T. Rizzo

Valley Medical Center

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Co-Authors

Iraci Lucena da Silva Torres

EsSALUD

Isabel Cristina de Macedo

Hospital de Clínicas de Porto Alegre

Eva Havrdová

Charles University

Carla de Oliveira

Centro Universitário de Sete Lagoas

Wolnei Caumo

Hospital de Clínicas de Porto Alegre

Vanessa Leal Scarabelot

Universidade Federal do Rio Grande do Sul

Deepak L. Bhatt

Mount Sinai Health System

E. B. Savage

University of Kentucky

GW Stone

University of California, Los Angeles

Robert P. Giugliano

Thrombolysis in Myocardial Infarction Study Group

Cooperative Institutions

Harvard University

Universidade Federal do Rio Grande do Sul

Hospital de Clínicas de Porto Alegre

Brigham and Women's Hospital

Inserm

Duke University

Assistance Publique – Hôpitaux de Paris

Icahn School of Medicine at Mount Sinai

University of Pennsylvania

Massachusetts General Hospital

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Hypertrophic Obesity is Associated with Inflammation and Insulin Resistance

MD Conference Express (2013)

T. Rizzo Ulf Smith

Obesity causes changes in adipose tissue, the liver, and skeletal muscle that lead to systemic inflammation and insulin resistance. Obese individuals who have the ability to recruit new adipocytes develop adipocyte hyperplasia, whereas others have adipocyte hypertrophy due to impaired adipogenesis. The ability to recruit new adipocytes protects against ectopic fat accumulation in the abdomen, skeletal muscle, and liver.

10.1177/155989771316008

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Efeito do uso da anestesia na aplicação de Acupuntura (AC) em ratos submetidos ao modelo de dor neuropática (DN)

Lauren Naomi Spezia Adachi Carla de Oliveira Rafael Vercelino Vanessa Leal Scarabelot T. Rizzo

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MD Conference Express (2013)

T. Rizzo Indulis Kumsārs

Bifurcation lesions occur at the point where one coronary artery branches from another. Currently, provisional side-branch stenting is the preferred strategy for treating most bifurcation lesions. This type of stenting involves stenting the main branch, reserving further stent placement in the side branch only if it is compromised. However, it is not known if provisional stenting provides the best outcomes in bifurcation lesions involving a large side branch. The aim of the Nordic-Baltic Bifurcation Study IV [NCT01496638] was to compare provisional stenting with a two-stent techniques for the treatment of true coronary bifurcation lesions involving a large side branch.

Main branch

10.1177/155989771319005

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New Treatments Significantly Improve Responses in Patients With Plaque Psoriasis

MD Conference Express (2015)

T. Rizzo Mark Lebwohl Kristian Reich Richard Langley Ken Gordon

10.1177/1559897715584579

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Higher Risk of Aortic Complications in GCA Patients with Positive PET

MD Conference Express (2014)

T. Rizzo Hubert de Boysson

Aortic complications are an important cause of death in patients with giant-cell arteritis (GCA). Extracranial involvement of large vessels in patients with GCA probably is underdiagnosed. 18-fluoro-deoxyglucose (FDG) positron emission tomography (PET) offers good sensitivity for the detection of large vessel involvement in patients with GCA [Blockmans D et al. Arthritis Rheum 2006; Besson FL et al. Eur J Nucl Med Mol Imaging 2011]. The objectives of this study were to characterize large vessel involvement using PET in a cohort of patients with GCA, describe the patients who had aortic complications, and identify factors associated with aortic complications.

Aortitis

Arteritis

10.1177/155989771417006

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Oversupply of Free Fatty Acids to the Systemic Circulation is Not a Distinct Feature of Insulin Resistance or Obesity

MD Conference Express (2013)

T. Rizzo Fredrik Karpe

Measurements of free fatty acid (FFA), also known to as non-esterified fatty acid, and glucose kinetics have shown that obese individuals have adipose tissue that is insulin resistant [Jensen MD, Nielsen S. Metabolism 2007]. It is commonly thought that oversupply of FFA is a major contributor to the development of insulin resistance in obesity. This article discusses the known molecular mechanisms for the phenomenon of insulin resistance in adipose tissue and challenged the notion of oversupply of FFA in obesity.

Systemic circulation

10.1177/155989771316009

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Dabigatran Inferior to Warfarin in Patients with Mechanical Heart Valves

MD Conference Express (2013)

T. Rizzo Frans Van de Werf

Preclinical studies in porcine mechanical heart valve models suggested that dabigatran may effectively prevent valve thrombosis [Schomburg JL et al. J Invest Surg 2012]. These results led to A Randomized, Phase 2 Study to Evaluate the Safety and Pharmacokinetics of Oral Dabigatran Etexilate in Patients After Heart Valve Replacement [RE-ALIGN; Eikelboom JW et al. N Engl J Med 2013]. The aim of the RE-ALIGN trial was to evaluate a dosing algorithm of dabigatran based on the RE-LY study to prevent thromboembolic complications in patients with mechanical heart valve replacement.

Mechanical heart

Mechanical heart-valve

10.1177/155989771315003

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Safety and Efficacy of Anticoagulants

MD Conference Express (2012)

T. Rizzo Gregory C. Flaker

Apixaban is an oral factor Xa inhibitor with prompt onset and offset of anticoagulation, twice-a-day dosing, and no need for coagulation monitoring. This article discusses the efficacy and safety of apixaban compared with warfarin in ARISTOTLE trial, and with aspirin in AVERROES Trial. This article also discusses the challenge of choosing anticoagulation therapy for patients with AF using the RE-LY, ROCKET, ARISTOTLE, and ENGAGE AF-TIMI 48 as examples.

Apixaban

10.1177/155989771206013

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DBS Improves FOG in Patients with PD

MD Conference Express (2014)

T. Rizzo Michael T. Barbe

High-frequency deep brain stimulation (DBS) is effective for relief of Parkinson's disease (PD) symptoms. However, studies on the effect of subthalamic nucleus DBS (STN-DBS) on freezing of gait (FOG) have reported inconsistent results, with some suggesting that STN-DBS alleviates FOG [Davis JT et al. Clin Neurol Neurosurg 2006] and others reporting worsening of gait and balance [van Neunen BFL et al. Mov Disord 2008; Krack P et al. N Engl J Med 2003]. This article discusses the the Vercise Implantable Stimulator for Treating Parkinson's Disease trial [VANTAGE; NCT01221948].

Subthalamic Nucleus

Motor symptoms

10.1177/155989771415005

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Prehospital Bivalirudin Improved Outcomes versus Heparin in Patients with Myocardial Infarction

MD Conference Express (2013)

T. Rizzo Philippe Gabríel Steg

The HORIZONS AMI trial showed that bivalirudin therapy in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous intervention (PCI) reduced mortality and bleeding for up to 3 years compared with heparin plus a glycoprotein IIb/IIIa inhibitor [Stone GW et al. N Engl J Med 2008]. However, according to the results of the European Ambulance Acute Coronary Syndrome Angiography Trial [EUROMAX; Steg PG et al. N Engl J Med 2013], several issues remain. The objective of the EUROMAX trial was to examine whether bivalirudin, initiated in patients with STEMI while being transported in the ambulance for primary PCI, was superior to heparin and provisional use of glycoprotein IIb/IIIa inhibitors.

Bivalirudin

10.1177/155989771319004

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