From strain gauge arches applied directly to the longitudinal surface of the papillary muscle of the canine left ventricle, its force of contraction was recorded simultaneously with that on an epicardial segment of the ventricle immediately overlying it. Left ventricular and atrial pressures, as well as ECG and local electrograms were also recorded in a closed-heart, open-chest preparation. Active participation of the papillary muscle in the contractile processes of the whole heart is indicated, and under positive inotropic drive (stellate stimulation, administration of isoproterenol, norepinephrine) the force of contraction of this muscle is greatly augmented. During volume loading resulting from afterloading procedures (central vagus stimulation, methoxamine, aortic clamping) the papillary muscle participates in augmenting the contractile force, but in lesser proportion than when elicited by a direct positive inotropic procedure. The increase in contractile force during afterload was related to passive changes in length-tension relationships. Direct vagal innervation of the papillary muscle is indicated by distinct inhibition in contractile force during electrical excitation of the peripheral end of the cut vagosympathetic trunk, both in the paced and unpaced preparation.
The Bevatron accelerator at Lawrence Berkeley National Laboratory is the first DOE accelerator to be demolished. While there are many lessons learned from its demolition, this paper focuses on the following lessons learned that may be useful for other D and D projects: bounding project scope to ensure success, hazards mapping for focused characterization and remediation, establishing radiological evaluation criteria, and forecasting activation products. With D and D of many DOE accelerators likely to occur in the near future, these lessons learned should be considered in planning those projects. These lessons learned are likely to be applicable to other D and D projects as well. (authors)
In view of its comparative rarity, we feel that it is worth while reporting the following case, which was treated by continuous intramuscular drip pentose nucleotide and oral sodium n ticleinate.Case Record A married fitter aged 30 was first admitted to hospital on May 27, 1943, with a history of pains in the knees, ankles, and the left elbow, wrist, and fingers of five days' duration.He was a moderate drinker and smoker.The previous history included an attack of rheumatic fever at the age of 7.On examination his temperature was 100°F.(37.8°C.), pulse 80, espiration 22.He looked pale, but had no other gross physical signs.The urine was normal; the blood sedimentation rate was 78 mm. in one hour.He was thought to be suffering from acute rheumatism, and was given salicylates, with little or no effect.On June 1 an ulcer of the gum was noted, and three days later several more had appeared, with a lymphadenitis of the deep cervical glands.The white cell count was 2,400 per c.mm. (neutrophil polymorphs 17%, lymphocytes 69%, and monocytes 14%).Haemoglobin and red cell count were notmal.He was given
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