Ryan Levine

Cedars-Sinai Medical Center

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Jon Kobashigawa

Cedars-Sinai Smidt Heart Institute

S. Dimbil

Kaiser Permanente San Francisco Medical Center

J. Patel

Universitat de València

F. Esmailian

Cedars-Sinai Smidt Heart Institute

L. Czer

Cedars-Sinai Medical Center

M. Kittleson

Cedars-Sinai Medical Center

Babak Azarbal

Cedars-Sinai Smidt Heart Institute

D. Megna

Cedars-Sinai Smidt Heart Institute

Richard Cheng

Queen's University

Takuma Sato

Hokkaido University

Cooperative Institutions

Cedars-Sinai Medical Center

Cedars-Sinai Smidt Heart Institute

University of Minnesota

University of Illinois Chicago

Inserm

Alpha Star (United States)

Royal College of Surgeons in Ireland - Bahrain

Assistance Publique – Hôpitaux de Paris

Université Paris Cité

Paris Cardiovascular Research Center

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Acceptable Post–Heart Transplant Outcomes Support Temporary MCS Prioritization in the New OPTN|UNOS Heart Allocation Policy

Transplantation Proceedings (2020)

Heidi Reich Danny Ramzy J. Moriguchi S. Dimbil Ryan Levine

Impella

10.1016/j.transproceed.2020.04.1819

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Citations (19)

Quantitative myocardial tissue characterization by cardiac magnetic resonance in heart transplant patients with suspected cardiac rejection

Clinical Transplantation (2019)

Robert J.H. Miller Louise Thomson Ryan Levine S. Dimbil J. Patel

Abstract Distinct histopathologic changes occur in acute cellular rejection (ACR), antibody‐mediated rejection (AMR), and biopsy‐negative rejection (BNR). Cardiovascular magnetic resonance (CMR)‐based myocardial tissue characterization can be used to quantify these changes. We assessed T1, T2, and extracellular volume fraction (ECV) by CMR in patients with subtypes of rejection. T1, T2, and ECV were quantified at the mid‐ventricular level and compared between patients with and without rejection. The association between quantitative tissue characteristics and the combined outcome of death, retransplantation, heart failure hospitalization, or myocardial infarction was evaluated with a Cox‐proportional hazards model. In 46 patients, mean age 53.3 ± 13.7 years, 71.7% male, at a median of 7.4 years from transplant, average myocardial T1 was increased in BNR compared with no rejection (1057 vs 1012 msec, P = .006). Average myocardial T2 was elevated in all types of rejection, P < .05. In a cox‐proportional hazards model, higher T2 values were associated with an increase in the combined clinical outcome (adjusted HR 1.21, 95% CI 1.06‐1.37, P = .004) after adjusting for left ventricular mass index. Myocardial tissue characteristics are abnormal in all subtypes of rejection, and abnormal T2 quantified by CMR provides additional prognostic value.

Cardiac magnetic resonance

10.1111/ctr.13704

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Citations (10)

Abstract 18380: Use of the Annual Angiogram After Heart Transplantation: Are They All Necessary?

Circulation (2017)

Michael Johl T. Aintablian S. Dimbil Ryan Levine M. Kittleson

Introduction: Cardiac allograft vasculopathy (CAV) remains one of the major factors limiting long-term survival. According to the ISHLT registry, CAV incidence is approximately 30% at 5 years and 5...

Coronary angiogram

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Abstract 19615: Combined Heart-Kidney Transplantation Acceptable in Older Recipients: Outcomes From the UNOS Registry

Circulation (2017)

S. Dimbil Ryan Levine J. Patel Elizabeth Passano L. Czer

Introduction: Combined heart-kidney transplantation (HKTx) has proven to be an acceptable option in a subset of heart transplant patients with end-stage renal failure. It has been demonstrated that older transplant recipients have worse post-transplant outcome. We sought to evaluate whether older HKTx recipients (> 60 years) have increased mortality and worse post-transplant kidney function compared to younger patients (≤ 60 years) who undergo HKTx. Methods: Between 1989 and 2016 we identified 1207 HKTx patients from the United Network for Organ Sharing (UNOS) database. We stratified by age of the recipient (≤ 60 years, n=870 vs > 60 years, n=337) and by age of the donor ( 50 years). As older organs are usually placed in older recipients, we also assessed the demographics of all groups. Endpoints of this study included renal function in terms of creatinine and glomerular filtration rate (GFR) at 12 months after transplant and 1-year survival. With respect to survival, UNOS re...

