Yu Xiong

Second Affiliated Hospital of Fujian Medical University

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Feng Zheng

Second Affiliated Hospital of Fujian Medical University

Weipeng Hu

Peking University

Zhigang Pan

Second Affiliated Hospital of Fujian Medical University

Xinyue Huang

University of Electronic Science and Technology of China

Xiumei Guo

Second Affiliated Hospital of Fujian Medical University

C. Chen

China University of Geosciences

Hanlin Zheng

Anhui Medical University

Xiaodong Kang

Fujian Medical University

Chuhan Ke

Second Affiliated Hospital of Fujian Medical University

Pantelis Stavrinou

University Hospital Cologne

Cooperative Institutions

Fujian Medical University

Second Affiliated Hospital of Fujian Medical University

Affiliated Hospital of Southwest Medical University

Shandong University of Traditional Chinese Medicine

Southwest Medical University

Central South University

Weatherford College

Shanghai Jiao Tong University

Sichuan University

Guangdong Medical College

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Follow-up Neutrophil–Lymphocyte Ratio as a Predictor for Postoperative Pneumonia After Endovascular Treatment in Aneurysmal Subarachnoid Hemorrhage Patients: A Retrospective Analysis

Research Square (Research Square) (2023)

Xinyue Huang Xiumei Guo Wen Gao Liming Guo Yu Xiong

Abstract The association between NLR and postoperative pneumonia (POP) in patients with aneurysmal subarachnoid hemorrhage (aSAH) who underwent endovascular treatment remains poorly understood. Patients with aSAH who underwent endovascular treatment between January 2019 and April 2023 were included. The follow-up endpoint was the presence of POP at 30 days postoperatively. Logistic regression analysis was conducted using POP as the dependent variable. NLR was calculated at admission (NLR1), 24 h after endovascular treatment (NLR2), and 3–7 days after endovascular treatment (NLR3). Four prediction models were constructed: Model 1 (variables with p < 0.05, except for the NLR); Model 2 (Model 1 plus NLR1); Model 3 (Model 1 plus NLR2); and Model 4 (Model 1 plus NLR3). Among the 154 patients with aSAH, POP occurred in 101 (65.6%) patients. Higher NLRs at admission (odds ratio [OR] = 1.08; 95% Confidence Interval [CI] 1.02, 1.16; p = 0.019), 24 h postoperatively (OR = 1.14; 95% CI 1.05, 1.25; p = 0.005) and 3-7days postoperatively (OR = 1.17; 95% CI 1.02, 1.38; p = 0.04) were independently associated with the occurrence of POP. Follow-up NLR may be an independent predictor of POP in aSAH patients treated endovascularly. Elevated NLR at admission, 24 h postoperatively and 3–7 days postoperatively correlated with a high risk for POP.

Clinical endpoint

10.21203/rs.3.rs-3659638/v1

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The NLRP3 inflammasome is involved in resident intruder paradigm-induced aggressive behaviors in mice

Frontiers in Pharmacology (2023)

Qingying Yu Molin Liu Weibo Dai Yu Xiong Xiangyu Mu

Background: Aggressive behaviors are one of the most important negative behaviors that seriously endangers human health. Also, the central para-inflammation of microglia triggered by stress can affect neurological function, plasticity, and behavior. NLRP3 integrates stress-related signals and is a key driver of this neural para-inflammation. However, it is unclear whether the NLRP3 inflammasome is implicated in the development of aggressive behaviors. Methods: First, aggressive behavior model mice were established using the resident intruder paradigm. Then, aggressive behaviors were determined with open-field tests (OFT), elevated plus-maze (EPM), and aggressive behavior tests (AT). Moreover, the expression of P2X7R and NLRP3 inflammasome complexes were assessed by immunofluorescence and Western blot. The levels of NLRP3 and inflammatory cytokines were evaluated using enzyme-linked immunosorbent assay (ELISA) kits. Finally, nerve plasticity damage was observed by immunofluorescence, transmission electron microscope, and BrdU staining. Results: Overall, the resident intruder paradigm induced aggressive behaviors, activated the hippocampal P2X7R and NLRP3 inflammasome, and promoted the release of proinflammatory cytokines IL-1β in mice. Moreover, NLRP3 knockdown, administration of P2X7R antagonist (A804598), and IL-1β blocker (IL-1Ra) prevented NLRP3 inflammasome-driven inflammatory responses and ameliorated resident intruder paradigm-induced aggressive behaviors. Also, the resident intruder paradigm promoted the activation of mouse microglia, damaging synapses in the hippocampus, and suppressing hippocampal regeneration in mice. Besides, NLRP3 knockdown, administration of A804598, and IL-1Ra inhibited the activation of microglia, improved synaptic damage, and restored hippocampal regeneration. Conclusion: The NLRP3 inflammasome-driven inflammatory response contributed to resident intruder paradigm-induced aggressive behavior, which might be related to neuroplasticity. Therefore, the NLRP3 inflammasome can be a potential target to treat aggressive behavior-related mental illnesses.

