Yoshiaki Kumamoto

Kao Corporation (Japan)

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Testicular Findings, Endocrine Features and Therapeutic Responses of Men with Acquired Hypogonadotropic Hypogonadism

International Journal of Urology (1998)

Hitoshi Tachiki Naoki Ito Hiroshi Maruta Yoshiaki Kumamoto Taiji Tsukamoto

Men with acquired hypogonadotropic hypogonadism (AHH) who desire restoration of fertility are treated with exogenous gonadotropin. However, gonadotropin (Gn) therapy does not always restore testicular function. It is unknown whether the therapeutic responses to Gn therapy correlate with their testicular histological findings. Thus, we analyzed factors influencing testicular dysfunction and therapeutic responses in AHH.Of 21 men with AHH, 11 had no postmeiotic germ cells and were classified as the severe spermatogenic failure group. These were compared with the other 10 patients who had postmeiotic germ cells and comprised the mild spermatogenic failure group.Testicular volume and tubular diameter were significantly smaller, and the basement membrane and tunica propria were significantly thicker in the severe failure group. The gonadotropin basal level and response to exogenous gonadotropin-releasing hormone, and the testosterone response to exogenous human chorionic gonadotropin were significantly lower in the severe failure group of patients. Also, the recovery of spermatogenesis and testosterone secretory potentials was poor in the cases with a duration between diagnosis and treatment of 2 years or more.Longer periods without treatment may be responsible for irreversible testicular dysfunction in AHH. Gn therapy should be initiated very soon after the diagnosis of AHH if fertility is desired.

10.1111/j.1442-2042.1998.tb00244.x

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Citations (11)

Studies on the Production Rate of Estradiol in the Testis in Male

Folia Endocrinologica Japonica (1992)

Y Kumamoto Naoki Itoh Yoshiaki Kumamoto Hiroshi Maruta

It is surmised that studies on the relationship between the endocrinological milieu and therapeutic efficacy in male infertile patients are essential in elucidating the etiology of this disease and devising effective therapeutic methods. The relation between serum gonadotropin level and therapeutic efficacy has already been reported. In the present study, we investigated the basal levels of two sex steroids, i.e., testosterone and estradiol, and the estradiol:testosterone (E2/T) ratio, and also the increases in these parameters after the administration of hCG to human subjects presenting various degrees of testicular dysfunction, e.g., male infertile patients, aged males, Klinefelter's syndrome and hypogonadotropic hypogonadism. Special attention was given to the characteristics of the reserve capacity for secretion of estradiol in male infertile patients. The hCG test was performed on a total 527 subjects, including 65 normal adult males. The reserve capacity for the secretion of estradiol was investigated on the basis of the increasing rate in the serum E2/T ratio. The increasing rate in the serum E2/T ratio was statistically larger in subfertile males, oligozoospermia and azoospermia in comparison with the normal adult males. On the other hand, the aged males did not show any difference from the normal adult males, whereas the results were significantly lower in the male subjects with Klinefelter's syndrome and hypogonadotropic hypogonadism. It was considered that the increase in the serum E2/T ratio is one characteristic of the gonads of male infertile patients. The results of multiple regression analysis showed that the LH level, the pretreatment sperm concentration and the increasing rate in the serum E2/T ratio were important factors determining the increase in the sperm concentration after treatment. Accordingly, for cases of oligozoospermia characterized by an LH level of 13.7mIU/ml or less and a sperm concentration of 5 x 10(6)/ml or more, the relationship between the increasing rate in the serum E2/T ratio and therapeutic efficacy was investigated. It was found that the increasing rate in the serum E2/T ratio was significantly greater in the therapeutically ineffective cases compared with the therapeutically effective cases. On the basis of this finding, it was surmised that the percentage increase in the serum E2/T ratio is one index reflecting testicular function. In addition, for cases of oligozoospermia characterized by an LH level of 13.7mIU/ml or less, a sperm concentration of 5 x 10(6)/ml or more and the increasing rate in the serum E2/T ratio of 4.01 or less, the relationship between the degree of spermatogenesis and therapeutic efficacy was investigated.(ABSTRACT TRUNCATED AT 400 WORDS)

