François Paquet

Institut de Radioprotection et de Sûreté Nucléaire

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Elie Tourlonias

Institut de Radioprotection et de Sûreté Nucléaire

P. Houpert

Institut de Radioprotection et de Sûreté Nucléaire

Jean‐Marc Bertho

Institut de Radioprotection et de Sûreté Nucléaire

Sandrine Frelon

Institut de Radioprotection et de Sûreté Nucléaire

Isabelle Dublineau

Institut de Radioprotection et de Sûreté Nucléaire

Johanna Frick

University of Fribourg

Marjorie Monleau

Centre National de la Recherche Scientifique

Olivia Delissen

Institut de Radioprotection et de Sûreté Nucléaire

P. Gourmelon

Institut de Radioprotection et de Sûreté Nucléaire

V. Chazel

Institut de Radioprotection et de Sûreté Nucléaire

Cooperative Institutions

Institut de Radioprotection et de Sûreté Nucléaire

Inserm

Centre National de la Recherche Scientifique

CEA Paris-Saclay - Etablissement de Fontenay-aux-roses

Service de la Santé Publique

Sorbonne Université

Nantes Université

Commissariat à l'Énergie Atomique et aux Énergies Alternatives

Centre de Recherche Saint-Antoine

Hôpital Saint-Antoine

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Occupational intakes of radionuclides

C. H. Clement N Hamada François Paquet

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Citations (14)

Heterogeneous accumulation of uranium in the brain of rats

Radiation Protection Dosimetry (2007)

P. Houpert Sandrine Frelon Marjorie Monleau Cyrill Bussy V. Chazel

Recent reports suggest that uranium can accumulate not only in known target organs, that is, kidneys or bones, but also in others such as central nervous system. In the present work, the accumulation of uranium in the brain of rats was studied after repeated exposure by inhalation, chronic exposure by ingestion and acute exposure by injection. For each route of administration, the amount of uranium entering the brain was low. The results showed different accumulation in the brain areas according to the route of intake. Injection gave a rather homogeneous distribution in the different brain areas, whereas both inhalation and ingestion yielded heterogeneous but specific accumulation. These differences in distribution suggest the operation of different mechanisms of delivery of uranium to the brain tissues.

Depleted Uranium

Inhalation exposure

10.1093/rpd/ncm255

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Citations (33)

Brain accumulation of inhaled uranium in the rat depends on aerosol concentration, exposure repetitions, particle size and solubility

Toxicology Letters (2021)

Benjamin B. Tournier Chrystelle Ibanez Elie Tourlonias Fabrice Petitot François Paquet

Inhalation exposure

Acute exposure

10.1016/j.toxlet.2021.08.002

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Citations (6)

L'ICP-MS: Un outil pour le suivi des contaminations internes à l'uranium

HAL (Le Centre pour la Communication Scientifique Directe) (2005)

Sandrine Frelon Marjorie Monleau Elie Tourlonias Olivia Delissen V. Chazel

Inductively coupled plasma mass spectrometry (ICP-MS) is considered as a very convenient technique for radionuclide measurement in the nuclear field owing to its high sensitivity and accuracy and to the possibility measuring a large range of masses. To study the different biokinetic behaviours of two different uranium oxides, insoluble UO2 and soluble UO4' in rats after successive inhalations, an analytical procedure to measure the quantity of uranium coming from each oxide was developed. The number of biological matrices studied was limited to three: two ways of the airborne uranium entry, i.e. the set lung/trachea and the gastrointestinal tract, and one way of excretion with urines. After repeated inhalations of UO2 followed by one acute inhalation of UO4' total uranium measurement in the different matrices was performed either with a kinetic phosphorescence analyzer (KPA), ICP-MS or with α- spectrometry. In addition, the amount of uranium coming from UO4' UO2 or natural uranium, respectively, was calculated by ICP-MS and α-spectrometry. All the results were compared and found to be similar. As a conclusion, the analytical procedure developed with ICP-MS was validated and ICP-MS was confirmed to be an efficient tool for the study of successive internal contaminations with uranium.

Depleted Uranium

Uranium oxide

Natural uranium

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Biodistribution of 137Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system

Radiation and Environmental Biophysics (2010)

Jean‐Marc Bertho Sonia Louiba Marie-Cécile Faure Elie Tourlonias Johanna Frick

Biodistribution

10.1007/s00411-010-0267-3

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Citations (19)

ACCUMULATION AND DISTRIBUTION OF URANIUM IN RATS AFTER CHRONIC EXPOSURE BY INGESTION

Health Physics (2006)