Proinflammatory cytokine

10.3389/fphar.2023.974905

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Therapy with of RCHOP-14 Versus RCHOP-21 for People With Aggressive or Advanced Stage Indolent B-Cell Non-Hodgkins Lymphoma: A Systematic Review and Meta-Analysis

Research Square (Research Square) (2020)

Yue He Wenqiang Tao Dexiang Ji Wei Lu Yu Xiong

Abstract Background : With the advent of rituximab, RCHOP is considered the appropriate chemotherapy for aggressive or advanced stage indolent B-cell Non-Hodgkins Lymphoma(NHL). RCHOP-14 seems to achieve better outcomes than RCHOP -21 in aggressive or advanced stage indolent B-cell NHL patients in recent years. Methods : To verify the befitting chemotherapy regimens for B-cell NHL patients, we searched the electronic databases for relevant English-language literature published through January 2020. The primary outcomes were complete response(CR),progression-free survival (PFS), overall survival(OS), and Adverse events (AEs). Six eligible Phase II and III clinical randomized controlled trials (RCTs) and two high-quality observational comparative studies (OCSs)were extracted, and 5565 B-cell NHL patients involved in evaluable. Results : The analysis demonstrated no significant difference for CR rate (OR= 0.98,95%CI 0.77-1.24，P=0.85)between RCHOP-14 and RCHOP-21. Compared with RCHOP-21, the merged hazard ratio (HR) for PFS and OS was, respectively, 0.94 (95% CI: 0.84-1.06, P=0.32) and 0.91(95% CI: 0.83-1.01, P= 0.08) after treatment with RCHOP-14.A subgroup analysis based on the international prognostic index(IPI) score showed that both chemotherapy regimens were applicable in B-cell NHL patients with different prognosis. The frequency of toxic side-effects was similar between schemes. Conclusions : Therefore, the data presented suggest that the efficacy and safety of both regimens are comparable and that R-CHOP14 remains a viable plan in B-cell NHL patients who prefer a shorter therapy course.

10.21203/rs.3.rs-103091/v1

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Effect of magnesium sulfate on cerebral vasospasm in the treatment of aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis

Frontiers in Neurology (2023)

Hanlin Zheng Xiumei Guo Xinyue Huang Yu Xiong Wen Gao

The use of magnesium sulfate for treating aneurysmal subarachnoid hemorrhage (aSAH) has shown inconsistent results across studies. To assess the impact of magnesium sulfate on outcomes after aSAH, we conducted a systematic review and meta-analysis of relevant randomized controlled trials.PubMed, Embase, and the Cochrane Library were searched for relevant literature on magnesium sulfate for aSAH from database inception to March 20, 2023. The primary outcome was cerebral vasospasm (CV), and secondary outcomes included delayed cerebral ischemia (DCI), secondary cerebral infarction, rebleeding, neurological dysfunction, and mortality.Of the 558 identified studies, 16 comprising 3,503 patients were eligible and included in the analysis. Compared with control groups (saline or standard treatment), significant differences were reported in outcomes of CV [odds ratio (OR) = 0.61, p = 0.04, 95% confidence interval (CI) (0.37-0.99)], DCI [OR = 0.57, p = 0.01, 95% CI (0.37-0.88)], secondary cerebral infarction [OR = 0.49, p = 0.01, 95% CI (0.27-0.87)] and neurological dysfunction [OR = 0.55, p = 0.04, 95% CI (0.32-0.96)] after magnesium sulfate administration, with no significant differences detected in mortality [OR = 0.92, p = 0.47, 95% CI (0.73-1.15)] and rebleeding [OR = 0.68, p = 0.55, 95% CI (0.19-2.40)] between the two groups.The superiority of magnesium sulfate over standard treatments for CV, DCI, secondary cerebral infarction, and neurological dysfunction in patients with aSAH was demonstrated. Further randomized trials are warranted to validate these findings with increased sample sizes.

