Preliminary validity of a computer-based test of everyday function (Virtual Kitchen Challenge [VKC]) was examined against brain-imaging markers of cerebrovascular disease and in contrast to conventional neuropsychological and self-report measures. Twenty community-dwelling older adults (
Extraskeletal osteosarcoma (EO) is a soft tissue sarcoma characterized by the production of bone matrix by neoplastic cells. Benign osteoid in EO, leading to a diagnostic dilemma, is rarely encountered. Herein, for the first time, we present a case with cytogenetically confirmed EO combined with or preceding myositis ossificans (MO). A 21-year-old man had a mildly painful swelling in his left knee. Imaging studies demonstrated a 39-mm mass with peripheral mineralization and cystic change on the posterolateral side of the left fibular head. He was clinically suspected of having either MO or a malignancy, such that wide resection was performed. Macroscopically, the mass was grayish to brown. In the cut section, multiple cystic lesions in addition to solid components were noted. Histopathologically, the solid components demonstrated diffuse proliferation of pleomorphic tumor cells with osteoclast-like giant cells. The malignant tumor cells formed osteoid. In the periphery, the mass was benign, showing mature bone tissue and focally non-malignant woven bone with fibroblasts, compatible with zonation. Fluorescence in situ hybridization (FISH) demonstrated split signals of the USP6 gene. These findings suggested EO with preceding MO. Although the pathogenesis remains to be elucidated, the observed USP6 rearrangement might contribute to both the diagnosis of EO with preceding MO and an understanding of the underlying histopathology.
Tumor necrosis factor-alpha (TNF-alpha) is present in human placental and uterine cells at the early and late stages of gestation and promotes the regulation of trophoblast growth and invasion. We evaluated whether TNF-alpha levels in the placenta and blood of pre-eclamptic women differed from those with normal pregnancies.The subjects were 39 pregnant women carrying single fetuses (21 normal-pregnant and 18 pre-eclamptic patients). Their average gestational age at entry was 38-39 weeks. Peripheral blood was collected before the onset of labor and separated serum was stored at -20 degrees C. A tissue segment of the placenta was cut and frozen in liquid nitrogen immediately after delivery at -80 degrees C. The frozen placental tissue was added to phosphate-buffered saline. The tissue was fully homogenized and centrifuged. Separated supernatant was stored at -80 degrees C. TNF-alpha levels in separated serum and TNF-alpha and total protein (TP) levels in separated supernatant were measured. The presence of TNF-alpha in the placenta was evaluated by immunohistochemistry in five pre-eclamptic and five normal-pregnant patients.Serum TNF-alpha levels were higher in pre-eclampsia than in normal pregnancies. However, TNF-alpha/TP levels in the placenta did not differ significantly between the two groups. As for TNF-alpha immunostaining of trophoblastic cells in the placenta, it was weak in three and moderate in two of the normal pregnancies, while it was absent in two, weak in one, and moderate in two in the pre-eclampsia group.We demonstrated no significant increase in TNF-alpha/TP levels in the placenta in pre-eclampsia despite a significant increase in serum TNF-alpha levels. There was no strong immunostaining for TNF-alpha detected by immunohistochemistry in the pre-eclampsia group. These findings suggest that TNF-alpha in the placenta is not a key cytokine to interfere with normal trophoblast invasion into the myometrium in pre-eclampsia, and that sources other than the placenta may contribute to the elevated levels of TNF-alpha found in the circulation of pre-eclamptic patients.
Case Reports| August 03 2011 Cytologic Features of Ovarian Granulosa Cell Tumor Metastatic to the Lung: A Case Report Subject Area: Pathology and Cell Biology Ken Shimizu; Ken Shimizu From the Department of Pathology, Dokkyo University School of Medicine and Dokkyo University School of Medicine Hospital, and Department of Obstetrics and Gynecology, Tochigi National Hospital, Tochigi, Japan Search for other works by this author on: This Site PubMed Google Scholar Takashi Yamada; Takashi Yamada From the Department of Pathology, Dokkyo University School of Medicine and Dokkyo University School of Medicine Hospital, and Department of Obstetrics and Gynecology, Tochigi National Hospital, Tochigi, Japan Search for other works by this author on: This Site PubMed Google Scholar Yoshihiko Ueda; Yoshihiko Ueda From the Department of Pathology, Dokkyo University School of Medicine and Dokkyo University School of Medicine Hospital, and Department of Obstetrics and Gynecology, Tochigi National Hospital, Tochigi, Japan Search for other works by this author on: This Site PubMed Google Scholar Takehiko Yamaguchi; Takehiko Yamaguchi From the Department of Pathology, Dokkyo University School of Medicine and Dokkyo University School of Medicine Hospital, and Department of Obstetrics and Gynecology, Tochigi National Hospital, Tochigi, Japan Search for other works by this author on: This Site PubMed Google Scholar Nobuhide Masawa; Nobuhide Masawa From the Department of Pathology, Dokkyo University School of Medicine and Dokkyo University School of Medicine Hospital, and Department of Obstetrics and Gynecology, Tochigi National Hospital, Tochigi, Japan Search for other works by this author on: This Site PubMed Google Scholar Toshihiko Hasegawa Toshihiko Hasegawa From the Department of Pathology, Dokkyo University School of Medicine and Dokkyo University School of Medicine Hospital, and Department of Obstetrics and Gynecology, Tochigi National Hospital, Tochigi, Japan Search for other works by this author on: This Site PubMed Google Scholar Acta Cytologica (1999) 43 (6): 1137–1141. https://doi.org/10.1159/000331367 Article history Published Online: August 03 2011 Content Tools Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Tools Icon Tools Get Permissions Cite Icon Cite Search Site Citation Ken Shimizu, Takashi Yamada, Yoshihiko Ueda, Takehiko Yamaguchi, Nobuhide Masawa, Toshihiko Hasegawa; Cytologic Features of Ovarian Granulosa Cell Tumor Metastatic to the Lung: A Case Report. Acta Cytologica 1 December 1999; 43 (6): 1137–1141. https://doi.org/10.1159/000331367 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsActa Cytologica Search Advanced Search Article PDF first page preview Close Modal Keywords: granulosa cell tumor, ovarian neoplasms, metastasis, lung neoplasms 1999Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. You do not currently have access to this content.
Background: Efficient, objective measures of mild functional difficulties are lacking. Preliminary data from a novel, non-immersive virtual reality, performance-based task (Virtual Kitchen Challenge; VKC) were obtained to address this gap.Methods: 14 older and 21 younger adults completed cognitive tests and two everyday tasks (breakfast, lunch) in the VKC with virtual objects and a touch-screen and in the Real Kitchen with real objects (order counterbalanced). Automated performance measures were obtained from the VKC program and human coders scored VKC and Real Kitchen videos for errors.Results: Older adults made more errors than younger adults on the VKC and Real Kitchen, with similar error patterns across measures. VKC automated measures were significantly related to measures from human coders, performance on the Real Kitchen, and cognitive test scores.Conclusion: The VKC is a valid and highly efficient performance-based measure of subtle functional difficulties with great potential for future clinical and research applications.
This paper describes the development of our virtual reality based rehabilitation system for children with cerebral palsy (CP). This system was designed to facilitate intrinsic motivation of CP patients for a rehabilitation exercise by integrating a gamification framework. In a previous study, we identified patient's strategy changes during the rehabilitation task involving catching. The aim of this study is to develop a data-mining framework that utilizes results from the previous study coupled with real-time visualization and data generation to further the understanding of the strategy changes during the catching task. In this paper, we describe a result of a preliminary development of the proposed framework.
