Naoki Ishiwa

Kanagawa Cardiovascular and Respiratory Center

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Yoshikazu Noguchi

Ajinomoto (United States)

Takamitsu Maehara

Yokohama Minami Kyosai Hospital

Takaki Yoshikawa

Kanagawa Prefectural Hospital Organization

Yuji Yamamoto

Osaka University

Yoshinori Takanashi

Chiba University

Soichiro Morinaga

Kanagawa Prefectural Hospital Organization

Nobuo Ogawa

Lawrence Berkeley National Laboratory

Michihiko Tajiri

National Institutes for Quantum and Radiological Science and Technology

Yasushi Rino

Yokohama City University

Toshio Imada

Chigasaki Rehabilitation College

Cooperative Institutions

Yokohama City University

Kanagawa Prefectural Hospital Organization

Kanagawa Cancer Center

Yokohama City University Medical Center

Yokohama City University Hospital

Osaka University

Kanagawa Cardiovascular and Respiratory Center

The University of Tokyo

Nagoya University

National Cancer Center Hospital East

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High cyclin E and low p27/Kip1 expressions are potentially poor prognostic factors in lung adenocarcinoma patients

Lung Cancer (2001)

Hiroyuki Hayashi Nobuo Ogawa Naoki Ishiwa Takuya Yazawa Yoshiaki Inayama

Cyclin E

Cyclin A

Cyclin B

Cyclin D

10.1016/s0169-5002(01)00211-2

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Citations (56)

A case of malignant mesotheloma obtaining the fifth grade after extrapleural pneumonectomy

The Journal of the Japanese Association for Chest Surgery (2006)

Yoshihiro Suzuki Haruhiko Ishii Naoki Ishiwa Nobuo Ogawa Hiroyuki Ito

malignant mesotheliomaは一般に予後不良であり根治が困難である．われわれは胸膜肺全切除術を施行し5年生存が得られた症例を経験したので報告する．症例は52歳女性．主訴は右胸痛．アスベストの暴露歴はなし．1998年12月，上記主訴で前医を受診し右胸水貯留を認め，1999年1月，胸腔鏡下胸膜生検施行した．その結果malignant mesothelioma in situと診断され，当センターにて諸検査で手術可能と判断し，1999年3月3日，右胸膜肺全切除術を施行した．術後病理診断はmalignant mesothelioma, T2N0M0 stage I（IMIGによるTNM Classification）であった．術後経過も良好で，術後6年になるが無再発生存中である．malignant mesotheliomaの根治には早期診断が不可欠である．よって原因不明の胸水を診た場合には積極的に胸腔鏡下胸膜生検を施行し診断をつけるべきであると考える．またin situ の状態は胸膜肺全切除術による腫瘍の完全切除による根治が期待できる．

Extrapleural Pneumonectomy

10.2995/jacsurg.20.773

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[Repeated pneumonia in the middle lobe caused by congenital bronchoesophageal fistula].

PubMed (1996)

Atsuto Yoshizawa Nobuyuki Kobayashi Koichiro Kudo Junzaburo Kabe Naoki Ishiwa

A 52-year-old woman was admitted to our hospital because of repeated episodes of pneumonia in the middle lobe. She had also experienced coughing during meals. The history and chest CT findings suggested the presence of a bronchoesophageal fistula. An upper GI series revealed a fistula between an esophageal diverticulum and the superior segment bronchus of the right lower lobe. Fiberoptic bronchoscopy done immediately after the upper GI series revealed barium sulfate leaking from the superior segment bronchus of the right lower lobe into the middle lobe bronchus. These findings indicated that the repeated pneumonia in the middle lobe was caused by a congenital bronchoesophageal fistula. Examination of the resected fistula showed that it was a Braimbridge type I bronchoesophageal fistula. Although of at least 49 cases of congenital bronchoesophageal fistulas with esophageal diverticula have been reported in the Japanese medical literature, we know of no previous case in which such a fistula was associated with middle-lobe pneumonia.

