Yi-Fang Meng

Tongji Hospital

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Jiong Lu

Sichuan University

Wei Zhu

Hunan Children's Hospital

Jian-Jun Tao

Changshu No.1 People's Hospital

Yan Wu

Northeast Forestry University

Qian Xing

Dalian Medical University

Zheng Gu

First Affiliated Hospital of Soochow University

Qian Xing

Affiliated Hospital of Jiangsu University

Qi Pu

Tongji Hospital

Jinyu Wang

National Institute for Communicable Disease Control and Prevention

Daihui Yang

Second Affiliated Hospital of Nanjing Medical University

Cooperative Institutions

Changshu No.1 People's Hospital

Changshu No. 2 People's Hospital

Soochow University

Huazhong University of Science and Technology

First Affiliated Hospital of Soochow University

East China University of Science and Technology

Peking University

Jiangsu University

Chinese Academy of Medical Sciences & Peking Union Medical College

Chinese Academy of Sciences

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Identification of lncRNAs involved in biological regulation in early age-related macular degeneration

International Journal of Nanomedicine (2017)

Wei Zhu Yi-Fang Meng Qian Xing Jian-Jun Tao Jiong Lu

Background: Age-related macular degeneration (AMD) is one of the most common causes of adult blindness in developed countries. However, the role of long noncoding RNAs (lncRNAs) in the development and progression of early AMD is unclear. Methods: We established the lncRNA profile of early AMD by reannotation of microarrays from the gene expression omnibus database. Quantitative real-time polymerase chain reaction was used to determine the expression of selected lncRNAs. Results: The expression profiles of 9 cases of AMD and 7 controls were studied. A total of 266 differentially expressed genes (DEGs) were detected (94 upregulated and 172 downregulated). Among all the DEGs, 64 were lncRNAs. Advanced bioinformatics analyses demonstrated that differentially expressed lncRNAs could play significant roles in visual perception, sensory perception of light stimulus, and cognition. The pathway analyses showed that the two most significantly influenced Kyoto Encyclopedia of Genes and Genomes pathways were those of phototransduction and purine metabolism. By the analyses of the key lncRNAs, it was found that RP11-234O6.2 was downregulated in the aging retinal pigment epithelium (RPE) cellular model. Exogenous RP11-234O6.2 treatment led to increased cell viability and improved apoptosis but it did not affect the cell migration ability of aging RPE cells. Conclusion: This study indicated that lncRNAs are differentially expressed in early AMD and may produce important regulative effects. An lncRNA, RP11-234O6.2, might be involved in the biological regulation of early AMD and have therapeutic potential. Keywords: age-related macular degeneration, lncRNAs, microarray, bioinformatics analyses

10.2147/ijn.s140275

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Clinical Application Value of a Preset Marking Line in Lacrimal Endoscopic Surgery

Chinese Journal of Optometry & Ophthalmology (2020)

Pan Xiao Daihui Yang Zhengru Huang Qian Xing Jian-Jun Tao

Objective: To explore the clinical application value of a preset marking line in lacrimal endoscopic surgery and evaluate its effect on surgical complications. Methods: This was a prospective analysis of clinical data from 60 patients (60 eyes) with lacrimal duct obstruction who had lacrimal endoscopic surgery in Changshu No.2 People's Hospital from June 2015 to December 2018. All patients were divided into two groups, a control group or observation group according to the even or odd numbers assigned to hospital patients. The control group (odd numbers) had no intra-surgery preset marking line. The observation group (even numbers) had an intra-surgery preset marking line. The complications of lacrimal duct mucosa injury, hemorrhage, perforation (false passage), eyelid edema and postoperative hemorrhage were observed and recorded. The data were analyzed by a Chi-square test. Results: In the observation group, the number of preset marking lines could be clearly observed during surgery, and combined with the position of the lacrimal endoscope, could be determined by the anatomical characteristics of the lacrimal passage. One marker line could be observed in the lacrimal canaliculi. The convergence of two marker lines could be observed in the common canaliculus. Two marker lines with an enlarged space could be observed in the lacrimal sac. Two marker lines with mucosal folds could be observed in the nasolacrimal duct. The incidence of lacrimal mucosal injury was 16% (χ2=8.543, P=0.003), hemorrhage incidence was 13% (χ2=8.718, P=0.003) and eyelid edema incidence was 10% (χ2=4.069, P=0.044) in the observation group, which were significantly lower than the incidences in the control group (52%, 52% and 35%, respectively). One case of perforation (false passage) occurred in the control group, which was not statistically significant compared with the observation group (χ2=0.001, P=0.973). There was no statistically significant difference in the incidence of postoperative hemorrhage between the groups (χ2=1.898, P=0.168). Moreover, all patients in the two groups had a small amount of hemorrhage, which did not affect the operation after intraoperative water injection. Patients with a small amount of postoperative hemorrhage stopped bleeding within 2 days. Conclusions: The application of preset marking lines for lacrimal endoscopic surgery can better control the endoscopic examination and surgery, and can accurately identify the location site of the surgery, which can reduce the incidence of surgical complications. Key words: lacrimal endoscope; lacrimal duct stents; preset marker line; lacrimal duct obstruction

