P Pascotto

Ospedale di Mirano

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i-10 index

Research Trends

Author Order

Document Type

Co-Authors

E Piccolo

Universidad Nacional de La Matanza

D D’Este

Ospedale di Mirano

L Artusi

Associazione Nazionale Medici Cardiologi Ospedalieri

R. Cazzin

Associazione Nazionale Medici Cardiologi Ospedalieri

F Sartori

Instituto Cardiovascular de Buenos Aires

Emanuele Bertaglia

University of Padua

Pietro Delise

Casa di Cura Villa Garda

G Totaro

A Raviele

Bristol-Myers Squibb (United States)

Roberto Mantovan

Azienda ULSS 9 TREVISO

Cooperative Institutions

Ospedale di Mirano

University of Padua

Istituti di Ricovero e Cura a Carattere Scientifico

Associazione Nazionale Medici Cardiologi Ospedalieri

Ospedale Civile di Venezia

Ca' Foncello Hospital

Società Italiana di Cardiologia

University of Florence

Ospedale Santa Maria

Ospedale Santa Maria della Misericordia di Rovigo

Author Statistics

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Citation

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Research Field

May We Select Patients Responder to Pacing for Atrial Fibrillation Prevention? The results of the Randomized and Prospective Epass Pilot Study

EP Europace (2005)

Roberto Verlato Francesco Zanon Emanuele Bertaglia Pietro Turrini S. Baccillieri

EPASS Pilot study compared right atrial appendage (RAA) and Interatrial Septum (IAS) pacing in patients (Pts) with SSS and atrial fibrillation (AF), in relation with the electrophysiologic study (EP) and pacing mode. 42 Pts (72±7 years old, 15M, 27F) were submitted to EP before randomization of pacing site and algorithms. The difference between basal and incremental conduction times (CT) was measured between the RAA and the coronary sinus os (csos) (delta-ctos). Pts with A2>100ms, ERP/A2<2,2, P wave duration >110ms and delta-ctos>60ms were group A. The remaining pts were group B. The number of AF episodes lasting more than 7 minutes (AF-Ep) was collected at 2 follow-ups of 3 months each by the pacemaker Selection 9000 (Vitatron). Group A (IAS) showed a reduction of AF-Ep/day with algorithms (p = 0,049) as to standard DDD. Group A (RAA) showed an increase of AF-Ep/day (p = 0,046) when continuously paced. Group B did not show statistically significant differences between DDD and DDD + Algorithms. Pts with RA severe conduction delay may benefit of continuous pacing in the IAS, but not in the RAA.

SSS*

Interatrial septum

10.1016/j.eupc.2005.08.101

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Citations (0)

[The function of the sinus node in conduction disorders].

PubMed (1976)

L Artusi R. Cazzin A Raviele P Pascotto F Lucangeli

Sinus (botany)

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Effects of oral calcium-antagonists in spontaneous angina. Verapamil and nifedipine in a double-blind cross-over trial.

PubMed (1982)

E Piccolo R. Cazzin F Sartori L Artusi P Pascotto

Verapamil and nifedipine, two calcium-antagonist drugs, were evaluated in a double-blind cross-over trial. The study was performed in 15 patients admitted to our Coronary Care Unit for spontaneous angina. Before and after a 24 hours placebo period, oral verapamil 480 mg daily and oral nifedipine 60 mg daily were administered alternatively. Symptomatic as well as asymptomatic ischemic episodes with ST segment elevation or depression and ventricular and supraventricular ectopic beats were documented by continuous electrocardiographic Holter monitoring. The average number of attacks during the placebo periods was 243; the number of attacks decreased to 129 during verapamil treatment (P less than 0.05) and to 57 during nifedipine treatment (P less than 0.01). Ventricular ectopic beats decreased with both drugs while supraventricular ectopic beats decreased only during verapamil treatment. The difference was not statistically significant because of a small number of observations. In conclusion the two drugs appear to be effective in the management of patients with unstable angina at rest, especially in the variant form.

ST depression

ST elevation

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Citations (4)

[Calculation of sino-atrial conduction time with the modified Narula technic. Comparison with the Strauss technic].

PubMed (1978)

A Raviele D D’Este F Sartori F Dainese Pietro Delise

Source

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Citations (0)

[Rate responsive electrostimulation. Recent findings].

PubMed (1986)

R. Cazzin Di Pede F P Pascotto

Source

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Mid-diastolic intraventricular functional block. A new mechanism for intermittent intraventricular blocks?

PubMed (1984)

