Yu-Chi Gao

Guangdong Medical College

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Jun-Fa Xu

Guangdong Medical College

You-Chao Dai

Guangdong Medical College

Jun-Ai Zhang

Guangdong Medical College

Shi-Yan Yu

Guangdong Medical College

Yan Jia

Maternal and Child Health Hospital of Sichuan Province

Xiaoxia Fu

Shijiazhuang University

Yuan-Bin Lu

Eighth Affiliated Hospital of Sun Yat-sen University

Jixin Zhong

Huazhong University of Science and Technology

Zheng W. Chen

University of Illinois Urbana-Champaign

Wan-Dang Wang

University of Illinois Urbana-Champaign

Cooperative Institutions

Guangdong Medical College

Key Laboratory of Guangdong Province

Dongguan People’s Hospital

Anhui Medical University

Chinese Academy of Sciences

University of Illinois Urbana-Champaign

Illinois College

University of Illinois Chicago

Chinese Academy of Medical Sciences & Peking Union Medical College

Hainan University

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BTLA-expressing CD11c antigen presenting cells in patients with active tuberculosis exhibit low capacity to stimulate T cell proliferation

Cellular Immunology (2016)

Wan-Dang Wang Yu-Chi Gao Yuan-Bin Lu Jun-Ai Zhang Gan-Bin Liu

BTLA

CD11c

CD86

ESAT-6

10.1016/j.cellimm.2016.09.015

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Citations (21)

Profiling dendritic cell subsets in the patients with active pulmonary tuberculosis

Molecular Immunology (2017)

Yuan-Bin Lu De-Qian Xiao Kui-Di Liang Jun-Ai Zhang Wan-Dang Wang

CD86

CD80

Plasmacytoid dendritic cell

10.1016/j.molimm.2017.08.007

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Citations (13)

IL-6 Inhibition Reduces STAT3 Activation and Enhances the Antitumor Effect of Carboplatin

Mediators of Inflammation (2016)

Zhiyong Wang Jun-Ai Zhang Xian-Jin Wu Yan-Fang Liang Yuan-Bin Lu

Recent studies suggest that tumor-associated macrophage-produced IL-6 is an important mediator within the tumor microenvironment that promotes tumor growth. The activation of IL-6/STAT3 axis has been associated with chemoresistance and poor prognosis of a variety of cancers including colorectal carcinoma and thus serves as a potential immunotherapeutic target for cancer treatment. However, it is not fully understood whether anticytokine therapy could reverse chemosensitivity and enhance the suppressive effect of chemotherapy on tumor growth. In this study, we aimed to investigate the effect of IL-6 inhibition therapy on the antitumor effect of carboplatin. Enhanced expression of IL-6 and activation of STAT3 were observed in human colorectal carcinoma samples compared to normal colorectal tissue, with higher levels of IL-6/STAT3 in low grade carcinomas. Treatment of carboplatin (CBP) dose-dependently increased IL-6 production and STAT3 activation in human colorectal LoVo cells. Blockade of IL-6 with neutralizing antibody enhanced chemosensitivity of LoVo cells to carboplatin as evidenced by increased cell apoptosis. IL-6 blockade abolished carboplatin-induced STAT3 activation. IL-6 blockade and carboplatin synergistically reduced cyclin D1 expression and enhanced caspase-3 activity in LoVo cells. Our results suggest that inhibition of IL-6 may enhance chemosensitivity of colon cancers with overactive STAT3 to platinum agents.

Carboplatin

10.1155/2016/8026494

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Citations (16)

Tuberculosis-sensitized monocytes sustain immune response of interleukin-37

Molecular Immunology (2016)

Jun-Ai Zhang Gan-Bin Liu Bi-Ying Zheng Yuan-Bin Lu Yu-Chi Gao

Proinflammatory cytokine

Monocyte

10.1016/j.molimm.2016.09.018

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Citations (7)