Basal (medicine)

Klinefelter syndrome

Gonadotropin

Etiology

10.1507/endocrine1927.68.12_1276

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Citations (1)

SELECTION OF HIGHLY METASTATIC LINES FROM STREPTOZOTOCIN-INDUCED MOUSE RENAL ADENOCARCINOMA AND THEIR IN VIVO METASTATIC OR IN VITRO INVASIVE POTENTIAL

The Japanese Journal of Urology (1991)

Noriomi Miyao Yoshiaki Kumamoto Taiji Tsukamoto Noriyuki Otani

We selected highly metastatic lines from mouse renal adenocarcinoma (STZ-RCC) chemically induced with streptozotocin.At eight weeks after an intrasplenic injections (IS injection) of original STZ-RCC, this procedure yielded metastasic foci in the liver, which we transplanted serially in syngeneic mice (STZ-HM1). STZ-HM1 was then injected into the spleen of a syngeneic mouse, which provided a source for further cycles of hepatic metastasis selection. Three cycles of selection for hepatic metastasis yielded a high hepatic metastasis line (STZ-HM3). Intravenous injection of the parent line (original STZ-RCC) yielded metastatic foci in the lung eight weeks later, which we also transplanted serially in syngeneic mice (STZ-PM1).The repeated IS injection of the cells was clearly responsible for the increase in the frequency of hepatic metastasis and the number of its nodules. In particular, STZ-HM3 was revealed to have more metastatic nodules in the liver ranging from 293 to 432 (median; 368) in all five mice at eight weeks after IS injection. STZ-PM1 had a significantly higher rate of pulmonary metastasis and more pulmonary metastatic nodules after intravenous injection than the parent line. These results confirm that the parent line, STZ-RCC, has a heterogeneity in the metastatic phenotype.In vitro invasion assay for STZ-RCC, STZ-HM1, -HM2 and -HM3 demonstrated that in vitro invasive potential was paralleled with in vivo hepatic metastasis potential. The result suggests that the invasion potential revealed by in vitro invasion assay is important in metastasis formation.

10.5980/jpnjurol1989.82.1408

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Citations (3)

THE CLINICAL INVESTIGATION OF TUMOR MARKERS FOR RENAL CELL CARCINOMA

The Japanese Journal of Urology (1988)

Kiyohito Yamazaki Yoshiaki Kumamoto Taiji Tsukamoto K Ohmura Noriomi Miyao

37例の腎癌症例においてTPA, ferritin, ISSを測定し, これらの腎癌における腫瘍マーカーとしての意義につき検討した.TPAの平均値は stage Iでは正常範囲内 (正常上限値: 110U/L) であったが, stage II, III, IVにおいてはこれを上回っていた. また陽性率は stage II, 55.6%, stage III, IV 60%, であったが, stage Iでは12.5%と低かった.ferritin の平均値は stage I, IIでは正常範囲内 (正常上限値: 220ng/ml) であったが, stage III, IV はこれを上回っていた (283.4, 292.1ng/ml). また陽性率は stage I, 12.5%, stage II 0%, stage III 40%, stage IV 46.7%であった.ISSの正常上限値を500μg/mlとしたとき, ISSの各 stage の平均値はいずれもこれを上回っていた. またその陽性率はTPA, ferritin より高く, stage I 40%, II 57.1%, III 66.7%, IV 90.9%であった.これらのことより三者はいずれも腎癌の stage が進むにつれてその値, 陽性率は高くなる傾向を認めた.また, 治療の前後で三者を測定したところ, いずれも臨床経過とある程度相関しており, 腎癌のモニタリングに有用であると思われた.更に三者の combination assay により, 26例中24例 (92.3%) においてそのいずれかが陽性であったことより, この combination assay は意義のあることと考えられた.