Lacrimal duct

Lacrimal sac

Nasolacrimal Duct Obstruction

Lacrimal canaliculi

Perforation

10.3760/cma.j.issn.1674-845x.2020.01.011

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Citations (0)

Correction: Antiphospholipid Antibody and Risk of Retinal Vein Occlusion: A Systematic Review and Meta-Analysis

PLoS ONE (2016)

Wei Zhu Yan Wu Ming Xu Jinyu Wang Yi-Fang Meng

[This corrects the article DOI: 10.1371/journal.pone.0122814.].

Retinal Vein

10.1371/journal.pone.0157536

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Citations (6)

Association of alcohol intake with risk of diabetic retinopathy: a meta-analysis of observational studies

Scientific Reports (2017)

Wei Zhu Yi-Fang Meng Yan Wu Ming Xu Jiong Lu

Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM). The associations of alcohol intake with DR risk have demonstrated contradictory results. Relevant studies were identified by searching electronic databases (Medline, EMBASE and Web of Science) until May 2016. We identified a total of 12,875 DR cases among 37,285 participants in 15 observational studies. The pooled estimation of all the included observational studies was 0.91 (95% CI, 0.79 to 1.06) in a random-effect model. Analyses stratified by study design showed no significant association between alcohol intake and DR incidence in cohort, case control or cross-sectional studies. In the subgroup analyses, neither beer nor spirits intake were associated with DR risk. Furthermore, it was interesting to find that protective effects were detected in the wine (OR = 0.77, 95% CI = 0.64 to 0.92) and sherry (OR = 0.22, 95% CI = 0.05 to 0.95) groups. In conclusion, this current meta-analysis demonstrated that alcohol intake was not associated with risk of DR. Subgroup analysis by alcoholic beverage types showed that wine consumption would reduce the incidence of DR. In the future, more large-scale prospective studies with detailed alcohol subtypes and contents are still warranted to clarify the association.

Association (psychology)

10.1038/s41598-017-00034-w

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Citations (84)

Antiphospholipid Antibody and Risk of Retinal Vein Occlusion: A Systematic Review and Meta-Analysis

PLoS ONE (2015)

Wei Zhu Yan Wu Ming Xu Jinyu Wang Yi-Fang Meng

Background Retinal vein occlusion (RVO) is a common retinal vascular disease and it is one of the most frequently reported causes of visual damage and blindness in the elderly. The current study investigated the potential association between antiphospholipid antibodies (APLA) and RVO risk by conducting a meta-analysis of case–control studies. Methods A systematic literature search of Pubmed and Embase databases was conducted in August 1st, 2014. Odds ratios (ORs) were used to evaluate the associations between APLA and the incidence of RVO. A random-effects model was obtained for the quantitative synthesis. Results A total of 11 studies were included in this meta-analysis. A meta-analysis of all studies assessing the risk of RVO revealed that APLA was associated with a statistically increased risk of RVO incidence (OR = 5.18, 95% CI = [3.37, 7.95]). The association between anticardiolipin antibodies (ACA) and the risk of RVO was significant (n =8, OR = 4.59, 95% CI = [2.75, 7.66]). However, the association between lupus anticoagulants (LA) and risk of RVO was non-significant (n = 5, OR = 3.90, 95% CI = [0.99, 15.37]). No significant publication bias was found in the 11 selected studies. Conclusion APLA was significantly associated with the risk of RVO. Advanced analyses showed that ACA rather than LA affected the risk of RVO. Additional well-designed and well-conducted epidemiological studies are required to further our understanding of the relationship between APLA and RVO risk.

