Marı́a José Escribá

Instituto de Investigación Sanitaria La Fe

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Sonia Herraiz

Instituto de Investigación Sanitaria La Fe

Juana Crespo

Valencian Infertility Institute

María José de los Santos

Universitat de València

Anna Buigues

Instituto de Investigación Sanitaria La Fe

António Pellicer

Universitat de València

Gloria Calderón

Cambridgeshire and Peterborough NHS Foundation Trust

Xavier Vendrell

Sistemas Genómicos

Elena Labarta

Valencian Infertility Institute

N. Grau

Valencian Infertility Institute

Marina Benavent

Cooperative Institutions

Valencian Infertility Institute

Universitat de València

Instituto de Investigación Sanitaria La Fe

Guardia Civil

INCLIVA Health Research Institute

Istituto di Istruzione Superiore I.T.C. Di Vittorio

Universitat Politècnica de València

Universidade de Vigo

Barcelona IVI Clinic

Universitat Autònoma de Barcelona

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Nicotinamide mononucleotide supplementation improves oocyte developmental competence in different ovarian damage conditions

American Journal of Obstetrics and Gynecology (2025)

Noelia Ramírez-Martin Anna Buigues Cristina Rodríguez-Varela Jessica Martínez Paula Blázquez-Simón

Chemotherapy-induced ovarian damage represents a major challenge for women of reproductive age undergoing cancer treatments. In mice, nicotinamide mononucleotide (NMN) enhances the developmental competence of aged oocytes by preventing oxidative stress, inflammation, and apoptosis, however its potential to restore oocyte quality following chemotherapy-induced ovarian damage remains unexplored. To investigate the effects of NMN treatment against the deleterious effects of chemotherapy and aging in mice and human oocytes. We used mouse models with different degrees of chemotherapy-induced ovarian damage, mimicking diminished ovarian reserve (DOR) and premature ovarian insufficiency (POI), and young-healthy females as a reference group. Mice of each ovarian condition were treated with or without 2g/L NMN in drinking water for a complete cycle (4 weeks) or during the later stages (14 days) of folliculogenesis. After treatments, mice underwent ovarian hyperstimulation and were euthanized to collect ovaries and oocytes to evaluate follicular counts, oocyte quality, and maturation. Part of the collected metaphase II oocytes underwent in vitro fertilization (IVF) and embryo culture to assess preimplantation embryo development. Finally, we also explored the benefits of in vitro NMN supplementation in aged infertile patients using germinal vesicle (GV) oocytes from advance maternal age (AMA >38) and young (≤35 years old) women. Maturation and artificial oocyte activation potential were assessed following the GV rescue approach. NMN supplementation over a complete folliculogenesis cycle (4 weeks) improved the quality of oocytes exposed to chemotherapy by recovering nicotinamide adenine dinucleotide levels (p = 0.006), redistributing mitochondria to promote proper meiotic spindle assembly, and ultimately, recovering fertilization rate (p = 0.003) in DOR mice. In the POI model, reduced reactive oxygen species abundance (p = 0.039), increased mitochondria quantity (p = 0.030), and improved expression of the DNA repair gene Apex1 were found, thereby enhancing proper meiotic spindle formation and chromosome alignment. Similarly, when NMN supplementation was restricted to the later stages of folliculogenesis (14 days), positive effects on oocyte quality were observed, though to a lesser extent. Increased NAD+ levels (p ˂0.001) and embryo development rates (p = 0.048) were found in the DOR group, while reduced ROS abundance (p = 0.040), and increased mitochondrial DNA copy number (p = 0.006) and DNA repair gene expression (Apex1: p = 0.041; Alkbh2: p = 0.029) were observed in POI mice. Finally, in vitro NMN supplementation was able to improve the nuclear competence (p = 0.039) and parthenogenetic activation of immature oocytes from women with AMA (>38 years old). These results highlight the regenerative role of NMN in mouse and human oocytes exposed to the deleterious effects of chemotherapy and aging, representing a potential therapeutic alternative for fertility preservation and aged patients seeking to achieve motherhood with autologous oocytes.

