K. Sateesh Reddy

Dr. Reddy's Laboratories (India)

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Manojit Pal

University of Hyderabad

Suju C. Joseph

University of Kerala

G. Rajeshwar Reddy

Dr. Reddy's Laboratories (India)

T. Ram Reddy

Yogi Vemana University

D. Rambabu

Indian Agricultural Research Institute

Gamidi Rama Krishna

National Chemical Laboratory

K. Arun Kumar

Loyola University Chicago

Kishore V. L. Parsa

University of Hyderabad

C. Malla Reddy

Indian Institute of Technology Hyderabad

M. Sreenivasulu

KLE Technological University

Cooperative Institutions

University of Hyderabad

Dr. Reddy's Laboratories (India)

Indian Institute of Chemical Technology

Institute of Life Sciences

Osmania University

Dr. Reddy's Laboratories (United States)

Jawaharlal Nehru Technological University, Hyderabad

Andhra University

Acharya Nagarjuna University

National Dong Hwa University

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1,3-Bis(2,4,6-trimethylphenyl)imidazolium chloride in combination with triethylamine: an improved catalytic system for hydroacylation/reduction of activated ketones

Tetrahedron Letters (2010)

M. Sreenivasulu K. Arun Kumar K. Sateesh Reddy Kapil Kumar Pramod Kumar

Hydroacylation

Triethylamine

10.1016/j.tetlet.2010.12.022

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Citations (21)

ChemInform Abstract: Iodine Catalyzed Four‐Component Reaction: A Straightforward One‐Pot Synthesis of Functionalized Pyrroles under Metal‐Free Conditions.

ChemInform (2012)

G. Rajeshwar Reddy T. Ram Reddy Suju C. Joseph K. Sateesh Reddy Manojit Pal

Abstract Highly substituted pyrroles are synthesized under metal‐ and solvent‐free conditions by reaction of amines (I), 1,3‐dicarbonyl compounds (II), aldehydes (III) and nitromethane (IV).

Reaction conditions

Component (thermodynamics)

10.1002/chin.201232112

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Iodine catalyzed four-component reaction: a straightforward one-pot synthesis of functionalized pyrroles under metal-free conditions

RSC Advances (2012)

G. Rajeshwar Reddy T. Ram Reddy Suju C. Joseph K. Sateesh Reddy Manojit Pal

An iodine-catalyzed four-component reaction of 1,3-dicarbonyl compounds, amines, aldehydes and nitroalkanes afforded polysubstituted pyrroles under a metal free condition. Simplicity, low cost and good yields are the key features of this methodology. The mechanism of this four component process is discussed and structural elaboration of one of the compounds synthesized using Suzuki and Sonogashira coupling is presented.

Sonogashira coupling

Component (thermodynamics)

Coupling reaction

Reaction conditions

10.1039/c2ra00982j

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Citations (63)

ChemInform Abstract: 1,3‐Bis(2,4,6‐trimethylphenyl)imidazolium Chloride in Combination with Triethylamine: An Improved Catalytic System for Hydroacylation/Reduction of Activated Ketones.

ChemInform (2011)

M. Sreenivasulu K. Arun Kumar K. Sateesh Reddy Kapil Kumar Pramod Kumar

Abstract A combination of triethylamine and an NHC‐catalyst, generated in situ, efficiently promotes the reduction of α‐keto esters with benzaldehyde as hydrogen acceptor.