Retinal Vein

10.1371/journal.pone.0122814

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Citations (37)

Lower Serum Vitamin D Level Was Associated with Risk of Dry Eye Syndrome

Medical Science Monitor (2017)

Yi-Fang Meng Jiong Lu Qian Xing Jian-Jun Tao Pan Xiao

BACKGROUND:To determine the association between serum 25(OH)D and dry eye syndrome (DES) incidence. This study was also designed to determine whether serum 25(OH)D levels were associated with ocular parameter of DES patients. MATERIAL AND METHODS:This is a case-control study with 70 DES cases and 70 healthy controls. Clinical data included body mass index (BMI, kg/m²), smoking history, diabetes, and blood pressure. Serum 25(OH)D was chosen as the main parameter and reflected the level of vitamin D. The DES parameters included ocular surface disease index (OSDI) scales, tear film breakup time (TBUT) and Schirmer test I. The differences in each parameter between case and control groups were detected and the association of serum 25(OH)D and DES parameter were detected. RESULTS:It was shown that 25(OH)D levels were lower in patients with DES than in healthy controls. When the 25(OH)D levels was stratified, vitamin D deficiency was more common in the DES cases. In advanced studies, it was found that there were statistically significant associations between serum 25(OH) D levels and the Schimer test, TBUT, and OSDI scales. CONCLUSIONS:A significant association between serum 25(OH)D level and DES incidence was detected in this study. Considering the relatively small sample size of this study, larger studies are needed in the future.

10.12659/msm.901857

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Citations (23)

Association Between Single Nucleotide Polymorphisms in the Vitamin D Receptor and Incidence of Dry Eye Disease in Chinese Han Population

Medical Science Monitor (2019)

Yi-Fang Meng Qian Xin Jiong Lu Pan Xiao Li J

BACKGROUND Dry eye disease (DED) is a chronic dysfunction of the ocular surface and has become an important public problem. Vitamin D receptor (VDR) gene polymorphism has been found to be associated with different kinds of diseases. The relationship between single nucleotide polymorphisms (SNPs) in the VDR gene should be studied. MATERIAL AND METHODS In the present case-control study, we investigated the association of VDR gene polymorphism with DED risk. Clinical data including age, gender, body mass index (BMI, kg/m²), smoking history, diabetes, and blood pressure were recorded. Serum 25-hydroxy vitamin D (25[OH]D) was chosen as the main parameter that reflected the level of vitamin D. We identified SNPs of VDR gene Apa-1, Bsm-1, Fok-1, and Taq-1 in both DED cases and healthy controls. RESULTS A total of 124 DED cases and 135 healthy controls were included in this study. It was reported that aa in Apa-1 (OR=2.803, 95% CI, 1.350-5.820) and tt in Taq-1 (OR=0.362, 95% CI, 0.141-0.930) were associated with increased the risk of DED. Analysis of the allele frequencies of VDR gene polymorphisms among DED patients and healthy controls showed that allele differences in Apa-1 were significantly associated with higher risk. CONCLUSIONS SNPs of VDR gene (Apa-1 and Taq-1) were associated with the risk of DED. No significant association of Bsm-1 and Fok-1 in VDR gene demonstrated significant effect in the incidence of DED. Thus, we found that several SNPs of VDR gene could provide significant pathogenic effects in the risk of DED.

Gene polymorphism

10.12659/msm.915434

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Citations (9)

Observation on the efficacy of lacrimal duct stents for lacrimal duct obstruction under lacrimal endoscope

Pan Xiao Jiong Lu Daihui Yang Jian-Jun Tao Qian Xing

Objective To observe the efficacy of lacrimal duct stents under lacrimal endoscope for the treatment of lacrimal duct obstruction with different position. Methods The data of 62 eyes of 56 cases with lacrimal duct obstruction under endoscope were examined and treated. All patients were divided into three groups, presaccal canalicular obstruction group, nasolacrimal duct obstruction group and refractory lacrimal passage obstruction group. All patients were followed up for 6 months after removed the tube stents, the efficacy of different groups were compared and analyzed. Results The recovery rate in presaccal canalicular group was 89.7%, effective rate was 100%. The recovery rate in nasolacrimal duct obstruction group was 82.1%, effective rate was 92.9%. The recovery rate in refractory lacrimal passage obstruction group was 20%, effective rate was 60%. Conclusion Application of the lacrimal endoscope in the treatment of presaccal canalicular obstruction and nasolacrimal duct obstruction had its unique advantage. Key words: Lacrimal ducts obstruction; Lacrimal endoscope; Stents

