P.R. Hein

Radboud University Nijmegen

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H.W. Jongsma

Radboud University Nijmegen

T.K.A.B. Eskes

Radboud University Nijmegen

Eric A.P. Steegers

Erasmus MC - Sophia Children’s Hospital

J.T. Braaksma

Vrije Universiteit Amsterdam

J. Janssens

University of Bari Aldo Moro

Adriaan C.I.T.L. Tan

Canisius-Wilhelmina Ziekenhuis

Jan Sporken

Canisius-Wilhelmina Ziekenhuis

Jules Fast

Ziekenhuis Groep Twente

L.A.M. Stolte

Vrije Universiteit Amsterdam

H. P. J. M. van Lakwijk

Radboud University Nijmegen

Cooperative Institutions

Radboud University Nijmegen

Centro de Investigación en Red en Enfermedades Cardiovasculares

Inserm

Centro de Investigación Biomédica en Red

Institute of Cardiology

Istituti di Ricovero e Cura a Carattere Scientifico

University Medical Center Utrecht

University Medical Center

Maastricht University

Erasmus MC

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A case of acardiac anomaly in the cynomolgus monkey (Macaca fascicularis): a complication of monozygotic monochorial twinning.

PubMed (1985)

P.R. Hein Johan C. Van Groeninghen J.J.G. Puts

A case of acardius acephalus in a Macaca fascicularis is reported. This congenital anomaly occurs only in multiple-birth gestations (most commonly monozygotic twins). Artery-to-artery and vein-to-vein anastomoses appear to be a constant feature. This condition is very rare in man and probably even more so in monkeys. Classification and theories on etiology are discussed.

Etiology

Anomaly (physics)

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Citations (8)

Effects of dietary sodium restriction and posture on plasma levels of atrial natriuretic peptide, aldosterone and free aldosterone in normal human pregnancy

Journal of Endocrinology (1990)

EAP Steegers Th. J. Benraad H.W. Jongsma Adriaan C.I.T.L. Tan P.R. Hein

ABSTRACT The effects of dietary sodium restriction and posture on plasma concentrations of atrial natriuretic peptide (ANP), aldosterone and free aldosterone were investigated in ten women between weeks 29 and 33 of normal pregnancy. Hormone levels were studied during unrestricted sodium intake and on day 6 of a low sodium diet. On both occasions venous blood was obtained in the sitting as well as in the left lateral tilt position. Plasma concentrations of ANP during the unrestricted sodium intake were not raised compared with control values in healthy non-pregnant females. Recovery experiments showed no differences in the degradation of ANP in blood from pregnant and non-pregnant women. Plasma concentrations of ANP significantly decreased (by 32%) in response to the low sodium regime in both positions. Concentrations of aldosterone and free aldosterone (in women in the sitting position) increased twofold after sodium restriction. Mean values of ANP were higher in women in the left lateral tilt position that in those in the sitting position, but the difference was not significant. Concentrations of aldosterone and free aldosterone were significantly lower (by around 30%) in women in the left lateral tilt position compared with those in the sitting posture. Journal of Endocrinology (1990) 124, 507–513

Atrial natriuretic peptide

10.1677/joe.0.1240507

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Citations (25)

The influence of maternal exercise on the uteroplacental vascular bed resistance and the fetal heart rate during normal pregnancy

European Journal of Obstetrics & Gynecology and Reproductive Biology (1988)

Eric A.P. Steegers Gerba Buunk R. A. Binkhorst H.W. Jongsma P.F.F. Wijn

Doppler ultrasound

Pulsatility index

10.1016/s0028-2243(88)80006-6

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Citations (27)

Hypertension and pregnancy

Elsevier eBooks (1985)

Chester B. Martin P.R. Hein

10.1016/b978-0-407-02301-7.50009-4

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Citations (7)

One-year morbidity in very premature infants: prognostic value of duration of pregnancy, birthweight and neonatal morbidity

European Journal of Obstetrics & Gynecology and Reproductive Biology (1985)

