pharmacological Research (2024)

Martina Di Bartolomeo Andrea Čerňanová Veronika Petrušová Serena Di Martino Július Hodosy

Psychosis is a characterizing feature of many mental disorders that dramatically affects human thoughts and perceptions, influencing the ability to distinguish between what is real and what is not. Both genetic and environmental factors, such as stressful events or drug use, play a pivotal role in the development of symptomatology and therefore changes in the epigenome may be of relevance in modeling a psychotic phenotype. According to the well-documented dysregulation of endocannabinoid and dopaminergic system genes in schizophrenia, we investigated DNA methylation cannabinoid type 1 receptor (CNR1) and dopamine D2 receptor (DRD2) genes in saliva samples from psychotic subjects using pyrosequencing. The epigenetic mark was significantly higher and directly correlated for both genes in psychotic subjects compared to healthy controls. We also showed that these DNA methylation levels were lower in psychotic subjects reporting current delta-9-tetrahydrocannabinol (THC) consumption, a well-known risk factor for developing psychosis throughout the lifespan, resembling those of controls at least for the DRD2 gene. Overall, our data confirm the key role of CNR1 and DRD2 gene regulation in psychosis and suggest DNA methylation levels at specific CpG sites as potential biomarkers, but just in those psychotic subjects not consuming THC.

10.1016/j.phrs.2024.107343

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Fluoxetine Protects Retinal Ischemic Damage in Mice

Pharmaceutics (2023)

Giovanni Luca Romano Lucia Gozzo Oriana Maria Maurel Serena Di Martino Valentina Riolo

To evaluate the neuroprotective effect of the topical ocular administration of fluoxetine (FLX) in a mouse model of acute retinal damage.Ocular ischemia/reperfusion (I/R) injury in C57BL/6J mice was used to elicit retinal damage. Mice were divided into three groups: control group, I/R group, and I/R group treated with topical FLX. A pattern electroretinogram (PERG) was used as a sensitive measure of retinal ganglion cell (RGC) function. Finally, we analyzed the retinal mRNA expression of inflammatory markers (IL-6, TNF-α, Iba-1, IL-1β, and S100β) through Digital Droplet PCR.PERG amplitude values were significantly (p < 0.05) higher in the I/R-FLX group compared to the I/R group, whereas PERG latency values were significantly (p < 0.05) reduced in I/R-FLX-treated mice compared to the I/R group. Retinal inflammatory markers increased significantly (p < 0.05) after I/R injury. FLX treatment was able to significantly (p < 0.05) attenuate the expression of inflammatory markers after I/R damage.Topical treatment with FLX was effective in counteracting the damage of RGCs and preserving retinal function. Moreover, FLX treatment attenuates the production of pro-inflammatory molecules elicited by retinal I/R damage. Further studies need to be performed to support the use of FLX as neuroprotective agent in retinal degenerative diseases.

10.3390/pharmaceutics15051370

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Early Blockade of CB1 Receptors Ameliorates Schizophrenia-like Alterations in the Neurodevelopmental MAM Model of Schizophrenia

Biomolecules (2022)

Tibor Štark Fabio Arturo Iannotti Serena Di Martino Martina Di Bartolomeo Jana Kučerová

In agreement with the neurodevelopmental hypothesis of schizophrenia, prenatal exposure of Sprague-Dawley rats to the antimitotic agent methylazoxymethanol acetate (MAM) at gestational day 17 produces long-lasting behavioral alterations such as social withdrawal and cognitive impairment in adulthood, mimicking a schizophrenia-like phenotype. These abnormalities were preceded at neonatal age both by the delayed appearance of neonatal reflexes, an index of impaired brain maturation, and by higher 2-arachidonoylglycerol (2-AG) brain levels. Schizophrenia-like deficits were reversed by early treatment [from postnatal day (PND) 2 to PND 8] with the CB1 antagonist/inverse agonist AM251 (0.5 mg/kg/day). By contrast, early CB1 blockade affected the behavioral performance of control rats which was paralleled by enhanced 2-AG content in the prefrontal cortex (PFC). These results suggest that prenatal MAM insult leads to premorbid anomalies at neonatal age via altered tone of the endocannabinoid system, which may be considered as an early marker preceding the development of schizophrenia-like alterations in adulthood.

AM251

10.3390/biom12010108

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Citations (12)