Triethylamine

Hydroacylation

Benzaldehyde

10.1002/chin.201117082

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Yb(OTf)3 mediated MCR: a new and regioselective approach towards polysubstituted pyrroles of pharmacological interest

RSC Advances (2012)

G. Rajeshwar Reddy T. Ram Reddy Suju C. Joseph K. Sateesh Reddy Chandana Lakshmi T. Meda

A regioselective synthesis of 1,2,3,4-tetrasubstituted pyrroles has been achieved via Yb(OTf)3-mediated 3-component reaction of amines, a 1,3-diketone and phenacyl bromide in a single pot. Yb(OTf)3 was identified as a reusable catalyst and a number of pyrrole derivatives were prepared by using this strategy. Single crystal X-ray diffraction study of a representative compound confirmed the substitution pattern on the central pyrrole ring. The crystal structure analysis of the same compound indicated the presence of a sheet-like molecular arrangement along the bc-plane present in the molecule. A possible mechanism for the regioselective formation of 1,2,3,4-tetrasubstituted pyrrole rings is discussed. A number of compounds synthesized showed PDE4 inhibitory properties when tested in vitro and two of them were identified as inhibitors of further interest.

Pyrrole

Phenacyl bromide

10.1039/c2ra21343e

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Citations (27)

In Situ FTIR Spectroscopic Monitoring of the Formation of the Arene Diazonium Salts and Its Applications to the Heck–Matsuda Reaction

Molecules (2020)

K. Sateesh Reddy Bandi Siva Divya Reddy Solipeta N. Reddy Naresh T. V. Pratap

This study depicts the use of a fiber-optic coupled Fourier transform infrared spectroscopy-attenuated total reflection (FTIR-ATR) probe for the in-depth study of arene diazonium salt formation and their utilization in the Heck–Matsuda reaction. The combination of these chemical reactions and in situ IR spectroscopy enabled us to recognize the optimum parameters for arene diazonium salt formation and to track the concentrations of reactants, products and intermediates under actual reaction conditions without time consuming HPLC analysis and the necessity of collecting the sample amid the reaction. Overall advantages of the proposed methodology include precise reaction times as well as identification of keto enol tautomerization in allylic alcohols supporting the ‘path a’ elimination mechanism in the Heck–Matsuda reaction.

Heck Reaction

Attenuated total reflection

10.3390/molecules25092199

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Citations (4)

Monitoring of Chemical Markers in Extraction of Traditional Medicinal Plants (Piper nigrum, Curcuma longa) Using In Situ ReactIR

Journal of AOAC International (2021)

K. Sateesh Reddy Bandi Siva Divya Reddy Solipeta Kumar Katragunta T. V. Pratap

Abstract Background The fingerprinting and quantification of marker compounds from medicinal plants is a domain of the herbal industry for quality/quantity control parameters. Objective The main objective of this study is the application of the in situ ReactIR technique for measuring the concentration of different components during the extraction process of different medicinal plants. Method In this study we have performed the extraction of two-marker compounds, viz. piperine from Piper nigrum and curcumin from Curcuma longa plants, using various solvents (dichloromethane and methanol). The progress of extraction was monitored using an in situ Fourier transform infrared (FTIR) probe instrument and an automated reactor. Results In this communication, using the in situ ReactIR technique we developed a method which demonstrates the relative quantification of marker analytes, optimizes extraction time and type of solvents to be used for different analytes during the extraction process. Conclusions To the best of our knowledge, this is the first report of relative quantification and structural information of marker compounds during the process of extraction using in situ FTIR. Highlights The present study highlights the real-time monitoring, in situ quantification, and structural information of marker compounds during the process of extraction of medicinal plants using in situ FTIR.

Piperine

10.1093/jaoacint/qsab025

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Citations (2)

Pd-mediated new synthesis of pyrroles: their evaluation as potential inhibitors of phosphodiesterase 4

Chemical Communications (2011)

G. Rajeshwar Reddy T. Ram Reddy Suju C. Joseph K. Sateesh Reddy L.S. Reddy

A sequential Pd-mediated multi-component reaction followed by Suzuki or Heck or Sonogashira coupling in a single pot has been developed for the synthesis of functionalized pyrroles as potential inhibitors of PDE4.

Sonogashira coupling

Suzuki reaction

Heck Reaction

10.1039/c1cc12321a

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Citations (60)

Multi-Faceted Rural Development

K. Sateesh Reddy

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