Jan Sporken P.R. Hein J.M. Boon

10.1016/0028-2243(85)90142-x

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Citations (3)

A Study of maternal ecg characteristics before and during intravenous tocolysis with β‐sympathicomimetics

Acta Obstetricia Et Gynecologica Scandinavica (1987)

Léon G.M. Mulders G. H. J. Boers M. M.J.F. Prickartz‐Wijdeveld P.R. Hein

Severe maternal complications during beta-mimetic therapy have been reported. In a study of maternal complications related to intravenous tocolysis, which covering a period of 2 years, we paid special attention to the maternal ECG before and during treatment. There was a high prevalence of pretreatment ECG changes: tachycardia (23.6%), disorders of impulse conduction (43.6%), ST-depression (14.5%) and disorders of repolarization (43.6%). During intravenous beta-mimetic therapy there was an increase in the prevalence of tachycardia, prolonged QT-time and disorders of repolarization. We also studied the course in time of the different ECG characteristics during treatment. With regard to the ST-depression, a possible physiological adaptation to the beta-mimetic drug is described. We could not find this possible adaptation with regard to the other ECG characteristics. None of the women in the studied group showed clinical signs of myocardial ischemia, notwithstanding the high prevalence of ECG changes. We conclude that the ECG criteria for discontinuation of tocolytic therapy need re-evaluation.

Discontinuation

ST depression

Premature atrial contraction

Depression

10.3109/00016348709022045

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Citations (3)

Dietary sodium restriction during pregnancy; a historical review

European Journal of Obstetrics & Gynecology and Reproductive Biology (1991)

Eric A.P. Steegers T.K.A.B. Eskes H.W. Jongsma P.R. Hein

Intrauterine growth restriction

Growth restriction

10.1016/0028-2243(91)90097-5

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Citations (38)

(Patho)physiological implications of chronic dietary sodium restriction during pregnancy; a longitudinal prospective randomized study

BJOG An International Journal of Obstetrics & Gynaecology (1991)

Eric A.P. Steegers H. P. J. M. VAN LAKWIJK H.W. Jongsma Jules Fast T de Boo

Abstract Objective— To study the possible pathophysiological implications of long continued dietary sodium restriction in pregnancy. Design— Longitudinal prospective randomized study of the effects of a low sodium diet compared with unrestricted sodium intake in pregnancy. Setting— Academic Department of Obstetrics and Gynaecology at Sint Radboud Hospital, Nijmegen, The Netherlands. Subjects— 42 healthy nulliparous women. Intervention— A low sodium diet (20 mmol sodium daily) started in the 14th week of pregnancy and stopped after delivery. Main outcome measures— Maternal weight gain, food intake, blood pressure, cardiac output, systemic vascular resistance, haematocrit and birthweight. Results— Total maternal weight gain and dietary energy intake during pregnancy and weight at 1 and 6 weeks postpartum were significantly lower in the low sodium group. Blood pressure during pregnancy did not show major differences. Stroke volume and cardiac output during pregnancy were significantly lower in the low sodium group whereas systemic vascular resistance was significantly higher. Haematocrit values in the low sodium group tended to be lower during pregnancy, but were significantly lower at 1 and 6 weeks postpartum than in the unrestricted group. Placental and birthweights were not significantly different between the two groups. Conclusions— Chronic dietary sodium restriction during pregnancy is characterized by a diminished body fat accumulation and a reduction in circulating volume, due to a decrease in both plasma and red cell volume, in combination with a high systemic vascular resistance without major effects on blood pressure and birthweight.

Intrauterine growth restriction

Low sodium diet

10.1111/j.1471-0528.1991.tb15335.x

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Citations (51)

The effect of chronic methadone treatment on intra-uterine growth of the Cynomolgus monkey (Macaca fascicularis)

European Journal of Obstetrics & Gynecology and Reproductive Biology (1988)

P.R. Hein J.S.J.O. Schatorjé H.J.A.A.M. Frencken

Dose

Heroin addiction

Methadone maintenance

10.1016/s0028-2243(88)80014-5