Michael Quinn

Maine Medical Center

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Co-Authors

Debra L Zarro

Lehigh Valley Hospital-Pocono

Patricia A Gustafson

Eye Care Associates

Ralph M Montesano

Lehigh Valley Hospital-Pocono

David A Palanzo

Penn State Milton S. Hershey Medical Center

Norman J Manley

Lehigh Valley Hospital-Pocono

J.A. Rushforth

Leeds General Infirmary

Barbara-Anne Elmore

Lehigh Valley Hospital-Pocono

Malcolm I. Levene

University of Leeds

M I Levene

University of Leeds

Michael Ogundele

Bridgewater Community Healthcare NHS Foundation Trust

Cooperative Institutions

University College London

Great Ormond Street Hospital

Boston Children's Hospital

National Health Service

Bristol Royal Hospital for Children

University of Leeds

Great Ormond Street Hospital for Children NHS Foundation Trust

Leeds General Infirmary

University of Melbourne

Royal Children's Hospital

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Randomised double-blind controlled trial of effect of morphine on catecholamine concentrations in ventilated pre-term babies

The Lancet (1993)

Michael Quinn Jennifer Wild H G Dean R. Hartley J.A. Rushforth

Ductus arteriosus

10.1016/0140-6736(93)91472-x

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Citations (152)

Single Coronary Artery

Journal of the American College of Cardiology (2009)

Matthew Corbett James B. Powers Scott B. King Michael Quinn David Harris

10.1016/j.jacc.2008.05.067

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Citations (18)

Potential problem when using the new lower-prime hollow-fibre membrane oxygenators with uncoated stainless steel heat exchangers

Perfusion (1996)

David A Palanzo Norman J Manley Ralph M Montesano Michael Quinn Barbara-Anne Elmore

A prospective study was conducted to evaluate the trans-oxygenator pressure gradient across three different hollow-fibre membrane oxygenators during routine cardiopulmonary bypass (CPB). Sixty consecutive open-heart surgery patients were randomly divided into three groups each receiving a different model of membrane oxygenator. Inlet and outlet pressures, as well as patients' pressures, blood flow, revolutions per minute and tympanic membrane temperature were recorded every 15 min during CPB. Within the study groups, there were subsets of patients who exhibited high trans- oxygenator pressures. Although most of these episodes were transient and resolved over a period of time, there were several cases during which the high trans-membrane pressures persisted, resulting in decreasing oxygenator performance. In one such case, oxygenator change-out was required. After extensive analysis and review, the only similarities or correlation that could be made were with the marriage of the newer lower- prime hollow-fibre membrane oxygenators (with corresponding narrow blood path) and the integral uncoated stainless steel heat exchangers. Further study needs to be performed to pinpoint the mechanism and pathophysiology that are involved in this phenomenon.

Membrane oxygenator

Oxygenator

10.1177/026765919601100610

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Citations (21)

Effect of Trillium™ Biopassive Surface coating of the oxygenator on platelet count drop during cardiopulmonary bypass

Perfusion (1999)

David A Palanzo Debra L Zarro Ralph M Montesano Norman J Manley Michael Quinn

The new Trillium™ Biopassive Surface is a coating designed to minimize the adsorption of protein and the attachment of cells. In previous studies, we were able to demonstrate that, by coating the bypass circuit with small amounts of albumin, the drop in circulating platelet count seen with the newer low-prime hollow-fiber membrane oxygenators is eliminated. A study was undertaken to compare the Avecor Affinity™ oxygenator with albumin in the prime with the Trillium-coated Affinity. Fifty-six patients undergoing nonemergency open-heart surgery were randomly divided into two groups. One group (Albumin) received the Affinity oxygenator with 10 ml of 25% albumin added to the pump prime. The other group (Trillium) received the Trillium-coated Affinity oxygenator. To normalize the data for the effects of hemodilution, the mean net platelet count drop on bypass was calculated for each group. The Albumin group had a net platelet count drop of 0.81 ± 9.78%, while the Trillium group had a drop of 1.58 ± 13.0%. There was no significant statistical difference between the two groups. From our investigation, we concluded that Trillium Biopassive Surface coating affords the Affinity oxygenator the same protective effects on circulating platelet counts as adding albumin to the prime.

