Kazuhisa Ishi

Juntendo University Urayasu Hospital

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Fujihiko Suzuki

Juntendo University Urayasu Hospital

Junichi Koyatsu

Social Insurance Saitama Chuo Hospital

Katsunari Kina

Juntendo University

Akira Saito

Saitama Medical University

Masanori Nojima

The University of Tokyo

Takeyoshi Kubota

Juntendo University Urayasu Hospital

Kazuyoshi Sugiyama

Juntendo University Urayasu Hospital

Yoshihiro Yagi

University of Washington Tacoma

Akio Kidokoro

Juntendo University Urayasu Hospital

Reiko KAZAMA

Institute of Clinical Research

Cooperative Institutions

Juntendo University

Juntendo University Urayasu Hospital

The University of Tokyo

Juntendo University Hospital

The University of Texas MD Anderson Cancer Center

Massachusetts General Hospital

Hokkaido University

Institute of Clinical Research

Kyoto University

University of Massachusetts Boston

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Development of cell collection techniques for bile juice preparation

The Journal of the Japanese Society of Clinical Cytology (2011)

Atsushi Furuhata Yasuaki Hirooka Toshiharu Matsumoto Kazuhisa Ishi Yasuko TOI

目的 : 胆汁中の細胞を効率よく回収するための集細胞処理法について検討した.方法 : 胆嚢結石症 25 例の摘出胆嚢壁の擦過細胞を胆嚢内胆汁と各種処理液との等量混合液に一定量加えた. 遠心後の沈渣全量をサイトスピンにて塗抹標本とし, 95%エタノール固定, Papanicolaou 染色を行った. 用いた処理液は生理食塩液, ウシ血清アルブミン (BSA) 液, RPMI 1640 培地, 50%エタノール液, CytoRich®液, YM®液およびポストサンプラー®液である. 顕微鏡によるデジタル画像より上皮細胞数を算定し, 無添加胆汁に対する割合 (%) を増加率として求めた.成績 : 集細胞数は無添加胆汁に対し生理食塩液で 197%, RPMI 1640 培地で 297%, BSA 液で 326%, 50%エタノール液で 468%, CytoRich 液で 612%, YM 液で 658%, ポストサンプラー液で 653%と, すべての処理液で有意な増加を示した.結論 : いずれの処理液も高い増加率を示した. 特にアルコールを含む CytoRich 液, YM 液およびポストサンプラー液は優れた集細胞効果を示し, 標本作製時のアーチファクトの少ない診断の容易な胆汁標本の作製に有用と思われた.

Papanicolaou Test

10.5795/jjscc.50.95

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Cotyledonoid dissecting leiomyoma of the uterus: report of two cases

Archives of Gynecology and Obstetrics (2014)

Harumi Saeki Takayuki Suzuki Shigetaka Yamasaki Akane Hashizume Hiroshi Izumi

Smooth Muscle Tumor

Benign tumor

Uterine Leiomyoma

10.1007/s00404-014-3406-2

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Small cell carcinoma of the prostate with hypercalcemia

International Journal of Urology (2005)

Kisaburo Hanazawa Naotaka Higashi Yoshio Kawachi Fujihiko Suzuki Kazuhisa Ishi

Abstract We present a case of small cell prostate carcinoma with hypercalcemia in a 75‐year‐old man. He was diagnosed as having stage T3bN1M0 adenocarcinoma of the prostate. His serum prostate‐specific antigen level was reduced to below the normal range after a combination treatment of a luteinizing hormone‐releasing hormone agonist and flutamide for prostate carcinoma. He subsequently experienced increasing fatigue, poor appetite, short time loss of consciousness and pain in his lower abdomen. His serum calcium level and carcinoembryonic antigen were increased. He died 5 months from the start of treatment. The autopsy revealed small cell carcinoma of the prostate and multiple metastasis of the lung, liver, pancreas, lymph nodes and spine.

10.1111/j.1442-2042.2004.00977.x

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Inverted Transitional Cell Carcinoma of the Ureter

International Journal of Urology (1996)

Yoshio Kawachi Kazuhisa Ishi

An inverted urothelial tumor (transitional cell carcinoma, inverted type, grade 1), consisting of a large (3.5 ± 1.2 ± 1.2 cm) tumor with stalk (0.3 cm in diameter) and surrounding broad base polypoid foci (0.5 ± 0.6 ± 0.5 cm altogether), was found in the lower segment of the left ureter of a 59‐year‐old man. He has taken oral anticancer drugs and kanpo medicine as a follow‐up for 61 months, and is now free of disease. Differential diagnosis, inverted urothelial papilloma and carcinoma, and adequate treatment are discussed.

Inverted Papilloma

10.1111/j.1442-2042.1996.tb00543.x

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Letters to the Editors

Acta Cytologica (1999)

Uma Singhal Harsh Mohan Cristina A.T.S. Mitteldorf Antonio Carlos de Oliveira Misiara Iara Emiko de Carvalho

10.1159/000331317

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A case of AIDS detected at the department of otorhinolaryngology.

