Wei-Chuan Chen

National Synchrotron Radiation Research Center

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Trends

Author Order

Document Type

Co-Authors

Chih‐Hwa Chen

Taipei Medical University

Cheng-Maw Cheng

National Synchrotron Radiation Research Center

Ku-Ding Tsuei

National Synchrotron Radiation Research Center

Yu‐Pin Chen

Taipei Medical University

Tay‐Rong Chang

National Cheng Kung University

Horng‐Tay Jeng

National Tsing Hua University

Jo‐Shu Chang

Tunghai University

Shih-Chang Weng

National Synchrotron Radiation Research Center

Shu Hsuan Su

National Cheng Kung University

Yu-Hong Wei

Yuan Ze University

Cooperative Institutions

National Cheng Kung University

National Taiwan University

National Yang Ming Chiao Tung University

Taipei Medical University

National Tsing Hua University

National Synchrotron Radiation Research Center

Taipei Medical University Hospital

Yuan Ze University

National Sun Yat-sen University

Wan Fang Hospital

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

Risk factors for hyperbilirubinemia in breastfed term neonates

European Journal of Pediatrics (2011)

Ying-Juang Chen Wei-Chuan Chen Chung‐Ming Chen

Apgar score

Outpatient clinic

10.1007/s00431-011-1512-8

Cite

Citations (28)

Effect of 17β-Estradiol on Intracellular Ca<sup>2+</sup> Levels in Renal Tubular Cells

Pharmacology (2002)

Wei-Chuan Chen Jin-Shiung Cheng Kang-Ju Chou Kwong-Yui Tang Jong-Khing Huang

The effect of 17beta-estradiol on intracellular Ca(2+) concentrations ([Ca(2+)](i)) in Madin Darby canine kidney cells was investigated by using the fluorescent dye fura-2. 17Beta-estradiol (5-100 micromol/l) induced instantaneous increases in [Ca(2+)](i) in a concentration-dependent manner. Ca(2+) removal inhibited 45 +/- 15% of the Ca(2+) signal. In Ca(2+)-free medium, pretreatment with 50 micromol/l 17beta-estradiol abolished the [Ca(2+)](i) increases induced by 2 micromol/l carbonylcyanide m-chlorophenylhydrazone (CCCP; a mitochondrial uncoupler), 1 micromol/l thapsigargin (an endoplasmic reticulum Ca(2+) pump inhibitor) and 50 micromol/l brefeldin A (an antibiotic which disperses the Golgi complex), but pretreatment with brefeldin A, CCCP and thapsigargin only partly inhibited the 17beta-estradiol-induced [Ca(2+)](i) signal. Adding 3 mmol/l Ca(2+) increased [Ca(2+)](i) in cells pretreated with 5-100 micromol/l 17beta-estradiol in Ca(2+)-free medium. Pretreatment with 1 micromol/l U73122 to abolish the formation of inositol-1,4,5-trisphosphate inhibited 50% of the Ca(2+) release induced by 50 micromol/l 17beta-estradiol. 17Beta-estradiol (20 micromol/l) also increased [Ca(2+)](i) in human bladder cancer cells and prostate cancer cells. Collectively, this study shows that 17beta-estradiol evoked a significant internal Ca(2+) release and external Ca(2+) entry possibly in a nongenomic manner.

Thapsigargin

Brefeldin A

Fura-2

10.1159/000056155

Cite

Citations (8)

Intermittent Parathyroid Hormone Injection Can Decrease Femoral Head Collapse in the Vascular Deprivation of Rat Femoral Head Model

Indian Journal of Orthopaedics (2019)

Chih-Wei Chiang Wei-Chuan Chen Chian-Her Lee Chih‐Hwa Chen

10.4103/ortho.ijortho_315_17

Cite

Citations (1)

MAPK phosphatase-1 contributes to trichostatin A inhibition of cyclooxygenase-2 expression in human umbilical vascular endothelial cells exposed to lipopolysaccharide

Biochimica et Biophysica Acta (BBA) - General Subjects (2011)

Ya-Fen Hsu Joen‐Rong Sheu Chien‐Huang Lin Wei-Chuan Chen George Hsiao

Trichostatin A

Proinflammatory cytokine

10.1016/j.bbagen.2011.08.015

Cite

Citations (23)