Cerebral Vasospasm

10.3389/fneur.2023.1249369

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Transradial versus transfemoral access for endovascular therapy of intracranial aneurysms: a systematic review and meta-analysis of cohort studies

Neurosurgical Review (2022)

Xinyue Huang Yu Xiong Xiumei Guo Xiaodong Kang C. Chen

Stroke

10.1007/s10143-022-01868-3

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Special-form radial collateral artery perforator flaps for the reconstruction of complex hand defects

Journal of Orthopaedic Surgery and Research (2024)

Yu Xiong Qin Xiong Liming Qing Panfeng Wu Juyu Tang

Abstract Background The reconstruction of complex wounds of the hand still has challenges in achieving aesthetic, functional and sensory recovery. We presented our experience of using the polyfoliate and chimeric radial collateral artery perforator flaps (RCAPF) to repair complex hand defects, aiming to explore the feasibility of special-form RCAPFs in hand coverage and enhance the comprehension of their respective indications. Methods From June 2014 to March 2021, 26 cases (19 males and 7 females, mean 44.4 years) underwent defect and sensation reconstruction of their hands with special-form RCAPFs, which manifested as multiple adjacent or irregular single wounds and composite tissue defects complicated with a degree of nerve injury. The clinical effects of the free RCAPFs were evaluated by integrating the postoperative and long-term follow-up outcomes of all cases. Results Altogether 8 polyfoliate flaps, 17 chimeric flaps and 1 polyfoliate-chimeric flap were harvested. Of them, 23 flaps survived uneventfully in one stage. Venous congestion occurred in 3 cases, two of which survived through vascular exploration and another one was finally repaired by the contralateral RCAPF. The follow-up results showed that the appearance of both the recipient and donor sites mostly recovered satisfactory. All the bone flaps properly healed. The BMRC sensory evaluation results of all skin flaps were S4 in 8 flaps, S3 in 18 flaps, and S2 in 9 flaps. Conclusions The free RCAPFs can be designed in various forms with a reliable blood supply, contributing to reconstructing simple and multiple wounds of the hand with or without bone defects and dead space.

Perforator flaps

Blood supply

10.1186/s13018-024-05024-z

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FERMT1 suppression induces anti-tumor effects and reduces stemness in glioma cancer cells

Journal of Cancer Research and Clinical Oncology (2024)

Zhigang Pan Chuhan Ke Hanlin Zheng Xiumei Guo Wen Gao

Abstract Objective Glioma is a leading cause of mortality worldwide, its recurrence poses a major challenge in achieving effective treatment outcomes. Cancer stem cells (CSCs) have emerged as key contributors to tumor relapse and chemotherapy resistance, making them attractive targets for glioma cancer therapy. This study investigated the potential of FERMT1 as a prognostic biomarker and its role in regulating stemness through cell cycle in glioma. Methods Using data from TCGA-GBM, GSE4290, GSE50161 and GSE147352 for analysis of FERMT1 expression in glioma tissues. Then, the effects of FERMT1 knockdown on cell cycle, proliferation, sphere formation ability, invasion and migration were investigated. The influences of FERMT1 on expression of glycolysis-related proteins and levels of ATP, glucose, lactate and G6PDH were also explored. Furthermore, the effects of FERMT1 knockdown on cellular metabolism were evidenced. Results Significant upregulation of FERMT1 in glioma tissues was observed. Silencing FERMT1 not only affected the cell cycle but also led to a notable reduction in proliferation, invasion and migration. The expression of glycolysis-associated proteins including GLUT1, GLUT3, GLUT4, and SCO2 were reduced by FERMT1 knockdown, resulted in increased ATP and glucose as well as decreased lactic acid and G6PDH levels. FERMT1 knockdown also inhibited cellular metabolism. Moreover, FERMT1 knockdown significantly reduced sphere diameter, along with inhibiting the expression of transcription factors associated with stemness in glioma cells. Conclusion These findings demonstrated that FERMT1 could be an ideal target for the advancement of innovative strategies against glioma treatment via modulating cellular process involved in stemness regulation and metabolism.

