Kohei Fukumoto

Saiseikai Suita Hospital

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Toshikazu Yoshikawa

Kyoto Prefectural University of Medicine

Tomohisa Takagi

Kyoto Prefectural University of Medicine

Ken Inoue

Kyoto Prefectural University of Medicine

Yuji Naito

Shizuoka Medical Center

Osamu Handa

Kawasaki Medical School

Naohisa Yoshida

Kyoto Prefectural University of Medicine

Satoshi Kokura

Kyoto Prefectural University of Medicine

Akihito Harusato

Kyoto Prefectural University of Medicine

Kazuhiko Uchiyama

Kyoto Prefectural University of Medicine

Nobuaki Yagi

Asahi University

Cooperative Institutions

Kyoto Prefectural University of Medicine

Kyoto University

National Institute of Diabetes and Digestive and Kidney Diseases

ProQuest (United States)

Nara City Hospital

The Japanese Society of Gastroenterological Surgery

Kyoto City Hospital

Tohoku University

Kyoto first Red Cross hospital

Nagoya University

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Citation

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Pirfenidone Regulates Intestinal Fibrosis Through the Inhibition of HSP47 Expression in a Rat Colitis Model

Gastroenterology (2011)

Ken Inoue Yuji Naito Tomohisa Takagi Natsuko Hayashi Yasuko Hirai

Pirfenidone

10.1016/s0016-5085(11)63194-6

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Citations (1)

Toxic Megacolon Associated with Cytomegalovirus Infection in a Patient with Steroid-naïve Ulcerative Colitis

Internal Medicine (2012)

Ken Inoue Naoki Wakabayashi Kohei Fukumoto Shinya Yamada Nobukatsu Bito

Most cases of cytomegalovirus (CMV) colitis in patients with inflammatory bowel disease (IBD) occur in those treated with immunosuppressants and/or corticosteroids. We herein present the case of a 57-year-old man with toxic megacolon associated with CMV colitis in corticosteroid-naïve ulcerative colitis (UC). To date, there have been only eight previous case reports of CMV colitis in steroid-naïve UC. We discuss the need to consider CMV colitis when making a differential diagnosis of patients with refractory UC who are not receiving corticosteroid treatment.

Toxic megacolon

Cytomegalovirus

Megacolon

10.2169/internalmedicine.51.8145

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Citations (11)

Helicobacter pylori infection might have a potential role in hepatocyte ballooning in nonalcoholic fatty liver disease

Journal of Gastroenterology (2015)

Yoshio Sumida Kazuyuki Kanemasa Shunsuke Imai Kojiro Mori Saiyu Tanaka

Surgical oncology

Colorectal Surgery

Liver disease

10.1007/s00535-015-1039-2

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Citations (76)

Utility of a little phlebotomy intermittently just before intravenous injection of glycyrrhizin for patients with chronic hepatitis C

The Japanese journal of gastro-enterology (2007)

Yoshio Sumida Kazuyuki Kanemasa Kohei Fukumoto Naohisa Yoshida Kyoko Sakai

We performed a small phlebotomy (50 ml) intermittently just before intravenous injection of glycyrrhizin (GL) in eight patients with chronic hepatitis C and continued this therapy until their serum ferritin levels dropped below 20 ng/ml without any changes of GL dosage. No patients had complications but one patient holded treatment according to their wishing. In seven patients who completed this therapy, the average amount of phlebotomized blood was 1221 +/- 1055 ml, their serum ferritin value significantly fell from 253 +/- 233 ng/ml to 18+/-5 ng/ml (p=0.038). Serum ALT levels also significantly decreased from 74 +/- 22 IU/L to 41 +/- 12 IU/L (p=0.001). Small intermittent phlebotomies before GL injection may be a effective treatment for hepatitis C.

Glycyrrhizin

Phlebotomy

Intravenous Infusions

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[A case of peripheral facial nerve palsy with cryoglobulinemia and chronic thyroiditis occurring during interferon plus ribavirin therapy for chronic hepatitis C].

PubMed (2007)

Yoshio Sumida Kazuyuki Kanemasa Kohei Fukumoto Naohisa Yoshida Kyoko Sakai

A 42-year-old woman with chronic hepatitis C has visited our hospital since October 2003. Liver biopsy revealed chronic hepatitis (A1/F1) . Therapy was initiated with interferon (IFN) alpha-2b and ribavirin in February 2004. Two months later, the patient developed left facial weakness. Laboratory findings showed cryoglobulinemia and abnormal thyroid function without any evidence of other viral infections. Idiopathic peripheral facial nerve palsy was diagnosed. IFN was discontinued at week 9 of therapy, but she obtained sustained virological response and her symptoms resolved at 6 month after the withdrawal.