Demographics

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THE CLINICAL IMPACT OF EARLY VERSUS LATE HLA DONOR-SPECIFIC ANTIBODY DEVELOPMENT AFTER HEART TRANSPLANTATION

Journal of the American College of Cardiology (2018)

Jonathan D. Davis S. Dimbil Ryan Levine J. Patel F. Esmailian

Cardiac allograft vasculopathy

Donor-Specific Antibodies

10.1016/s0735-1097(18)31210-5

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Association of vimentin antibody and other non-HLA antibodies with treated antibody mediated rejection in heart transplant recipients

Human Immunology (2020)

Xiaohai Zhang Ryan Levine J. Patel M. Kittleson L. Czer

Panel reactive antibody

Isoantibodies

10.1016/j.humimm.2020.09.003

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HLA-DQ mismatches stimulate de novo donor specific antibodies in heart transplant recipients

Human Immunology (2020)

Xiaohai Zhang E. Kransdorf Ryan Levine J. Patel Jon Kobashigawa

HLA-DQ

10.1016/j.humimm.2020.04.003

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DOES EX VIVO PERFUSION LEAD TO MORE OR LESS INTIMAL THICKENING IN THE FIRST-YEAR POST-HEART TRANSPLANTATION?

Journal of the American College of Cardiology (2018)

Takuma Sato Richard Cheng Babak Azarbal Ryan Levine S. Dimbil

Ex vivo

Cold ischemia

10.1016/s0735-1097(18)31517-1

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A RETROSPECTIVE REVIEW OF HOW THE NEW UNOS HEART TRANSPLANT DONOR ALLOCATION POLICY AFFECTED URGENT STATUS LISTING AND OUTCOMES IN STATUS 1, 2, AND 3 LISTING COMPARED TO THE OLD STATUS 1A

Journal of the American College of Cardiology (2020)

Danny Ramzy Robert Cole M. Kittleson Ryan Levine Dominic Emerson

Listing (finance)

10.1016/s0735-1097(20)31314-0

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Does ex vivo perfusion lead to more or less intimal thickening in the first‐year post–heart transplantation?

Clinical Transplantation (2019)

Takuma Sato Babak Azarbal Richard Cheng F. Esmailian J. Patel

Abstract Background The Organ Care System (OCS), an ex vivo heart perfusion platform, represents an alternative to the current standard of cold organ storage that sustains the donor heart in a near‐physiologic state. Previous reports showed that this system had significantly shortened the cold ischemic time from standard cold storage (CS). However, the effect of reduced ischemic injury against the coronary vascular bed has not been examined by intravascular ultrasound (IVUS). Methods Between August 2011 and February 2013, heart transplant (HTx) candidates enrolled in the PROCEED 2 trial were randomized to either CS or OCS. IVUS was performed at 4‐6 weeks (baseline) and repeated 1 year after transplantation. The change in maximal intimal thickness (MIT) and other clinical outcomes were examined. Results Thirty‐nine patients were randomized and underwent HTx by OCS (n=16) or CS (n=18). Of these, 18 patients (OCS: n=5, CS: n=13) with paired IVUS were examined. There were no significant differences in the change of MIT and other clinical outcomes between the groups. Conclusion The incidence of cardiac allograft vasculopathy in donor hearts preserved with the OCS versus CS was similar. These results suggest that this ex vivo allograft perfusion system is a promising and valid platform for donor heart transportation.

Ex vivo

Lead (geology)

10.1111/ctr.13648

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Citations (12)