A. Cardona

Instituto Tecnológico Metropolitano

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Johanna C. Arroyave-Ospina

University of Groningen

Jörn M. Schattenberg

University Medical Center of the Johannes Gutenberg University Mainz

Paul J. Thuluvath

Mercy Medical Center

Marina Berenguer

Hospital Universitari i Politècnic La Fe

Kathleen E. Corey

Massachusetts General Hospital

Humberto Aguilar

Regenstrief Institute

John Poulos

Cumberland Research Associates (United States)

Annarosa Floreani

University of Padua

Rifaat Safadi

Hadassah Medical Center

Stergios Kechagias

Linköping University

Cooperative Institutions

Inserm

Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas

Harvard University

Creative Research Enterprises (United States)

University of Chicago

Instituto de Salud Carlos III

Virginia Commonwealth University

Texas Liver Institute

Medical University of Vienna

Assistance Publique – Hôpitaux de Paris

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Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial

The Lancet (2019)

Zobair M. Younossi Vlad Ratziu Rohit Loomba Mary E. Rinella Quentin M. Anstee

Obeticholic acid

Steatohepatitis

Interim analysis

Clinical endpoint

Chronic liver disease

10.1016/s0140-6736(19)33041-7

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Citations (1,021)

Automatic Image Segmentation Method for In Vitro Wound Healing Assay Quantitative Analysis

IFMBE proceedings (2015)

A. Cardona Leandro Ariza-Jiménez Diego Uribe Johanna C. Arroyave-Ospina Fabián Cortés-Mancera

10.1007/978-3-319-13117-7_98

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The reduction of the expression of B-catenin and c-Myc is related to a better outcome in patients with AML

Annals of Oncology (2018)

A. Cardona Jeanette Prada-Arismendy Erwing Castillo Johanna C. Arroyave-Ospina

Background: Acute myeloid leukemia (AML) is a malignant clonal disorder characterized by mutations affecting myeloid differentiation, gene expression, and epigenetic profiles. Although treatment strategy depends on a genetic profile-based risk, the accuracy of this stratification system is highly variable. Changes in gene expression profiles of signaling pathways involved in hematopoietic development, such as Wnt/B-catenin, may contribute to the transformation, development, and maintenance of leukemic cells, and could be related to the clinical outcome. Methods: qRT-PCR assays were designed to quantify mRNA levels of c-Myc, and B-catenin in blood samples from nine newly diagnosed AML patients before and after treatment. 18S ribosomal RNA was used to normalize gene expression. Statistical analysis was conducted in R statistical software. Relative expression rates (rERs) were implemented to quantify relative changes in gene expression levels after induction. Results: c-Myc and B-catenin expression decreased after induction treatment. Additionally, the rERs of both genes were linearly correlated (r = 0.937, p = 0.0002), and patients who has persistence of the disease after treatment have a higher rER -in both c-Myc and B-catenin-, compared to those who achieve complete remission (c-Myc: p = 0.0066; B-catenin: p = 0.04). However, c-Myc and B-catenin rERs were greatly variable in patients who partially responded to induction. Conclusions: c-Myc and B-catenin are molecules from Wnt signaling pathway, related to activation of the molecular pathway. Patients who have a decrease in the expression of this genes are more likely to achieve complete remission than those who don't change the expression of this molecules. Further analyses are needed to determine the precise role of Wnt/B-catenin in AML therapy response. Legal entity responsible for the study: Instituto Tecnológico Metropolitano. Funding: Colciencias, grant 669-2014. Disclosure: All authors have declared no conflicts of interest.

10.1093/annonc/mdy314.018

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Citations (1)

Titanium dioxide modified with silver by two methods for bactericidal applications

Heliyon (2019)

Geraldine Durango-Giraldo A. Cardona Juan Felipe Zapata Martínez Juan Felipe Santa Robison Buitrago‐Sierra

"Titanium dioxide (TiO2) is a semiconductor material that exhibits antibacterial activity due to its photocatalytic properties under ultraviolet light. On the other hand, silver also exhibits strong antibacterial activity towards a wide range of microorganisms and TiO2 with silver addition exhibits more efficient photocatalytic properties than unmodified TiO2. In this work, TiO2 nanoparticles were synthesized by the hydrothermal method and modified with silver by two different methods: wet impregnation (Ex situ) and In situ incorporation. The antimicrobial activity of TiO2 nanoparticles synthesized and modified by both methods was evaluated against Escherichia coli and Staphylococcus aureus. The results showed that TiO2 nanoparticles have anatase phase. Also, spherical morphology with a mean particle size around 10.6 nm was obtained. The presence of silver in the modified TiO2 nanoparticles was confirmed by EDS and XPS. TiO2 particles modified by the Ex situ method, showed a better bactericidal activity compared to the particles modified by In situ incorporation method and TiO2 unmodified nanoparticles. This study demonstrated that both methods used to modify the titanium dioxide nanoparticles are effective as bactericidal materials and better results were found for the Ex situ method."

Titanium Dioxide

Silver nanoparticle

10.1016/j.heliyon.2019.e01608

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Citations (35)