L. Iske

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Rainer Laufs

Institut für Hygiene und Umwelt

G Oehler

Vitality Institute

Bernhard Zöllner

BioScientia (Poland)

Susanne Polywka

Universität Hamburg

H. A. Martens

Sint Maartenskliniek

H.-H. Feucht

Zentrum für Labormedizin

H Koch

University of Freiburg

Feucht Hh

Universität Hamburg

H. Feucht

Institut für Medizinische Informatik, Biometrie und Epidemiologie

Hans‐Jürgen Stellbrink

Infektionsmedizinisches Centrum Hamburg

Cooperative Institutions

Universität Hamburg

University Medical Center Hamburg-Eppendorf

Eppendorf (Germany)

Institut für Medizinische Informatik, Biometrie und Epidemiologie

Infektionsmedizinisches Centrum Hamburg

Vitality Institute

Mammazentrum Hamburg

University of Göttingen

Klinik und Poliklinik für Nuklearmedizin

Martin Luther University Halle-Wittenberg

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Prognostic significance of the hepatitis B virus-DNA concentration in patients after orthotopic liver transplantation.

PubMed (1994)

Bernhard Zöllner Susanne Polywka Feucht Hh H. A. Martens L. Iske

Hepatitis B virus-DNA was detected by polymerase chain reaction in 9 out of 10 patients after orthotopic liver transplantation. Three of these patients were at the same time positive for hepatitis B virus-DNA by dot-blot hybridization (hepatitis B virus-DNA > 1.5 pg/ml). In these three patients HBs-antigen (HBsAg) reappeared within a mean time of 12 weeks after orthotopic liver transplantation (range 7-18 weeks). Only two of the six polymerase chain reaction-positive and dot-blot-negative patients (hepatitis B virus-DNA between 0.4 fg/ml and 1.5 pg/ml) had recurrence of HBsAg within a mean time of 54 weeks (range 52-56 weeks). Passive immunoprophylaxis with anti-HBs antibodies (serum titers > 100 IU/l) did not prevent infection of the graft in the five reinfected patients. We conclude that a low concentration of serum hepatitis B virus-DNA after orthotopic liver transplantation, which is detectable only by polymerase chain reaction, indicates a delayed infection of the graft.

Dot blot

Hepatitis B

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Close correlation between hepatitis C virus serology and polymerase chain reaction in chronically infected patients

Infection (1992)

Darlene Reuter Susanne Polywka H. Feucht Rainer Laufs L. Iske

Hepatitis C

10.1007/bf01710675

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Citations (18)