Hepatitis C

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Citations (1)

Detection of Nε-(hexanoyl)lysine in the tropomyosin 1 protein in N-methyl-N'-nitro-N-nitrosoguanidine-induced rat gastric cancer cells

Journal of Clinical Biochemistry and Nutrition (2011)

Hitomi Okada Yuji Naito Tomohisa Takagi Megumi Takaoka Tomoko Oya‐Ito

Nε-(Hexanoyl)lysine, formed by the reaction of lysine with n-6 lipid hydroperoxide, is a lipid peroxidation marker during the initial stage of oxidative stress. The aim of the present study is to indentify Nε-(hexanoyl)lysine-modified proteins in neoplastic transformed gastric mucosal cells by N-methyl-N’-nitro-N-nitrosoguanidine, and to compare the levels of these proteins between gastric mucosal cells and normal gastric cells. Much greater fluorescence of 2-[6-(4'-hydroxy)phenoxyl-3H-xanthen-3-on-9-yl]benzoic acid, an index of the intracellular levels of reactive oxygen species, was observed for gastric mucosal cells compared to normal gastric cells. Nε-(Hexanoyl)lysine-modified proteins were detected by SDS-PAGE or two-dimensional electrophoresis and Western blotting using anti-Nε-(hexanoyl)lysine polyclonal antibody, and a protein band of between 30–40 kDa was clearly increased in gastric mucosal cells compared to normal gastric cells. Two Nε-(hexanoyl)lysine-modified protein spots in gastric mucosal cells were identified as the tropomyosin 1 protein by mass spectrometry using a MASCOT search. The existence of Nε-(hexanoyl)lysine modification in tropomyosin 1 was confirmed by Western blotting of SDS-PAGE-separated or two-dimensional electrophoresis-separated proteins as well as by the immunoprecipitation with anti-tropomyosin 1 antibody. These data indicate that Nε-(hexanoyl)lysine modification of tropomyosin 1 may be related to neoplastic transformation by N-methyl-N'-nitro-N-nitrosoguanidine in gastric epithelial cells.

Tropomyosin

Polyclonal antibodies

10.3164/jcbn.11-39

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Citations (7)

Evaluation of Autofluorescence Colonoscopy for Diagnosis of Superficial Colorectal Neoplastic Lesions

Gastrointestinal Endoscopy (2009)

Ken Inoue Naoki Wakabayashi Nobukatsu Bitou Kohei Fukumoto Shinya Yamada

Autofluorescence

10.1016/j.gie.2009.03.1131

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Citations (2)

Rhodium-Catalyzed Oxidation of Unprotected Peptide Thiols to Disulfides with Oxygen in Water

ACS Catalysis (2020)

Mieko Arisawa Kohei Fukumoto Masahiko Yamaguchi

Unprotected peptide thiols are efficiently oxidized to peptide disulfides in homogeneous water. The oxidation reaction proceeds under ambient pressure of oxygen (1 atm), using a readily available RhCl3 catalyst. The reaction can also tolerate amino acid residues Gly, Ala, Val, Len, Ile, Phe, Ser, Tyr, Lys, Asp, Gln, His, Trp, and Met. The mechanism involving the formation of unstable sulfenic acid is provided.

Sulfenic acid

10.1021/acscatal.0c04799

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Citations (19)

Rhodium-Catalyzed Oxidation of Unprotected Peptide Thiols to Disulfides with Oxygen in Water

The Pharmaceutical Society of Japan (2021)

Kohei Fukumoto

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The Efficacy of Short-Duration Polyethylene Glycol plus Electrolytes for Improving Bowel Preparation of Colonoscopy in Patients with Chronic Constipation

Gastroenterology Research and Practice (2020)

Naohisa Yoshida Yoshikazu Inagaki Kohei Fukumoto Hiroyuki Yoriki Yutaka Inada

This multicenter retrospective study was conducted from September 2019 to September 2020 at 5 related institutions among patients ≥ 20 years old diagnosed with chronic constipation whose previous colonoscopic BP had had a fair or poor Aronchick score. Two or four sachets of PEG+E (13.7 or 27.4 g/day) were prescribed for 1 week before colonoscopy. We analyzed the rate of improvement in BP, effect-related factors, spontaneous bowel movements (SBMs), stool consistency, improvement of constipation symptoms, and adverse events.We evaluated 106 cases (56 males) with an average age of 69.5 ± 9.4 years old (≤74 years old: 68 cases, ≥75 years old: 38 cases). The improvement rate of BP was 72.6%, and the insertion time and pain score also improved. A performance status of 1 or 2 was associated with poor BP. SBMs (times/week) increased from 4.0 ± 1.9 to 6.1 ± 2.6 (p < 0.001). The overall improvement rates of SBMs, stool consistency, symptoms of constipation, and rate of adverse events were 58.5%, 90.6%, 59.4%, and 6.6%, respectively, showing no significant differences with regard to age or gender.Short-duration PEG+E was effective for improving poor BP and chronic constipation.

Functional constipation

Bowel preparation

10.1155/2020/8886073

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Citations (11)