Ye Guo

Institute of Hematology & Blood Diseases Hospital

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Xiaofan Zhu

Institute of Hematology & Blood Diseases Hospital

Xiaojuan Chen

Xiangya Hospital Central South University

Wenyu Yang

Institute of Hematology & Blood Diseases Hospital

Yao Zou

Sichuan Agricultural University

Yang Wan

Institute of Hematology & Blood Diseases Hospital

Xiaolan Li

Sichuan University

Yumei Chen

Zhengzhou University

Li Zhang

University of California, San Francisco

Min Ruan

Chinese Academy of Medical Sciences & Peking Union Medical College

Tianfeng Liu

Huazhong University of Science and Technology

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Chinese Academy of Medical Sciences & Peking Union Medical College

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Institute of Hematology & Blood Diseases Hospital

Peking Union Medical College Hospital

Peking University

National Clinical Research

Academy of Medical Sciences

Sichuan University

Sun Yat-sen University

Shanghai Jiao Tong University

Central South University

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Author Correction: Dynamic forecasting of severe acute graft-versus- host disease after transplantation

Nature Computational Science (2022)

Xueou Liu Yigeng Cao Ye Guo Xiaowen Gong Yahui Feng

10.1038/s43588-022-00256-7

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Citations (0)

Seminal Plasma Metabolomics Signatures of Normosmic Congenital Hypogonadotropic Hypogonadism

SSRN Electronic Journal (2022)

Xiaogang li Ye Guo Xi Wang Haolong Li Jiangfeng Mao

Background: Normosmic congenital hypogonadotropic hypogonadism (nCHH) is a rare disease, whose pathogenesis remains unclear. Here, we conducted untargeted metabolomics and lipidomics to identify seminal plasma signatures of nCHH. Methods: Twenty-five diagnosed patients with nCHH (HH group) and twenty-three age-matched healthy controls (HC group) were enrolled. Seminal plasma samples, laboratory parameters and patientsâ€™ medical data were collected. Untargeted metabolomics and lipidomic profiling were performed using mass spectrometry (MS). Results: The metabolomics profiling are altered among patients with nCHH and healthy controls. There are 160 kinds of differential metabolites and the main different lipid species are TAG, PC, SM and PE. Conclusions The metabolomics profiles of patients with nCHH changed. To our knowledge, this is the first report of metabolomics profile in men with nCHH. We hope that this study may provide important insights into the pathophysiology of nCHH.Funding Information: This work was supported by the National Key Research and Development Program of China (2018YFE0207300), Beijing Municipal Science & Technology Commission (Z211100002521021). This work is supported by Beijing Key Clinical Specialty for Laboratory Medicine - Excellent Project (No. ZK201000).Conflict of Interests: The authors declare that they have no competing interests.Ethical Approval: Patient biospecimens were collected and approved by institutional committee that protects human subjects from PUMCH. Consent has been obtained from each patient or subject after full explanation of the purpose and nature of all procedures used.

Kallmann syndrome

10.2139/ssrn.4227597

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Citations (1)

Efficacy and prognostic assessment of chemotherapy-bridged transplantation in pediatric patients with advanced myelodysplastic syndromes

Bone Marrow Transplantation (2024)

Xingchen Wang Chenmeng Liu Yunlong Chen Yang Wan Wenbin An

10.1038/s41409-024-02488-9

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Correlation Analysis of Initial Methylation Stratification and Clinical Characteristics in Juvenile Myelomonocytic Leukemia

Blood (2022)

Wenyu Yang Chenmeng Liu Xiaolan Li Lipeng Liu Fang Liu

Juvenile myelomonocytic leukemia

Stratification (seeds)

10.1182/blood-2022-166110

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Clinical Characteristics and Stratified Analysis of Ph-like Acute Lymphoblastic Leukemia in Children: A Retrospective Study from China

Blood (2022)

