Pedro Henrique Silveira Corrêa

Centro Universitário Serra dos Órgãos

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Regina Matsunaga Martin

Denison University

Berenice B. Mendonça

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

M O R Leite

Universidade de São Paulo

Edson L. Arioli

Universidade de São Paulo

A Borelli

Universidade de São Paulo

Bruno Ferraz‐de‐Souza

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Antônio C. Bianco

University of Chicago

Marília Martins Silveira Marone

Faculdade de Ciências Médicas da Santa Casa de São Paulo

Vanda Jorgetti

Universidade de São Paulo

Pedro R. Genta

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Cooperative Institutions

Universidade de São Paulo

Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Universidade Brasil

Hospital Universitário da Universidade de São Paulo

Instituto do Câncer do Estado de São Paulo

Universidade Federal de São Paulo

Hospital São Paulo

Hospital de Clínicas

Centro Universitário das Faculdades Metropolitanas Unidas

Universidade Cidade de São Paulo

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Unusual Clinical Presentation of Intrathyroidal Parathyroid Carcinoma

Mariana Tenorio Antunes Reis Berenice B. Mendonça Marcos Roberto de Menezes Vanessa Dalalio Fabio LM Montenegro

Parathyroid carcinoma

Presentation (obstetrics)

10.1210/endo-meetings.2011.part3.p19.p3-51

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Citations (1)

Avaliacao bioquimica e densitometrica da reposicao hormonal na pos-menopausa

Arquivos Brasileiros de Endocrinologia & Metabologia (1996)

D T O M Novo L Gallina Edson L. Arioli E N Genta J B Mechica

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Relato de caso: doença celíaca recém-diagnosticada como fator agravante de osteoporose em mulher idosa

Arquivos Brasileiros de Endocrinologia & Metabologia (2006)

Camila Corrêa Matias Pereira Pedro Henrique Silveira Corrêa Alfredo Halpern

Mulher de 63 anos procurou endocrinologista para seguimento de osteoporose. Densitometria óssea revelava T L1-L4= -3,5 DP [Densidade mineral óssea (DMO): 0,766 g/cm²] e Tcolo fêmur= -2,4 DP (DMO: 0,716 g/cm²). Em uso de cálcio e vitamina D há 2 anos. Hipotireoidismo há 5 anos em uso de levotiroxina. Introduzido alendronato 70 mg/semana com ganho significativo de massa óssea no primeiro ano (6,1%, igualmente em coluna e colo de fêmur). Após 5 anos de seguimento, paciente passou a apresentar emagrecimento, anemia e piora dos níveis densitométricos (perda de 12,6% em coluna lombar e 20,9% em colo de fêmur). Anamnese revelou quadro de diarréia intermitente há 2 anos, levando à suspeita de doença celíaca. Pesquisa de anticorpos anti-gliadina e anti-endomísio resultou positiva: 25,3 U/mL (< 20) e 1/5 U/mL (VR: negativo), respectivamente. Bioquímica óssea mostrava cálcio e fósforo normais, paratormônio aumentado: 283 pg/mL (10-65) e marcadores de reabsorção óssea aumentados, sugerindo hiperparatireoidismo secundário à síndrome mal-absortiva. Após 1 ano de dieta isenta de glúten, houve melhora dos sintomas mal-absortivos e importante aumento de DMO (47,3% em coluna lombar e 31,6% em colo de fêmur), reforçando o diagnóstico de doença celíaca como fator agravante de osteoporose nesta paciente.

10.1590/s0004-27302006000600022

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Diagnóstico de metastase do carcinoma diferenciado de tireóide: pesquisa de corpo inteiro vs. Tireoglobulina serica

Arquivos Brasileiros de Endocrinologia & Metabologia (1988)

Marília Martins Silveira Marone Pedro Henrique Silveira Corrêa Nilza Maria Scalissi Rui M. B. Maciel Antônio C. Bianco

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Predictors of Bone Mass Recovery Following Cure of Primary Hyperparathyroidism: 1-Year Follow-Up of 49 cases

Bruno Ferraz‐de‐Souza Regina Matsunaga Martin Manuela Giuliani Marcondes Rocha Adriana M. Fernandes Pedro Henrique Silveira Corrêa

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Improvement of adynamic bone disease after renal transplantation

Brazilian Journal of Medical and Biological Research (2006)

Kald Abdallah Vanda Jorgetti Renata Cristina de Campos Pereira Silveira Luciene M. dos Reis Luíz Miguel Pereira