Effectiveness of Strontium Ranelate in the Treatment of Rat Model of Legg–Calve–Perthes Disease

Indian Journal of Orthopaedics (2018)

Yu‐Pin Chen Amyla Tan Wei‐Pin Ho Tai-Yuan Chuang Wei-Chuan Chen

Strontium ranelate

Legg-Calve-Perthes disease

10.4103/ortho.ijortho_437_16

Cite

Citations (6)

Topological Proximity-Induced Dirac Fermion in Two-Dimensional Antimonene

ACS Nano (2021)

Shu Hsuan Su Pei-Yu Chuang Hsin-Yu Chen Shih-Chang Weng Wei-Chuan Chen

Antimonene is a promising two-dimensional (2D) material that is calculated to have a significant fundamental bandgap usable for advanced applications such as field-effect transistors, photoelectric devices, and the quantum-spin Hall (QSH) state. Herein, we demonstrate a phenomenon termed topological proximity effect, which occurs between a 2D material and a three-dimensional (3D) topological insulator (TI). We provide strong evidence derived from hydrogen etching on Sb2Te3 that large-area and well-ordered antimonene presents a 2D topological state. Delicate analysis with a scanning tunneling microscope of the evolutionary intermediates reveals that hydrogen etching on Sb2Te3 resulted in the formation of a large area of antimonene with a buckled structure. A topological state formed in the antimonene/Sb2Te3 heterostructure was confirmed with angle-resolved photoemission spectra and density-functional theory calculations; in particular, the Dirac point was located almost at the Fermi level. The results reveal that Dirac fermions are indeed realized at the interface of a 2D normal insulator (NI) and a 3D TI as a result of strong hybridization between antimonene and Sb2Te3. Our work demonstrates that the position of the Dirac point and the shape of the Dirac surface state can be tuned by varying the energy position of the NI valence band, which modifies the direction of the spin texture of Sb-BL/Sb2Te3 via varying the Fermi level. This topological phase in 2D-material engineering has generated a paradigm in that the topological proximity effect at the NI/TI interface has been realized, which demonstrates a way to create QSH systems in 2D-material TI heterostructures.

Topological insulator

Surface States

10.1021/acsnano.1c05454

Cite

Citations (10)

Selective Hydrogen Etching Leads to 2D Bi(111) Bilayers on Bi₂Se₃: Large Rashba Splitting in Topological Insulator Heterostructure

Chemistry of Materials (2017)

Shu Hsuan Su Pei Yu Chuang Sheng Wen Chen Hsin Yu Chen Yi Tung

Ultrathin bilayers (BLs) of bismuth have been predicated to be a two-dimensional (2D) topological insulator. Here we report on a new route to manufacture the high-quality Bi bilayers from a 3D topological insulator, a top-down approach to prepare large-area and well-ordered Bi(111) BL with deliberate hydrogen etching on epitaxial Bi2Se3 films. With scanning tunneling microscopy (STM) and X-ray photoelectron spectra (XPS) in situ, we confirm that the removal of Se from the top of a quintuple layer (QL) is the key factor, leading to a uniform formation of Bi(111) BL in the van der Waals gap between the first and second QL of Bi2Se3. The angle resolved photoemission spectroscopy (ARPES) in situ and complementary density functional theory (DFT) calculations show a giant Rashba splitting with a coupling constant of 4.5 eV Å in the Bi(111) BL on Bi2Se3. Moreover, the thickness of Bi BLs can be tuned by the amount of hydrogen exposure. Our ARPES and DFT study indicated that the Bi hole-like bands increase with increasing the Bi BL thickness. The selective hydrogen etching is a promising route to produce a uniform ultrathin 2D topological insulator (TI) that is useful for fundamental investigations and applications in spintronics and valleytronics.

Topological insulator

10.1021/acs.chemmater.7b01908

Cite

Citations (17)

Enhancing production of lutein by a mixotrophic cultivation system using microalga Scenedesmus obliquus CWL-1

Bioresource Technology (2019)

Wei-Chuan Chen Yin-Che Hsu Jo‐Shu Chang Shih‐Hsin Ho Li-Fen Wang

Mixotroph

Scenedesmus

10.1016/j.biortech.2019.121891

Cite

Citations (47)