10.1007/s00432-024-05859-3

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Efficacy and safety of stem cells in the treatment of ischemic stroke: A meta-analysis

Medicine (2024)

Yu Xiong Xiumei Guo Wen Gao Chuhan Ke Xinyue Huang

Background: Stem cell therapy on ischemic stroke has long been studied using animal experiments. The efficacy and safety of this treatment in ischemic stroke patients remain uncertain. Methods: We searched for all clinical randomized controlled trials published before October 2023, on PubMed, EMBASE, and the Cochrane Library using predetermined search terms, and performed a meta-analysis of the efficacy of stem cell therapy in ischemic stroke patients. Results: 13 studies that included 592 ischemic stroke patients were reviewed. The mRS (MD −0.32, 95% CI −0.64 to 0.00, I 2 = 63%, P = .05), NIHSS (MD −1.63, 95% CI −2.69 to −0.57, I 2 = 58%, P = .003), and BI (MD 14.22, 95% CI 3.95–24.48, I 2 = 43%, P = .007) showed effective stem cell therapy. The mortality (OR 0.42, 95% CI 0.23–0.79, I 2 = 0%, P = .007) showed improved prognosis and reduce mortality with stem cell therapy. Conclusion: Stem cell therapy reduces mortality and improves the neurological prognosis of ischemic stroke patients. However, due to the different types of stem cells used and the limited data in the reported studies, the safety of clinical applications of stem cells in patients with ischemic stroke must be carefully evaluated. Future randomized controlled trials with large sample sizes from controlled cell sources are warranted to validate this finding.

Stem Cell Therapy

Stroke

10.1097/md.0000000000037414

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Citations (2)

Anterior cervical discectomy and fusion for the treatment of giant cervical disc herniation

Journal of Orthopaedic Surgery and Research (2023)

Weibin Liang Yu Xiong Yukun Jia Shaoqiang Li Kaishuai Zhao

Abstract Objective Giant cervical disc herniation (GCDH) was defined as a herniated intervertebral disc that accounted for more than 50% of the spinal canal. The purpose of this study was to analyse the feasibility of anterior cervical discectomy and fusion (ACDF) for the treatment of GCDH. Methods Patient demographic and imaging data, clinical results, and perioperative complications were analysed retrospectively. Results A total of 23 patients were included in the study. Spinal cord recovery pulsation was observed under a microscope in all cases. Postoperative magnetic resonance imaging showed complete decompression of the spinal cord and no residual intervertebral disc. The patients were followed up for 12 to 18 months. The average visual analogue scale score and Neck Disability Index decreased from 8.6 ± 0.5 and 86.0 ± 2.7% to 2.2 ± 0.2 and 26.7 ± 2.0%, respectively, three days after surgery. The average Japanese Orthopedic Association score increased from 6.9 ± 2.1 to 13.9 ± 1.1. The cervical spinal cord function improvement rate was 69.3%. No neurological complications after surgery were observed. Conclusion This study shows that ACDF is feasible for the treatment of GCDH disease. The results indicate that this approach can be used to safely remove herniated disc fragments, effectively relieve compression of the spinal cord, and improve neurological function.

Discectomy

Spinal decompression

Spinal cord compression

Intervertebral Disc

10.1186/s13018-023-04036-5

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Citations (1)

Verbascoside attenuates acute inflammatory injury in experimental cerebral hemorrhage by suppressing TLR4

Biochemical and Biophysical Research Communications (2019)

Xue Lai Yu Xiong Jie Zhou Fan Yang Jianhua Peng

Stroke

Verbascoside

Inflammatory response

10.1016/j.bbrc.2019.09.057

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Citations (22)