10.5980/jpnjurol1928.79.1_28

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CLINICAL STUDY OF PENILE CANCER

The Japanese Journal of Urology (1990)

Noriomi Miyao Yoshiaki Kumamoto Taiji Tsukamoto K Ohmura Kiyohito Yamazaki

Recent progress in molecular biology suggests a certain relationship between penile cancer and human papilloma virus infection. However, the treatment for penile cancer has not been established since each institute has experienced only a small number of patients. We analyzed the result of our treatment for 14 penile cancer patients during past twenty years. Ten of the 14 patients were initialy treated for the primary lesion with a combination of peplomycin (PEP) or bleomycin (BLM) and radiation therapy. Of these, 9 were found not to have residual viable cancer cells in their primary lesions. No local recurrence was found in all 7 patients in whom the penis was preserved. This result suggests that combination of PEP (BLM) and radiation preserves the penis without increasing the risk of local recurrence.Penile cancer-related death did not occur in patients without lymph node metastasis. However, this cancer death did occur in 4 out of 7 patients with lymph node metastasis, suggesting that metastasis is one of the important prognostic factors. PEP (BLM) and radiation therapy with or without regional lymph node dissection did not improve the prognosis of patients with advanced penile carcinoma, such as with pN2, pN3 or distant metastasis. More effective management may be necessary for these patients.

Penile Carcinoma

10.5980/jpnjurol1989.81.1550

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THE STUDY OF PSP INDEX AND PSP<sub>60</sub> AS A NEW METHOD OF RENAL FUNCTION TEST WITHOUT URINE COLLECTION

The Japanese Journal of Urology (1972)

Seiji Furuya Takahiro Tamiya Yoshiaki Kumamoto

The PSP excretion test and clearance test are not suited to the assessment of renal function in a patient who has a dead space or fistula in the urinary tract or who is unable to cooperate with doctor, because in these cases accurate urine collection is impossible. Therefore, the renal function test without urine collection should be selected in such cases.The plasma phenolsulfonphthalein index (PSPI) or the sixty minutes plasma PSP concentration (PSP60) is a simple and clinically recommendable test among renal function tests without urine collection. These tests are calculated from the plasma PSP concentration following a single intravenous injection in a dosage of 1mg per kilogram of body weight.We clinically studied the reliability of both tests. The results are as follows.1) Normal range of PSPI is 12-24, and PSP60 is less than 100mcg/dl.2) The correlatin coefficient for PSPI with BUN, serum creatinine, Ccr, and CPAH are respectively 0.56, 0.58, 0.74, and 0.78. The correlation coefficient for PSP60 with BUN, serum creatinine, Ccr', and CPAH are respectively 0.82, 0.84, 0.76, and 0.77. It is certified from these data, that PSPI and PSP60 have high correlations with other clearance tests and are reliable indicators of the degree of renal function.3) In comparison of PSPI method that needs repeated blood samplings, PSP60 is enough with only two blood samplings. Moreover, a significant correlation between PSPI and PSP60 (r=0.82) is observed.We think that PSP60 is a very recommendable routine test of renal function in clinical work.

Urine collection device

10.5980/jpnjurol1928.63.8_626

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Citations (1)

Current Status of the Screening of Chlamydia trachomatis Infection Among Japanese Pregnant Women

Journal of Clinical Medicine Research (2015)