Practica Oto-Rhino-Laryngologica (1987)

Rinya Sugita Kazuhiro Teramoto Kazuhisa Ishi S Kawahata

A patient with the main complaint of pharyngeal pain who visited our otorhinolaryngology department as a result of many tests was diagnosed as having AIDS. The patient was a 42-year-old male who worked as a dancing instructor and was a homosexual. Tonsillar candidiasis, swelling of lymph glands in the cervical region, and dermal erythema in the neck were found. Blood tests showed a reduction in WBC, increase in the erythrocyte sedimentation rate (ESR), increased levels of immuno globulins IgA and IgG, reduction in T-cells, and a OKT4/OKT8 ratio of 0.2. The tuberculin response was negative and the HIV antibody titer was 320x. Pneumo cystis carinii and Kaposis salcoma were not present.

Erythema

Cervical lymph nodes

10.5631/jibirin.80.1651

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Solid Pseudopapillary Tumor of the Pancreas: Report of Four Cases

KARGER eBooks (2007)

Fujihiko Suzuki Kazuhisa Ishi Saori Shiono Atsushi Arakawa Hiroshi Izumi

Solid pseudopapillary tumor of the pancreas (SPTP) is a rare neoplasia of uncertain histogenesis, which usually occur in young females and is regarded as a tumor of low malignancy potential. We describe the histopathological features of four cases of this tumor and review the literature. All patients were female with ages ranging from 18 to 60 years (mean 35.2 years). Grossly, the tumors appeared as a solid cystic mass, frequently with hemorrhagic and necrotic areas; however, with a predominantly cystic formation in 1 case and of noncystic type in 1 case. The histological findings of the tumor cells were relatively uniform, showing solid and pseudopapillary or pseudoglandular proliferation and having few mitotic figures or nuclear pleomorphism. On immunohistochemical examination, all cases were similar to those previously reported as SPTP. In addition, all tumors showed low a Ki-67 index (1.0% of all tumor cells). One of four cases proved to be metastatic to lymph nodes. Despite metastasis, the proliferating ability of the tumor cells was relatively low and this patient is alive with no evidence of recurrence since surgery. SPTPs have distinctive morphologic and biologic features; therefore, it may be difficult to evaluate the malignancy potential by histological and immunohistochemical examination.

Histogenesis

Pleomorphism (cytology)

10.1159/000100561

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A CASE OF PRIMARY LEIOMYOSARCOMA IN THE INFERIOR VENA CAVA

The journal of the Japanese Practical Surgeon Society (1991)

Kazuyoshi Sugiyama Akio Kidokoro Yoshihiro Yagi H Shimota Kazuhisa Ishi

A 41-year-old woman was admitted to our hospital with the chief complaints of right lower abdominal pain andedema in the lower extermities. The diagnosis of gallstone disease associated with a retroperitoneal tumor of the infiltrated range was was made by using ultrasonography, computed tomography angiography. Primary tumor in the inferior vena cava or invasion of retroperitoneal tumor was suggested by postcavarography and magnetic resonanse imaging test. First of all, cholecystectomy was performed because of the complication of cholelithiasis. The tumor was a yellowish-white massive one with approx. 6 cm in diameter sitting to the lower surface of the liver, and internal and upper regions of the right kidney, and existed so as to eject from the inferior vena cava. The combined resection of the right kidney was performed, because resections of the partial postcaval walls and the tumor, and its ablastions were difficult. The double lineserial cross suture of the amputation stump of the inferior vena cava was carried out. The chemotherapy was concomitantly used as an auxotherapy. The postoperative couse was favorable, and the patient is under observation on ambulatory basis as of now progressed for 4 months. Eighteen cases of primary leiomyosarcoma in theinferior vena cava including this case have been reported in our country so faras we studied, and we also presented a discussion of some references because of its seldom occurrence.

Primary tumor

10.3919/ringe1963.52.1060

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Contents

Acta Cytologica (1998)

Gláucia Maria Machado‐Santelli Masuzo Kamiya Kunio Mizuguchi Makoto Yoshimoto Miyuki Tanaka

10.1159/000331813

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Cytodiagnosis of Placental Site Trophoblastic Tumor

Acta Cytologica (1998)

Kazuhisa Ishi Fujihiko Suzuki Akira Saito Junichi Koyatsu Satoshi Akutsu

Placental site trophoblastic tumor (PSTT) is a rare form of trophoblastic neoplasm. Approximately 100 cases of PSTT have been reported, but we found no report on its cytodiagnosis.Case 1, a 39-year-old female, came to the hospital because of abnormal genital bleeding. Case 2, a 36-year-old female came because of amenorrhea for a year. In both cases, endometrial smear and intrauterine curettage suggested trophoblastic disease, and hysterectomy was performed. Laboratory data revealed a mild increase in human chorionic gonadotropin (hCG) and beta-hCG but normal human placental lactogen (hPL). In the cytologic examination, the background contained some hemorrhagic and fibrinous areas but no necrosis. Most tumor cells stained light green, were round or polygonal, and contained abundant cytoplasm. Some were palely stained and had vacuoles. Some cells showed hyperchromatism, an irregular nucleus, fine-to-coarse chromatin granules and markedly different sizes. Most of the cells were hPL positive, and a few were hCG positive.Both cases were considered benign because of rare mitoses despite cellular pleomorphism. However, careful follow-up is required. The differential diagnosis of PSTT is difficult from cytologic and biopsy specimens alone but may be achieved with additional magnetic resonance imaging findings and positive staining of hPL and hCG.

Human placental lactogen

Trophoblastic Tumor

Human chorionic gonadotropin

Gestational Trophoblastic Disease

10.1159/000331838

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Citations (12)