Edward Newman

Glasgow Royal Infirmary

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John Paul Leach

University of Glasgow

Donald G. Grosset

University of Glasgow

Krishna Dani

Queen Elizabeth University Hospital

Hadi Manji

University College London

Veerle Visser‐Vandewalle

University of Cologne

Alfons Schnitzler

Heinrich Heine University Düsseldorf

David Arkadir

Hebrew University of Jerusalem

Steffen Paschen

Kiel University

Joachim K. Krauss

Medizinische Hochschule Hannover

Tomasz Mandat

The Maria Sklodowska-Curie National Research Institute of Oncology

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University College London

National Hospital for Neurology and Neurosurgery

University of Glasgow

King's College London

Queen Elizabeth University Hospital

National Health Service

University College London Hospitals NHS Foundation Trust

University of Edinburgh

University of Oxford

Imperial College London

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887-3 What proportion of patients with heart failure and preserved left ventricular systolic function has an elevated plasma concentration of B-type natriuretic peptide?

Journal of the American College of Cardiology (2004)

Karen Hogg Esther Rooney Eileen Lundmark James H. Christie Edward Newman

Ventricular Function

10.1016/s0735-1097(04)91028-5

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Attitudes of superintendents of institutions for the mentally retarded towards deinstitutionalization

International Journal of Rehabilitation Research (1985)

Adital Ben Ari Jim Conroy Malca Molcho Edward Newman Shunit Reiter

Ari, Adital Ben; Conroy, Jim; Molcho, Malca; Newman, Edward; Reiter, Shunit Author Information

Mentally retarded

10.1097/00004356-198509000-00005

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Accuracy of Parkinson's disease diagnosis in 610 general practice patients in the West of Scotland

Movement Disorders (2009)

Edward Newman Kieran C. Breen J. Patterson Donald M. Hadley Katherine A. Grosset

UK-based community studies have found high rates of misdiagnosis in Parkinson's disease (PD). Searches of prescription databases and case records identified 610 patients taking antiparkinson therapy for a PD diagnosis in 92 West of Scotland General Practices. Patients with no documented progression of parkinsonism and/or no increase in antiparkinson medication for 3 years were assessed by two movement disorder specialists. FP-CIT SPECT scanning was performed in clinically uncertain cases. Those considered unlikely to have PD had antiparkinson drugs tapered then stopped, with a minimum of 6 months follow-up. Age, sex and disease duration matched controls were also assessed. 64 of 89 (71.9%) patients meeting selection criteria were assessed, of whom 36 (56.3%) were appropriate for therapy withdrawal. Thirty three of those 36 patients (91.7%) and 3 of 64 (4.7%) controls stopped antiparkinson therapy without deterioration giving an overall total of 36 of 610 (5.9%). The revised diagnoses in this group were mainly essential tremor (ET) (n = 14) and vascular parkinsonism (VP) (n = 10). Patients managed in Primary Care were significantly more likely to complete therapy withdrawal than those attending a specialist clinic (15.3% vs. 2.6%, P < 0.0001). The total annual cost of antiparkinson medication for these 36 patients was 13,400 pounds; the mean duration of diagnosis was 6.8 years (SD 5.6). At least 1 in every 20 patients taking medication for PD is misdiagnosed. Nearly all of these patients can be identified by simple screening of prescription databases and case records in Primary Care, followed by clinical review, which allows withdrawal of unnecessary medication.

10.1002/mds.22829

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Thinking outside of the box

Practical Neurology (2011)