Shunji Suzuki Masanobu Tanaka Hideo Matsuda Yuki Tsukahara Yasushi Kuribayashi

Chlamydia trachomatis (CT) infection in pregnancy can cause maternal disease, adverse pregnancy outcomes, and neonatal disease [1-6]. In general, approximately 80% of CT infected women are asymptomatic or minimally symptomatic. There-fore, screening is the only means to effectively identify infec-tions [2]. In Japan, pregnant women are routinely tested for CT with the Japanese public funds. According to the guide-lines for obstetrical practice in Japan [7], Japanese obstetri-cians must provide a test for the detection of CT for the pre-vention of neonatal CT infection and diagnose urogenital CT infection when CT is detected using polymerase chain reac-tion (PCR), strand displacement amplification, transcription mediated amplification, an enzyme immunoassay, or culture methods in specimens obtained from the uterine cervix (CT nucleic acid detection tests). However, CT antibody detection by IgA tests has been substituted for these methods by some of obstetricians.On October 2014, we requested 2,544 obstetrical facilities that are members of Japan Association of Obstetricians and Gynecologists (JAOG) to provide information of CT screen-ing tests in pregnant women between October 2013 and March 2014. A total of 1,644 (64.6%) of 2,544 obstetrical facilities responded with possible statistical analysis information on a total of 328,788 women, accounting for approximately 65% of all deliveries that occurred in Japan during the study period. Of the 1,644 obstetrical facilities, CT nucleic acid detection PCR tests, CT nucleic acid detection tests except PCR and CT antibody detection tests were performed in 1,221 (74.3%), 408 (24.8%) and 15 (0.9%) facilities, respectively.Table 1 shows the maternal age distribution under the three CT screening tests (CT nucleic acid detection tests with and without PCR and CT antibody detection tests). There were no significant differences in the maternal age distribution among the three CT screening tests groups.Table 2 shows the results of CT screening tests (CT nucle-ic acid detection tests with and without PCR and CT antibody detection tests) of the study population by age. There were no significant differences in the rate of positive CT between the two groups of CT nucleic acid detection screening tests with and without PCR. However, the positive rate by the CT anti-body detection tests was significantly higher than those by the two CT nucleic acid detection tests with and without PCR (P < 0.01 by X

10.14740/jocmr2137w

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Citations (8)

Basic and clinical studies of tazobactam/piperacillin (TAZ/PIPC) in complicated urinary tract infections

Nihon Kagaku Ryōhō Gakkai zasshi/Nihon Kagaku Ryoho Gakkai zasshi (1994)

Naoki Itoh Takaoki Hirose Yoshiaki Kumamoto

Piperacillin/tazobactam

Tazobactam

Source

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Epidemiological and Bacteriological Study on Gonococcal Infections

Kansenshogaku zasshi (1992)

Masahiro Nishimura Yoshiaki Kumamoto Takaoki Hirose Mikio Koroku Midori Hojo

Epidemiological and bacteriological studies on Neisseria gonorrhoeae isolated in Sapporo, Japan, in 1980 and 1991 performed and the following results were obtained. 1. The range of age in the patients infected with Neisseria gonorrhoeae tended to be younger than those in the whole country. 2. Male patients in the early 20s or younger with gonococcal urethritis were often infected by bon-professional females but those in their late 20s or older were often infected from professional females, for example prostitutes and hostesses. 3. The rate of professional females who were positive to gonococci reached 17.4% and young females in their teens with cervicitis had the highest morbidity rate of gonococci than those in the older females. 4. The latent period in gonococcal infections tended to become longer gradually. 5. The isolation rate of penicillinase producing Neisseria gonorrhoeae (PPNG) showed a peak of 23.9% (61/255) in 1985, but gradually declined thereafter and it was 3.7% (1/27) in 1991. 6. An investigation on auxotype showed a decline of proto and Pro-strains and an increase of AHU-strains in non-PPNG. And most of the PPNG belonged to proto or Pro-strains. 7. With the relationship between auxotype and sensitivity to AMPC, AHU-strains were more sensitive than proto or Pro-strains.

Neisseria gonorrhoeae

Gonococcal infection

Cervicitis

Isolation

Neisseria

10.11150/kansenshogakuzasshi1970.66.743

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Citations (1)

Prevalence of female sexual dysfunction symptoms and its relationship to quality of life: A Japanese female cohort study

Urology (2005)

Shin‐ichi Hisasue Yoshiaki Kumamoto Yoshikazu Sato Naoya Masumori Hiroki Horita

Orgasm