Low bone remodeling and relatively low serum parathyroid hormone (PTH) levels characterize adynamic bone disease (ABD). The impact of renal transplantation (RT) on the course of ABD is unknown. We studied prospectively 13 patients with biopsy-proven ABD after RT. Bone histomorphometry and bone mineral density (BMD) measurements were performed in the 1st and 12th months after RT. Serum PTH, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and osteocalcin were measured regularly throughout the study. Serum PTH levels were slightly elevated at transplantation, normalized at the end of the third month and remained stable thereafter. Bone biopsies performed in the first month after RT revealed low bone turnover in all patients, with positive bone aluminum staining in 5. In the 12th month, second biopsies were performed on 12 patients. Bone histomorphometric dynamic parameters improved in 9 and were completely normalized in 6, whereas no bone mineralization was detected in 3 of these 12 patients. At 12 months post-RT, no bone aluminum was detected in any patient. We also found a decrease in lumbar BMD and an increase in femoral BMD. Patients suffering from ABD, even those with a reduction in PTH levels, may present partial or complete recovery of bone turnover after successful renal transplantation. However, it is not possible to positively identify the mechanisms responsible for the improvement. Identifying these mechanisms should lead to a better understanding of the physiopathology of ABD and to the development of more effective treatments.

Bone remodeling

Bone disease

Bone histomorphometry

10.1590/s0100-879x2006000100004

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Citations (16)

Tratamento cirúrgico do hiperparatireoidismo

Arquivos Brasileiros de Endocrinologia & Metabologia (2006)

Pedro Henrique Silveira Corrêa

10.1590/s0004-27302006000500001

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Bone quality and osteoporosis therapy

Arquivos Brasileiros de Endocrinologia & Metabologia (2010)

Regina Matsunaga Martin Pedro Henrique Silveira Corrêa

Although BMD measured by DXA is a useful clinical tool for osteoporosis diagnosis, changes resulting from osteoporosis treatment only partially explain the observed reduction in fractures. Several other bone properties that influence its resistance to fractures and explain this discrepancy have been defined as "bone quality". Bone quality is determined by its structural and material properties and orchestrated by bone turnover, a continuous process of renewal through which old or damaged bone is replaced by a mechanically healthy bone and calcium homeostasis is maintained. Bone structural properties include its geometry (size and shape) and microarchitecture (trabecular architecture and cortical porosity), while bone material properties include its mineral and collagen composition as well as microdamage and its repair. This review aims to update concepts surrounding bone quality and how drugs employed to treat osteoporosis might influence them.

Bone remodeling

Trabecular bone score

10.1590/s0004-27302010000200015

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Citations (58)

A novel GNAS mutation in an infant boy with pseudohypoparathyroidism type Ia and normal serum calcium and phosphate levels

Arquivos Brasileiros de Endocrinologia & Metabologia (2010)

Mariana Tenorio Antunes Reis Andreína Cattani Berenice B. Mendonça Pedro Henrique Silveira Corrêa Regina Matsunaga Martin

The objective of this study was to describe a new mutation in GNAS in a family with pseudohypoparathyroidism type Ia (PHP Ia), a rare osteometabolic disease. An 8-month-old boy was seen by an Endocrinologist due to obesity and low growth velocity. Noteworthy, his mother exhibited typical Albright hereditary osteodystrophy (AHO) phenotype. The clinical diagnosis of PHP Ia was suspected. The GNAS coding region from mother and son was amplified and directly sequenced. A novel heterozygous missense mutation (c.673T>C) was identified in exon 5 in both patients. In this family, the mother's clinical picture was the clue for the son's diagnosis. Molecular analysis of GNAS confirmed the diagnosis of PHP Ia in both patients and the child's early diagnosis was possible. Moreover, this novel missense substitution expands the spectrum of GNAS mutations associated with this disorder and allows for genetic counseling of this family.

GNAS complex locus

Pseudohypoparathyroidism

Osteodystrophy

10.1590/s0004-27302010000800011

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Mutação na subunidade alfa da proteína G em paciente com heteroplasia óssea hereditária e estigmas da osteodistrofia de Albright

Arquivos Brasileiros de Endocrinologia & Metabologia (2007)

R M Alvarez-San Martin Lara Bußmann Ana Cláudia Latronico Berenice B. Mendonça Pedro Henrique Silveira Corrêa

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