Edward Newman Sarah Cooper Ravi Jampana John Paul Leach

A 37-year-old man presented after developing horizontal double vision while driving, 10 days after surgery for metastatic oral cancer. He also reported a dull frontal headache and pulsatile tinnitus while lying flat for several days, preceding the double vision. The headache was worse in the mornings. He denied any visual blurring or obscurations. The double vision had persisted and was worse when he looked into the distance. Eighteen months previously he had been diagnosed with squamous carcinoma of the tongue and had undergone local surgical excision. Recently, metastatic spread to a left cervical lymph node was confirmed. CT scanning did not show any local recurrence. Subsequent radical neck dissection did not demonstrate further spread to other lymph nodes. There was no other significant medical history and he was taking codydramol and diclofenac for the combination of postoperative wound discomfort and headache. There had been no other recent drug use. He was a smoker. He originated from Pakistan and had lived in the UK for 13 years with his wife and son, who were well. This patient's general practitioner referred him urgently to ophthalmology. Examination demonstrated a thin man with normal visual acuity and colour vision (as tested with Ishihara plates). Abduction of the left eye was impaired but other eye movements were full. Ophthalmoscopy revealed moderately severe bilateral optic disc swelling with disc haemorrhages and marked peripapillary oedema (figure 1). Goldmann visual fields displayed minimal enlargement of blind spots bilaterally. Figure 1 Funduscopy showing bilateral optic disc swelling with haemorrhages. ### Question 1 Summarise the findings and consider which further investigations you would request The nature of this man's headache suggests raised intracranial pressure. The binocular, horizontal diplopia, worse when viewing …

10.1136/jnnp.2010.235853

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Elevated serum urate concentration independently predicts poor outcome following stroke in patients with diabetes

Diabetes/Metabolism Research and Reviews (2005)

Edward Newman Fariel S. Rahman Kennedy R. Lees Christopher J. Weir Matthew R. Walters

Abstract Background Type 2 diabetes is a risk factor for stroke and confers increased risk of poor outcome and further vascular events following stroke. Hyperuricaemia occurs commonly in patients with type 2 diabetes, but its significance as a predictor of outcome following stroke is uncertain. We sought to investigate the prognostic significance of elevated serum urate concentration in diabetic subjects following stroke. Methods We studied a cohort of type 2 diabetes patients presenting to our unit with computed tomography‐confirmed acute stroke. Fasting blood samples were drawn within 24 h of admission for urate concentration and standard battery of biochemistry and hematological tests. Information on age, stroke type, prior hypertension, smoking status, resolution time of symptoms and National Institutes of Health Stroke Score was collated. The main outcome event was time to myocardial infarction, recurrent stroke or vascular death, as defined in the CAPRIE trial. Stepwise proportional hazards regression was used to estimate the effect of the above variables on event‐free survival following stroke. Results One hundred and forty patients were studied. Median follow‐up duration was 974 days (IQR 163 to 1830 days). Sixty‐four patients suffered an outcome event. Urate levels of greater than 0.42 mmol/L ( p < 0.001) and an increasing NIHSS score ( p < 0.001) independently predicted increased likelihood of suffering an event. Conclusion Elevated urate concentration is significantly and independently associated with increased risk of future vascular events in diabetic stroke patients. Further studies to elucidate the mechanism of this observation are required. Copyright © 2005 John Wiley & Sons, Ltd.

Stroke

10.1002/dmrr.585

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Geographical difference in Parkinson's disease prevalence within West Scotland

Movement Disorders (2008)

Edward Newman Katherine A. Grosset Donald G. Grosset

The wide range in reported prevalence of Parkinson's disease (PD) in the United Kingdom (between 108 and 164 per 100,000) is usually attributed to differences in study methodology. We report prevalence of PD in four geographic areas within West Scotland, which was calculated using the same methodology, from prescription database searches within primary care, combined with full case record review. Crude prevalence was 119.2 per 100,000 (95% CI 109.7-128.6) and age-adjusted prevalence was 129.5 (95% CI 119.6-139.4) in 92 General Practices covering a population of 511,927. Prevalence was significantly lower in South Glasgow (men 98.3, CI 78.7-117.9; women 83.9, CI 65.6-102.2) than South Lanarkshire (men 202.7, CI 175.0-230.4; women 151.1, CI 127.7-174.5), age-adjusted rates, both P < 0.001. Factors associated with higher prevalence of PD, such as lower cigarette smoking rates, higher education level, and rural living, were higher in South Lanarkshire than South Glasgow, but the magnitude of the difference was greater than expected considering studies describing relative risk for these factors. Access to services, and specialist clinic attendance were both higher for South Glasgow, which may influence diagnostic accuracy, time to diagnosis, and time to initiating antiparkinson therapy. Exploration of these factors is justified to explain further such wide variation in PD prevalence.