Nicotinamide mononucleotide

10.1016/j.ajog.2025.02.006

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Comparison of the effect of two different handling media on rabbit zygote developmental ability

annales de biologie animale biochimie biophysique (2001)

Marı́a José Escribá Miguel Á. Silvestre Ayman M. Saeed F Garcı́a-Ximénez

HEPES

Rabbit (cipher)

10.1051/rnd:2001121

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Didáctica y Neurocognición de La Comunicación Oral y Escrita en Leguas Extranjeras

inBlue Editorial eBooks (2022)

Matilde De Léon Marisela Alfaro Yuliet Blanco Francisco Limonta Marı́a José Escribá

El presente texto titulado Didáctica y neurocognición de la comunicación oral y escrita para aprender lengua extranjera conduce al lector a la comprensión de la didáctica de la mediación constructivista y la neurocognición del aprendizaje de lengua extranjera y en ese propósito los autores dejan claridad del propósito al precisar que conlleva un proceso de autorregulación en el aprendiz, por lo que esa dinámica, apunta a generar un proceso autónomo en los estudiantes.

10.56168/ibl.ed.167850

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Human blastocysts derived from monopronuclear zygotes: a biological model for the study of ploidy, euploidy, topography and heteroparental inheritance

Fertility and Sterility (2019)

N. Grau Nuria Soler Ana González-Picazo Xavier Vendrell Marı́a José Escribá

Inner cell mass

10.1016/j.fertnstert.2019.07.250

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CAN CHLOE (AN AI-BASED EMBRYOLOGIST ASSISTANT) AUTOMATICALLY PREDICT ON DAY 3 WHETHER AN EMBRYO WILL BECOME A BLASTOCYST, BE UTILISED AND/OR IMPLANT?

Fertility and Sterility (2022)

J.L. Teruel Clara Miret Lucio Marta Lozano Marina Benavent Marı́a José Escribá

Blastocyst Transfer

10.1016/j.fertnstert.2022.08.346

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El programa valenciano para la preservación de la fertilidad

María José de la Pascua Sánchez Vicente Mirabet Pilar Alamá Ana Carolina Rosa Silva Marı́a José Escribá

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Comparative single-cell transcriptomic profiles of human androgenotes and parthenogenotes during early development

Fertility and Sterility (2022)

Pedro de Castro Xavier Vendrell L. Escrich N. Grau Roberto González-Martín

Cell synchronization

10.1016/j.fertnstert.2022.12.027

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Morphokinetic analysis and embryonic prediction for blastocyst formation through an integrated time-lapse system

Fertility and Sterility (2015)

Y. Motato María José de los Santos Marı́a José Escribá B. Aparicio Ruiz José Remohı́

10.1016/j.fertnstert.2015.11.001

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Conización con asa de diatermia o LLETZ

Enfermería integral: Revista científica del Colegio Oficial de Enfermería de Valencia (2016)

Marı́a José Escribá Antonia Laserna Monterde Ma Gracia Garrido Escrivá

La conizacion es una intervencion diagnostico-terapeutica que se utiliza para extirpar un fragmento del cuello uterino que incluya la zona de transformacion o ZT, ubicacion en la que se origina la mayor parte de los canceres de cervix. Con este trabajo se pretende hacer un breve recordatorio sobre el VPH y el cancer de cervix, su prevencion, diagnostico y tratamiento quirurgico, centrandonos en la escision amplia de la ZT con asa de diatermia o LLETZ. Se trata de una intervencion quirurgica sin caracter de urgencia que generalmente no requiere ingreso hospitalario de mas de un dia, y cuya recuperacion suele ser indolora. Tambien se explica como realizar el marcaje de la pieza extirpada para el analisis citopatologico, las contraindicaciones de esta intervencion y la mayor incidencia de parto prematuro en mujeres que han sido intervenidas previamente

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Viable offspring derived from cryopreserved haploid rabbit parthenotes

Theriogenology (2002)

F Garcı́a-Ximénez Marı́a José Escribá

Parthenogenesis

Blastomere

10.1016/s0093-691x(01)00718-x

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Citations (8)