Xiaoyan Zhang Xiaofan Zhu Xiaojuan Chen Wenyu Yang Ye Guo

Acute lymphocytic leukemia

Hematologic Neoplasms

10.1182/blood-2022-166291

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Clinical-biological Characteristics and Poor Predictive Value of Early Treatment Response in Pediatric Acute Lymphoblastic Leukemia with CDKN2A Gene Deletion Treat with CCLG-ALL 2015 protocol

Authorea (Authorea) (2020)

jing feng Ye Guo Yang Wen Yao Zou Xiaofan Zhu

Background: Deletion of cyclin-dependent kinase inhibitor 2A (CDKN2A) is prevalent in pediatric acute lymphoblastic leukemia (ALL) and the prognostic importance of CDKN2A deletion is still controversial. Procedure: A total of newly diagnosed 655 pediatric ALL cases were treated with Chinese Children’s Leukemia Group-acute lymphoblastic leukemia 2015 (CCLG-ALL 2015) protocol[1]. We investigated the difference among B-ALL and T-ALL patients with CDKN2A deletion for clinical characteristics at diagnosis, immunophenotype, risk stratification, cytogenetic risk group, and early treatment responses.We also analyzed the prognostic markers for event-free survival(EFS) in CDKN2A-deleted patients. Result: The incidence of CDKN2A gene deletion was presented in 14.6% (87/595) of B-ALL subgroup and 40.0% (24/60) of T-ALL subgroup. T-ALL subgroup was characterized by a higher male/female ratio, a higher proportion of older children (>10 years old) and WBC counts of greater than 50x109/L compared to B-ALL(P<0.05). In the univariate analysis, CNS 2, cytogenetic risk groups, prednisone poor responders (PPR), poor early response (PER), and MRD≥0.01% at day 46 (P<0.05) were associated with a poor event-free survival. Multivariable analysis revealed that PPR and MRD≥0.01% at day 46 were independent inferior prognostic factors for event-free survival(P<0.05). Conclusions: The incidence of CDKN2A deletion was more prevalent in T-ALL. CDKN2A deletion was significantly more prevalent in older (>10 years old) boys with leukocyte counts of greater than 50x109/L among T-ALL. PPR and MRD≥0.01% at day 46 were an independent prognostic factor for EFS in pediatric CDKN2A-deleted ALL.

Univariate analysis

Acute lymphocytic leukemia

10.22541/au.159050316.63725074

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Establishment and development of the personalized criteria for microscopic review following multiple automated routine urinalysis systems

Clinica Chimica Acta (2015)

Juan Du Jia Xu Fei Wang Ye Guo Feng Zhang

Reference range

Reference values

10.1016/j.cca.2015.02.022

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Citations (19)

Safety and Efficacy of Olverembatinib (HQP1351) Combined with Lisaftoclax (APG-2575) in Children and Adolescents with Relapsed/Refractory Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (R/R Ph+ ALL): First Report from a Phase 1 Study

Blood (2024)

Jingliao Zhang J. Wang Huanshan Guo Tianfeng Liu Xiaoyan Zhang

Refractory (planetary science)

Philadelphia chromosome

Acute lymphocytic leukemia

10.1182/blood-2024-207035

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Quality assurance on semen routine analysis

Chin J Clin Lab Mgt (Electronic Edition) (2017)

Ye Guo Wei Cui

Semen analysis is an important laboratory indicator for the diagnosis and monitoring of male genitourinary diseases. Heterogeneity and many other factors contribute to the differences in semen analysis. According to specimen characteristics, we should focus on the specimen processing including specimen collection/handling, liquefaction, incubation temperature, internal quality control, external quality assessment, and test report to provide the correct semen analysis report to help clinicians. Key words: Semen analysis; Quality control

Semen Analysis

Semen collection

10.3877/cma.j.issn.2095-5820.2017.02.002

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Short-Term Follow-up of Blinatumomab in Children with B-Cell Precursor Acute Lymphoblastic Leukemia：Study of a Single Center from China

Blood (2022)

Wenyu Yang Xiaolan Li Lipeng Liu Yang Wan Tianfeng Liu

Blinatumomab

Single Center

Acute lymphocytic leukemia

Center (category theory)

10.1182/blood-2022-164642

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