Attendance

Smoking prevalence

Prevalence

10.1002/mds.22359

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Prevalence and diagnosis of Parkinson's disease : a community study.

Edward Newman

Clinicopathological and community studies have demonstrated misdiagnosis in Parkinson’s disease (PD). Clinical trials of antiparkinson medication have also shown a subset of patients labelled as having PD have normal functional brain dopaminergic imaging. Conditions commonly misdiagnosed as PD include Essential tremor (ET), vascular Parkinsonism (VP) and dystonic tremor (DT). This thesis examines the accuracy of clinical diagnosis of PD in a community setting by identifying misdiagnosed cases and supervising antiparkinson medication withdrawal. Prescription database searches and GP case record review were carried out in 92 West Scotland GP practices within a population of 511,927. 610 patients on antiparkinson medication for a PD diagnosis were identified and age-adjusted prevalence was 129.5 per 100,000. Patients were invited for assessment if there was (a) no increase in dopaminergic drug dose or (b) no recorded progression of disease over time, suggestive of possible misdiagnosis. 64 patients were assessed and this was supplemented with FP-CIT SPECT scanning in 25 uncertain cases. Patients considered unlikely to have PD were advised to reduce and discontinue antiparkinson drugs, with repeat PD motor scoring over 6 months. 33 of 64 patients (51.6%) successfully completed antiparkinson medication withdrawal. An age, sex and disease duration matched control group was also assessed. The selection criteria allowed identification of a high proportion of misdiagnosed cases and FP-CIT SPECT was a useful diagnostic tool for assessing patients (previously diagnosed as PD) in whom there was diagnostic doubt.

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Vocational Rehabilitation Systems and Structures: A Bi-National Look

Routledge eBooks (2021)

Shunit Reiter Diane Nelson Bryen Edward Newman Yecheskel Taler

This chapter describes two contrasting organizational systems and structures in vocational rehabilitation settings in Israel and in the United States. A common outlook exists in the two countries on a conceptual definition, criteria of client success, and stages of the rehabilitation process. The notion that the rehabilitation process is not unidirectional is accepted by both countries. The organization and structure of the rehabilitation system is no less crucial for the success of the service. Vocational rehabilitation services are provided within human service organizations which may lack a clear concept of organizational effectiveness, more specifically, a consensus as to what constitutes successful client outcomes. The formal structure of the organization of the rehabilitation system is not always determined by demands emanating from assessed client needs or from current rehabilitation practices, but by policy makers who are generally removed from these needs and practices. The National Insurance Institute (Nil) provides social security payments to special groups in the population.

Vocational Rehabilitation

10.4324/9781003110569-8

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The future of rehabilitation

Willan eBooks (2012)

Edward Newman

10.4324/9780203722855-102

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Neurological Scottish neologisms

Practical Neurology (2019)

John Paul Leach Krishna Dani Niall MacDougall Paul Gallagher Edward Newman

In 1983, Douglas Adams and John Lloyd published The Meaning of Liff ,1 a magnificent and hugely successful humourous book in which hundreds of common experiences, emotions, objects and situations were assigned UK place names (figure 1). Some of our personal favourites include the following: Figure 1 The (original) meaning of Liff book. In this article, we have compiled a number of Scottish place names (figure 2) that have now become attached to some classic phenomena of neurological practice. We exhort other areas to evolve their neurovocabulary. Figure 2 Map of Scotland illustrating our Liff locations. 1. Menzies (n.): the general practitioner who disagrees with the functional neurological disorder diagnosis because he ‘knows the family very well’. 2. Dufftown (verb (v.)): listening to the patient’s relatives telling you all about their own illness. 3. Bonkle …

Neologism

10.1136/practneurol-2019-002426

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