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10.4267/2042/25676

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Citations (6)

Immunosuppressive activity of Fusarium toxins. Effects on antibody synthesis and skin grafts of crude extracts, T2-toxin and diacetoxyscirpenol.

PubMed (1979)

Yvonne Rosenstein C. Lafarge‐Frayssinet G Lespinats F Loisillier P. Lafont

The inhibitory effect of crude Fusarium poae extracts, T2-toxin and diacetoxyscirpenol on synthesis of antibody to sheep red blood cells was investigated, as well as the effect of T2-toxin on skin graft rejection. Fusarium crude extracts, T2-toxin and diacetoxyscirpenol cause a significant reduction in thymus weight and inhibit responsiveness to sheep red blood cells. The effect on antibody synthesis was critically dependent on the drug doses used. The effect of an immunosuppressive dose of T2-toxin disappeared within 6 days after the end of the treatment. The administration of T2-toxin subsequent to immunization stops antibody synthesis. T2-toxin significantly prolongs the period required for skin graft rejection.

Diacetoxyscirpenol

Source

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Citations (106)

Production of mycophenolic acid by Penicillium roqueforti strains

Applied and Environmental Microbiology (1979)

P. Lafont J P Debeaupuis M. GAILLARDIN J Payén

Sixteen strains of Penicillium roqueforti Thom, isolated from blue-molded cheeses, were studied. In vitro, all of these strains produced mycophenolic acid, some on the order of 0.8 to 4 mg/g od dry culture. The greatest yields were obtained after 10 days of incubation of cultures at 15 degrees C. However, under some experimental conditions, mycophenolic acid was not alone responsible for the toxicity of culture extracts to chicken embryos.

Penicillium roqueforti

Incubation period

10.1128/aem.37.3.365-368.1979

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Citations (62)

Production de nidulotoxine par desAspergillus appartenant à différentes espèces

Experientia (1970)

P. Lafont J. Lafont

10.1007/bf02232565

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Citations (2)