E. Agapitos

Athens State University

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P Davaris

National and Kapodistrian University of Athens

Petros M. Pavlopoulos

National and Kapodistrian University of Athens

N Kavantzas

National and Kapodistrian University of Athens

Panagiotis Davaris

National and Kapodistrian University of Athens

Constantinos N. Christodoulou

Laiko General Hospital of Athens

Nikolaos Kavantzas

National and Kapodistrian University of Athens

Penelope Korkolopoulou

National and Kapodistrian University of Athens

E. Patsouris

National and Kapodistrian University of Athens

Michael Safioleas

Athens State University

K. Aroni

Andreas Sygros Hospital

Cooperative Institutions

National and Kapodistrian University of Athens

Athens State University

Laiko General Hospital of Athens

Athens Medical Center

University General Hospital Attikon

Hippocration General Hospital

Alexandra Hospital

Evangelismos Hospital

University of Ioannina

University of Crete

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[Primary angiosarcoma of the spleen. Apropos of a new case].

PubMed (1989)

I Karaïtianos O Boudouris Dimitrios G. Karamanolis K Konzoglou Nikolaos Kavantzas

Primary tumor

Splenic disease

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Citations (0)

Evaluation of the cyclin-dependent kinase inhibitor p21Cip1 in epithelial ovarian tumors of low malignant potential and adenocarcinomas.

PubMed (2003)

Ioannis Vassilopoulos Penelope Korkolopoulou A. E. Konstantinidou Efstratios Patsouris Christos Eftichiadis

In view of the controversial information on the significance of the cyclin-dependent kinase inhibitor p21Cip1 in ovarian cancer, we conducted a retrospective investigation to clarify the relationships of this protein to proliferation rate, clinicopathological variables and prognosis of epithelial ovarian tumors.Paraffin-embedded tissue from 43 ovarian tumors of low malignant potential (LMP) and 82 primary ovarian adenocarcinomas were stained immunohistochemically for p21Cip1, p53 protein and Ki-67 antigen (a marker of cell proliferation).p21Cip1 levels were significantly higher in LMP tumors (p<0.001) as well as in early stage adenocarcinomas (p=0.021) and those associated with minimal residual disease (p=0.008). However, no relationship existed between p21Cip1 expression and the proliferation rate of adenocarcinomas or LMP tumors. In the vast majority of LMP tumors p21Cip1 expression was not accompanied by p53 accumulation. This p21Cip1-positive/p53-negative phenotype prevailed in the early stage (p=0.026), lower grade (p=0.018) adenocarcinomas as well as in those left with minimal residual disease (p=0.059). In patients with lower grade adenocarcinomas, decreased p21Cip1 expression was adversely related to poor overall survival on its own (p=0.0500) and when combined with p53 protein overexpression (p=0.0323). In multivariate analysis, only the stage remained as the independent predictor of survival.Decreased p21Cip1 expression is related to several indicators of aggressiveness in ovarian adenocarcinomas and seems to be differentially regulated in LMP tumors and adenocarcinomas. On the contrary, deregulation of p21Cip1 expression does not seem to participate in the pathogenesis of LMP tumors. Furthermore, although p21Cip1 alone or combined with p53 is of prognostic significance in lower grade adenocarcinomas, it does not appear to add to the information gained from traditional prognosticators.

Ovarian tumor

10.14670/hh-18.761

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Citations (9)

Association of Single Umbilical Artery with Congenital Malformations of Vascular Etiology

Pediatric and Developmental Pathology (1998)

Petros M. Pavlopoulos Anastasia Konstantinidou E. Agapitos Constantinos N. Christodoulou Panagiotis Davaris

The possible association of a single umbilical artery (SUA) with malformations of vascular etiology is investigated in this study. Four hundred twelve fetal and embryonic autopsies showing one or more congenital malformations, collected over 7 years, were reviewed. Microscopic confirmation of a SUA was evident in 20 cases (4.85%). The two subgroups with 2 ( n A = 20) or 3 umbilical vessels ( n B = 392) were compared with each other, in relation to the frequency of malformations per organ system. In the group of fetuses with congenital malformations, no association was observed between SUA and the incidence of CNS, cardiac, pulmonary, or genital malformations. However, there was a significantly higher incidence of atresia of hollow organs ( P = 0.003), renal aplasia ( P = 0.034), and limb reduction defects (LRD) ( P = 0.0383) when only a single umbilical artery was present. This suggests a possible etiopathogenetic association of SUA with congenital malformations of vascular etiology. Furthermore, the findings of our study suggest that prenatal identification of a SUA warrants a thorough search for atresias, renal aplasia, and LRD-type malformations.

Single umbilical artery

Etiology

Aplasia

Congenital malformations

Anal atresia

Umbilical artery

Pulmonary atresia

10.1007/s100249900067

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Citations (19)

Primary causes of perinatal death

Pathology - Research and Practice (1986)

E. Agapitos Efi Kouri L. Alexacos C. Bacoula N. Papacharalampous

Hyaline

10.1016/s0344-0338(86)80049-8

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Citations (3)

Immunohistochemical detection of fibronectin in early and advanced atherosclerosis.