François Paquet P. Houpert E Blanchardon Olivia Delissen Christophe Maubert

Data describing the biokinetics of radionuclides after contamination come mainly from experimental acute exposures of laboratory animals and follow-up of incidental exposures of humans. These data were compiled to form reference models that could be used for dose calculation in humans. In case of protracted exposure, the same models are applied, assuming that they are not modified by the duration of exposure. This work aims at testing this hypothesis. It presents new experimental data on retention of uranium after chronic intake, which are compared to values calculated from a biokinetic model that is based on experiments of acute exposure of rats to uranium. Experiments were performed with 56 male Sprague Dawley rats, from which 35 were exposed during their whole adult life to 40 mg L of uranyl nitrate dissolved in mineral water and 21 were kept as controls. Animals were euthanatized at 32, 95, 186, 312, 368, and 570 d after the beginning of contamination. Urine and all tissues were removed, weighted, mineralized, and then analyzed for uranium content by Kinetics Phosphorescence Analysis (KPA) or by ICP-MS. Experimental data showed that uranium accumulated in most organs, following a nonmonotonous pattern. Peaks of activities were observed at 1-3, 10, and 19 mo after the beginning of exposure. Additionally, accumulation was shown to occur in tissues such as teeth and brain that are not usually described as target organs. Comparison with model prediction showed that the accumulation of uranium in target organs after chronic exposure is overestimated by the use of a model designed for acute exposure. These differences indicate that protracted exposure to uranium may induce changes in biokinetic parameters when compared to acute contamination and that calculation of dose resulting from chronic intake of radionuclides may need specific models that are not currently available.

Uranyl nitrate

10.1097/01.hp.0000174527.66111.83

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Citations (85)

DISTRIBUTION OF 137CS IN RAT TISSUES AFTER VARIOUS SCHEDULES OF CHRONIC INGESTION

Health Physics (2010)

Elie Tourlonias Jean‐Marc Bertho R. Gurriarán Philippe Voisin François Paquet

The aim of this work was to compare the distribution of 137Cs in organisms after chronic ingestion following different schedules. Rats were contaminated through drinking water containing 6,500 Bq L(-1) of 137Cs, starting either at birth, at weaning, or upon reaching adult age (13 wk). Animals were then sacrificed after different durations of ingestion. 137Cs content of organs and excreta were determined by gamma counting. A slight decrease in 137Cs elimination through urine was observed according to the age of animals. All organs tested showed similar 137Cs content, with the exception of striated muscles and the thyroid at certain ages, which showed the highest accumulation of 137Cs. The lowest 137Cs concentration was found in the blood, which acts as a transfer compartment after absorption in the intestine. Substructures of the central nervous system showed a homogeneous level of 137Cs accumulation, except for the olfactive bulbs. In these structures, an increased concentration of 137Cs was observed, suggesting a possible direct route of intake through the nasal epithelium. Overall, these results are in agreement with current models for the biokinetics of 137Cs. However, these results also suggest that the thyroid should be taken into account in future models of 137Cs biokinetics.

10.1097/hp.0b013e3181d4f00e

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Citations (13)

Evaluation of the effect of chronic exposure to 137Cesium on sleep–wake cycle in rats

Toxicology (2006)

P. Lestaevel B. Dhieux Elie Tourlonias P. Houpert François Paquet

10.1016/j.tox.2006.06.003

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Citations (15)

Experimental Determination of the Solubility of Industrial UF4 Particles

Radiation Protection Dosimetry (2000)

V. Chazel P. Houpert François Paquet É. Ansoborlo Michael Napoli

Journal Article Experimental Determination of the Solubility of Industrial UF4 Particles Get access V. Chazel, V. Chazel Search for other works by this author on: Oxford Academic PubMed Google Scholar P. Houpert, P. Houpert Search for other works by this author on: Oxford Academic PubMed Google Scholar F. Paquet, F. Paquet Search for other works by this author on: Oxford Academic PubMed Google Scholar E. Ansoborlo, E. Ansoborlo Search for other works by this author on: Oxford Academic PubMed Google Scholar M.H. Hengé-Napoli M.H. Hengé-Napoli Search for other works by this author on: Oxford Academic PubMed Google Scholar Radiation Protection Dosimetry, Volume 92, Issue 4, 1 December 2000, Pages 289–294, https://doi.org/10.1093/oxfordjournals.rpd.a033294 Published: 01 December 2000

10.1093/oxfordjournals.rpd.a033294

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Citations (8)

Chemical behaviour of three radionuclides (cesium, americium and technetium) and their uptake at the cytosolic level in aquatic organisms.

PubMed (1994)

Durand Jp Milcent Mc F. Goudard François Paquet Pierre Germain

In previous papers, we observed that there were great differences in the subcellular accumulation and elimination of 137Cs, 99Tc and 241Am in different marine animals. In this study, we analysed and compared the behaviour of these radionuclides at the cytosolic level. We found great similarities in the cytosolic distribution of a given radionuclide in the various organisms studied. The chemical characteristics of the radionuclides seem to play a major role in the biochemical affinity and metabolic behaviour in different aquatic organisms.

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Citations (3)