Lacrimal duct

Endoscope

Nasolacrimal Duct Obstruction

Nasolacrimal duct

Lacrimal sac

Refractory (planetary science)

Chronic dacryocystitis

10.3760/cma.j.issn.2095-1477.2017.07.012

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Fish Consumption and Age-Related Macular Degeneration Incidence: A Meta-Analysis and Systematic Review of Prospective Cohort Studies

Nutrients (2016)

Wei Zhu Yan Wu Yi-Fang Meng Qian Xing Jian-Jun Tao

The association between fish consumption and risk of age-related macular degeneration (AMD) is still unclear. The aim of the current meta-analysis and systematic review was to quantitatively evaluate findings from observational studies on fish consumption and the risk of AMD. Relevant studies were identified by searching electronic databases (Medline and EMBASE) and reviewing the reference lists of relevant articles up to August, 2016. Prospective cohort studies that reported relative risks (RRs) and 95% confidence intervals (CIs) for the link between fish consumption and risk of AMD were included. A total of 4202 cases with 128,988 individuals from eight cohort studies were identified in the current meta-analysis. The meta-analyzed RR was 0.76 (95% CI, 0.65–0.90) when any AMD was considered. Subgroup analyses by AMD stages showed that fish consumption would reduce the risk of both early (RR, 0.83; 95% CI, 0.72–0.96) and late (RR; 0.76; 95% CI, 0.60–0.97) AMD. When stratified by the follow-up duration, fish consumption was a protective factor of AMD in both over 10 years (n = 5; RR, 0.81; 95% CI, 0.67–0.97) and less than 10 years (n = 3; RR, 0.70; 95% CI, 0.51 to 0.97) follow-up duration. Stratified analyses by fish type demonstrated that dark meat fish (RR, 0.68, 95% CI, 0.46–0.99), especially tuna fish (RR, 0.58; 95% CI, 95% CI, 0.47–0.71) intake was associated with reduced AMD risk. Evidence of a linear association between dose of fish consumption and risk of AMD was demonstrated. The results of this meta-analysis demonstrated that fish consumption can reduce AMD risk. Advanced, well-designed, randomized clinical trials are required in order to validate the conclusions in this study.

Lower risk

Subgroup analysis

10.3390/nu8110743

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Citations (39)

Neutrophil/Lymphocyte Ratio as an Inflammatory Predictor of Dry Eye Disease: A Case-Control Study

Therapeutics and Clinical Risk Management (2021)

Yi-Fang Meng Qi Pu Qian Ma Wei Zhu Xinyu Li

The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been used as indicators of inflammation, however, their roles in dry eye disease (DED) patients require advanced study.A total of 104 DED cases and 97 healthy controls from January 2020 to May 2020 were enrolled in this study. The dry eye related clinical variables, including Schirmer I test, tear break-up time (TBUT), corneal fluorescein staining (CFS) and Ocular Surface Disease Index (OSDI), were detected in all the participants. Besides, the NLR and PLR pattern in DED cases were detected and their potential value as inflammatory predictors of DED were evaluated. In advanced analyses, the correlation between NLR and DED severity was examined.The NLR and PLR were 2.59 ± 1.25 and 117.48 ± 54.68 in the DED group, respectively, while they were 2.20 ± 1.24 and 115.48 ± 54.33 in the control group, respectively. The NLR was higher in the DED group (p = 0.027), however, PLR was not significantly different compared with the control group (p = 0.951). In advanced analyses, it was found that more severe TBUT, CFS, and OSDI scores were detected in the high NLR group (NLR ≥2.145, p = 0.003, 0.013, and 0.017, respectively) compared with the low NLR group (NLR <2.145).The NLR value, but not PLR, of DED patients was higher than that of healthy controls. The NLR could be used as an inflammatory predictor to estimate the severity of DED.

10.2147/tcrm.s298156

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Citations (13)