PubMed (1995)

S. Kakolyris Petros Karakitsos Maria Tzardi E. Agapitos

Fibronectin is known to be involved in the pathogenesis of atherosclerosis. We therefore applied paraffin-section immunohistochemistry, which permits detailed morphological analysis of the tissue distribution of fibronectin, in order to evaluate the alterations of fibronectin in terms of quantity and localization during the progression of atherosclerosis in humans. In 48/60 (80%) cases (p < 0.005) with early atherosclerotic lesions we found intense fibronectin staining presenting a distribution in continuous fibrils in the subendothelium around the fibrous plaque. The total amount of fibronectin was elevated. In 51/60 (85%) cases (p < 0.001) presenting advanced or complicated atherosclerotic lesions, the characteristic distribution of fibronectin in continuous fibrils was interrupted, fibronectin strands were fragmented and in regions where the sclerotic process was complete, fibronectin seemed to be almost absent. These findings reveal that fibronectin during atherosclerosis plays a role similar to that reported during the wound healing process and demonstrate a close relationship between quantity and topographical distribution of fibronectin and evolution of atherosclerosis. Further studies are required to determine whether fibronectin could be used as a marker for evaluation of the severity of atherosclerotic lesions.

Pathogenesis

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Prenatal ultrasonographic detection of the tracheal atresia sequence

Ultrasound in Obstetrics and Gynecology (1997)

Dimitrios Kassanos C. N. Christodoulou E. Agapitos Petros M. Pavlopoulos N. Pagalos

Abstract We report on a rare case of tracheal atresia, without fistula, in a 29 weeks' female fetus. The abnormality was detected by prenatal ultrasonography, which demonstrated a bilateral and uniform hyperechogenicity and enlargement of the lungs, associated with ascites and moderate oligohydramnios. We suggest that oligohydramnios may be helpful in distinguishing the upper respiratory tract obstruction from congenital cystic adenomatoid malformation of the lungs, type III. A morphometric study revealed a three‐fold more dense pulmonary vasculature in comparison with two control cases of the same gestational age. The pathological finding of pulmonary and vascular hyperplasia as well as the pathophysiology of the syndrome are discussed. Copyright © 1997 International Society of Ultrasound in Obstetrics and Gynecology

Pulmonary Hypoplasia

10.1046/j.1469-0705.1997.10020133.x

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Citations (17)

Simon-Emmanuel Duplay’s (1836–1924) essay on cancer contagion

Oncology Reviews (2010)

Marianna Karamanou E. Agapitos Georges Androutsos

Simon-Emmanuel Duplay was a distinguished example of the French clinicopathological school and his researches on cancer inaugurated the modern period in oncology. In his book entitled Les tumeurs, he presents and analyses his research and those of his contemporaries on cancer contagion.

10.1007/s12156-010-0069-5

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Citations (1)

Cell proliferation rate and nuclear morphometry in Roberts syndrome

Clinical Genetics (1998)

Petros M. Pavlopoulos A. E. Konstantinidou E. Agapitos Panagiotis Davaris

Roberts syndrome (RS) is a rare autosomal recessive disorder characterized primarily by symmetric reduction anomalies of all limbs, growth retardation and craniofacial abnormalities. Most RS patients are reported to present a typical abnormality of their constitutive heterochromatin, accompanied by abnormal cytological growth characteristics. We present an extremely severe case of an RS fetus, karyotypically documented, with a clinical presentation including growth deficiency, tetraphocomelia, frontal meningocele, craniofacial abnormalities and penile enlargement with hypospadias. Nuclear morphometrical analysis in tissues of various organs revealed a reduced nuclear size in RS as compared to normal controls, and statistically significant differences in morphometric parameters related to the nuclear shape. Immunohistochemical study of the same organs showed a reduced expression of proliferating cell nuclear antigen in the presented case, thus indicating a decreased cell proliferation rate in RS. Our results reconfirm previously reported findings in cultured fibroblasts of RS cases, thereby reinforcing on a histologic level, the hypothesis that reduced cell proliferation may be involved in the growth retardation and the reduction abnormalities observed in RS.

Abnormality

Growth retardation

Craniofacial abnormality

10.1111/j.1399-0004.1998.tb03772.x

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Citations (9)

Intrafetal prostaglandin F2α administration for uterine evacuation in a case of intrauterine death

European Journal of Obstetrics & Gynecology and Reproductive Biology (1996)

Constantinos N. Christodoulou Angelos E. Liapis E. Agapitos Christophoros A. Zonas P.A. Zourlas

Prostaglandin F2alpha

Fetal death

Uterine rupture

10.1016/0301-2115(95)02289-9

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Citations (0)

Rationalization of the Activity of Medical Ozone on Intervertebral Disc A Histological and Biochemical Study

Rivista di Neuroradiologia (2001)

E. Iliakis Vasilios Valadakis Demitrios H. Vynios C.P. Tsiganos E. Agapitos

Ozonetherapy is used for the treatment of immunodeficiency syndromes as well as for the treatment of cardiovascular disease. It is also used for the treatment of low back-pain with promising results although it is not yet well established. The aim of the current study is the presentation of the effects of ozonetherapy injected intradiscally or paravertebrally. We present the histological, immunological and biochemical changes in vertebral discs. Our material consist of human specimens as well as New Zealand rabbits.

Intervertebral Disc

Degenerative Disc Disease

rationalization

10.1177/19714009010140s105

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Citations (93)