Right Main Bronchus

Lobe

Aspiration Pneumonia

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A Case of Gastric Endocrine Cell Carcinoma with Intramural Metastasis Invading Mainly the Muscle Layer

The Japanese Journal of Gastroenterological Surgery (2005)

Takaki Yoshikawa Kohei Ando A Shotsu Naoki Ishiwa Soichiro Morinaga

症例は58歳の女性で, 食思不振を主訴に来院した. 上部消化管内視鏡検査にて胃前庭部前壁に2型胃癌を, 幽門輪口側大彎に粘膜下腫瘍を認めた. 2003年10月, 幽門側胃切除D3郭清術を施行した. 組織学的所見では, Chromogranin A, Synaptophysin陽性の胃内分泌細胞癌を認めた. MP, N3, ly2, v3であった. 幽門輪口側大彎の粘膜下腫瘍には, 筋層を主座とし漿膜下層にかけて増殖する内分泌細胞癌を認めた. 主病巣との連続性を認めず, 内分泌細胞癌の壁内転移と判断した. 胃内分泌細胞癌は悪性度の高いまれな疾患である. 今回我々は, 胃内分泌細胞癌が, 筋層を主座とする壁内転移を来したまれな1例を経験した.内分泌細胞癌のように悪性度の高い胃癌では, 特異な形態を有する胃壁内転移を来す可能性があることが示唆された.

Chromogranin A

Synaptophysin

Enteroendocrine cell

Gastric carcinoma

10.5833/jjgs.38.141

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Citations (1)

[A case of Salmonella osteomyelitis of the rib].

PubMed (1994)

Naoki Ishiwa Nobufusa Aoyama Tsuyoshi Miyazaki Kazuhiko Iijima Thaís Sumie Nozu Imada

Salmonella osteomyelitis is a rare disease occurring at a frequency of less than 1% of all cases of osteomyelitis, we report a case of salmonella osteomyelitis of the rib, which was hard to differentiate from chest wall tumor. A 40-year-old man without gastrointestinal symptoms was admitted to our hospital for swelling of the right mammary region. It was suggestive of inflammatory pseudotumor because the swelling diminished, and we could not establish a diagnosis of abscess by scintigraphy with gallium-67 or by computed tomogram (CT). Drainage was carried out in the chest and about 10 ml of pus was removed. A culture was taken from the pus, revealing salmonella enteritidis, he was treated by local wound care and ABPC (aminobenzyl-penicillin). The open wound became sterile in 40 days, and was closed 46 days after being opened for drainage.

Sternum

Salmonella enteritidis

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Pleural lavage cytology at thoracotomy in patients with lung cancer.

The Journal of the Japanese Association for Chest Surgery (2000)

Naoki Ishiwa Takamitsu Maehara Haruhiko Nakayama Atsushi Fujita Tatsushi Yamagata

原発性肺癌の手術開胸時に胸腔内洗浄液の細胞診を施行し, その臨床的意義を検討した.治癒切除が行われた原発性非小細胞性肺癌352例中, 洗浄細胞診陽性例は26例 (7.4%) であった.組織型では腺癌に多く, 病理病期ではIII A期が最多であった.細胞診陽性例は胸膜浸潤陽性例に有意に多かったが, p0の症例も7例認められた.また細胞診陽性例はリンパ管侵襲陽性 (ly (+)) の症例に有意に多く, 1y因子との関連性が認められた.細胞診陽性例は5年生存率30 .2%で, 陰性例61.4%よりも有意に予後不良であり, 再発した17例中, 胸水再発は2例のみであった.以上の結果より, 洗浄細胞診陽性は癌の局所浸潤と考えるよりも, microscopic metastasisと考えるべき予後不良因子であり, 局所療法は有効ではないことが示唆された.

Thoracotomy

10.2995/jacsurg.14.9

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Citations (2)

Tuberculous aortitis, ruptured 48 years after therapeutic implantation of synthetic balls.

PubMed (2002)

Akihiro Matsumoto Yoshitaka Noguchi Naoki Ishiwa Yoji Yamamoto Shohei Yoshida

A case of tuberculous aortitis, ruptured 48 years after an implantation of synthetic balls into the extrapleural space was reported. Those balls were implanted as a therapeutic alternative to artificial pneumothorax for treating pulmonary tuberculosis. Free perforation was triggered by debridement of an expanding cold abscess. A tuberculous abscess adjacent to the arterial wall should be carefully managed even in the absence of the blood flow by image analysis.

Aortitis

Debridement (dental)

Perforation

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Citations (5)

P-883 Surgical approach for second primary lung cancer

Lung Cancer (2005)

Naoki Ishiwa Naoki Ogawa Hiroshi Ishii Yasushi Suzuki T Hashizume

Primary (astronomy)

Primary cancer

10.1016/s0169-5002(05)81376-5