Oxygenator

Membrane oxygenator

10.1177/026765919901400610

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Citations (21)

Use of sedatives and muscle relaxants in newborn babies receiving mechanical ventilation.

Archives of Disease in Childhood (1992)

Malcolm I. Levene Michael Quinn

In the 1970s sedation or paralysis was rarely considered to be necessary in the ventilatory care of premature infants.We now recognise that infants who 'fight' the ventilator may be at increased risk of a number of important neonatal complications including intracranial haemorrhage and pneumothorax.There is no consensus view on the best way of managing these infants, nor what pharmacological preparations to use in reducing the risks of these complications.When formulating an approach to inhibiting spontaneous respira- tion in the ventilated neonate there are three important issues to be considered.These are (i) what are the hazards of the infant breath- ing out of synchrony with the ventilator?, (ii) what are the effects of stress and pain associ- ated with mechanical ventilation ?, and (iii) what are the possible adverse effects of drugs used to reduce struggling or stress?

10.1136/adc.67.7_spec_no.870

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Citations (36)

Vigabatrin with hormonal treatment versus hormonal treatment alone (ICISS) for infantile spasms: 18-month outcomes of an open-label, randomised controlled trial

The Lancet Child & Adolescent Health (2018)

Finbar O’Callaghan Stuart W. Edwards Fabienne Dietrich Alber Mario Cortina‐Borja Eleanor Hancock

Vigabatrin

Hormonal Therapy

Epileptic spasms

Prednisolone

10.1016/s2352-4642(18)30244-x

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Citations (146)

Treatment of asphyxiated newborns with moderate hypothermia in routine clinical practice: how cooling is managed in the UK outside a clinical trial

Archives of Disease in Childhood Fetal & Neonatal (2010)

Michael Quinn P. F Munyard

Azzopardi et al 1 report the experience of introducing total body cooling as a standard form of therapy for infants with moderate or severe perinatal asphyxia. It is notable that this publication includes only one level 2 neonatal intensive care unit of the 25 units providing data for the TOBY register (Royal Cornwall Hospital, Truro). The Royal Devon and Exeter Hospital (also a level 2 unit) has since joined the TOBY register having participated in the TOBY trial. Part of the success in recruitment to the TOBY trial was because of the trial being rolled out to many more units in the second phase of the trial. The Peninsula Neonatal network level 3 …

10.1136/adc.2009.176743

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Citations (6)

Effect of morphine on respiratory drive in trigger ventilated pre-term infants

Early Human Development (2000)

Michael Quinn A Vokes

Hyaline

Bolus (digestion)

Respiratory Rate

10.1016/s0378-3782(00)00082-7

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Citations (10)

Which central venous catheter for neonatal parenteral nutrition?

Clinical Nutrition (1992)

J.A. Rushforth G. Christopher Wood Michael Quinn John Puntis

Central venous catheter

10.1016/0261-5614(92)90249-p

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Citations (0)

Effect of surface coating on platelet count drop during cardiopulmonary bypass

Perfusion (1999)

David A Palanzo Debra L Zarro Norman J Manley Ralph M Montesano Michael Quinn

This study was designed to investigate the effect of surface coating on platelet count drop during cardiopulmonary bypass (CPB). Sixty patients undergoing open-heart surgery were randomly divided into three groups each receiving a different type of coated hollow-fiber membrane oxygenator. The patients were given either an uncoated oxygenator (noncoated group), an oxygenator coated with Carmeda® (Carmeda group) or an uncoated oxygenator with albumin in the priming solution (albumin group). Comparisons were made in platelet count pre-CPB, on bypass (15-25 min) and during the warming period. Calculations were used to account for the effect of hemodilution. The albumin group had significantly lower platelet count drops (-4.8 ± 7.1%) than the Carmeda group (11.0 ± 8.3%) and the noncoated group (20.3 ± 14.5%). Carmeda surface coating demonstrated some beneficial effects, but to a lesser degree than the albumin.

Oxygenator

Membrane oxygenator

10.1177/026765919901400307

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Citations (43)