Pietro Delise Daniela D'Este Di Pede F Antonio Raviele Aldo Bonso

Experimental and clinical studies have demonstrated the existence of phase 3 and phase 4 functional blocks. In this report six cases are presented in which the electrophysiological study demonstrated the existence of a functional intraventricular block different from phase 3 and phase 4 blocks. In these cases the occurrence of the block was related to the presence in mid-diastole of a zone of block preceded and followed by intervals of unimpaired conduction. In two of 6 cases the functional block (infrahisian block) was not present in the basal tracing; it occurred during programmed atrial stimulation in a range of critical H1H2 coupling intervals delivered late in diastole, and did not appear after earlier stimuli. In the remaining four cases the conduction disturbance (2 RBBB, 2 infrahisian blocks) was present in the basal tracing, but disappeared both during early and late supraventricular extrastimuli, the first having short H1H2 intervals, the latter having H1H2 intervals longer than H1H1 basal cycle length. The width of the mid-diastolic zone of block varied from a few msec to hundreds of sec, and increased as heart rate increased. Two hypotheses are put forward in order to explain the electrophysiological mechanism responsible for the phenomenon: 1) a longitudinal dissociation in the conducting system, generating two different ways, one having a long refractory period, the other having a phase 4 spontaneous depolarization; they would be responsible of phase 3 and phase 4 blocks respectively. The early and late zones of conduction could be explained by an alternate conduction in one of the two ways, while the mid-diastolic zone of block could be due to a simultaneous block in both ways; 2) the existence of a diastolic oscillatory potential (late after-depolarization). In the latter case we can suppose that the mid-diastolic block was due to the stimulation of the cells of the conducting system before the restoration of the normal diastolic potential. Our electrophysiological data offer a new contribution to the understanding of intermittent intraventricular blocks. However further experimental and clinical studies are needed to confirm our electrophysiological hypotheses.

Diastolic depolarization

Intraventricular conduction

Basal (medicine)

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Citations (1)

Single-lead VDD-pacing system incorporating high impedance stimulation: a multicentre study

EP Europace (2002)

Bernd Nowak Carsten W. Israel D. Gascon MARIE KNOPS G. Campanale

The purpose of this study was to evaluate the performance of a new VDD pacing system incorporating a high impedance, single-pass VDD lead. The new lead is a bipolar, steroid-eluting, high impedance lead with a full-ring atrial dipole.The system was implanted in 46 patients with high degree atrioventricular (AV) block. Patients were followed at pre-discharge, 6 weeks, and 3 months. The mean measured P-wave amplitude was stable, with values between 1.18 and 1.43 mV. Atrial sensing was reliable during short-term evaluation at rest and in the sitting position, with AV-synchronous stimulation between 98.79 +/- 6.90% and 99.73 +/- 1.47%. Holter recordings after 6 weeks demonstrated AV-synchronous stimulation in 99.57 1.03% of all P-waves. Lead impedance was stable during follow-up, with mean values between 1000 and 1167 Q. Mean ventricular pacing thresholds (at 0.5 ms) were 0.47 V at implant, 0.49 V at pre-discharge, 0.74 V at 6 weeks, and 0.72 V at 3 months. R-wave amplitude remained stable between 14.9 and 16.7 mV during follow-up.This new single-pass VDD lead system provided reliable atrial sensing and stable high impedance stimulation during a 3-month follow-up period.

Lead (geology)

High impedance

Atrioventricular block

Sitting

10.1053/eupc.2002.0224

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Citations (2)

[Nifedipine and verapamil in unstable angina. Evaluation by the Holter method].

PubMed (1982)

E Piccolo R. Cazzin F Sartori L Artusi P Pascotto

Source

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Citations (0)

[Circumferential isolation of pulmonary veins with transcatheter radiofrequency ablation in the treatment of atrial fibrillation].

PubMed (2003)

Emanuele Bertaglia Scarabeo Franco Zoppo C Zerio Nicola Pellizzari

Circumferential anatomical isolation of the pulmonary veins by radiofrequency transcatheter ablation is a new technique for the treatment of atrial fibrillation (AF). The aim of our study was to evaluate the efficacy and the safety of circumferential radiofrequency ablation of the pulmonary veins and to analyze clinical, echocardiographic and procedural parameters as possible predictors of clinical success.We performed circumferential isolation of the pulmonary veins in 33 patients with paroxysmal (15 patients) or persistent AF (18 patients) refractory to at least two antiarrhythmic drugs. All patients continued antiarrhythmic therapy after the procedure for at least 12 months.At the end of the follow-up (mean 13.7 +/- 5.1 months) 70% of the patients resulted responders to the ablation, with no differences between patients with paroxysmal and persistent AF. Complications were observed in 3% of patients. Among clinical, echocardiographic and procedural parameters analyzed none turned out to be predictor of clinical success.Circumferential isolation of the pulmonary veins by radiofrequency transcatheter ablation associated with antiarrhythmic drugs was efficacious in 70% of patients with either paroxysmal or persistent AF. None of the analyzed variables predicted clinical success.

Refractory (planetary science)

Paroxysmal atrial fibrillation

Clinical efficacy

Isolation

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Citations (3)

[The effects of enalapril on basal arterial pressure at rest and during exercise and on cardiac performance in hypertensive athletes].

PubMed (1990)

D D’Este Franco Giada F Sartori Donatella Noventa S Cinquemani

A dose of 10 mg of enalapril was administered once a day to regularly trained hypertensive athletes (mean age 39 +/- 8.9 range 29-51) in order to evaluate the effect of the drug on ambulatory blood pressure and on blood pressure and physical performance during stress testing. STUDY DESIGN. This investigation was a randomized, double blind, cross-over versus placebo trial. At first, subjects whose blood pressure met the entry criteria (casual diastolic blood pressure greater than or equal to 95 mmHg), were subjected to 24-hour ambulatory blood pressure monitoring and maximal upright bicycle stress testing including measurement of O2 uptake. Then they were randomly assigned to treatment with placebo or enalapril. After one month they repeated stress testing and then they were crossed over. Stress testing was repeated in all subjects after two months. The 24-hour ambulatory blood pressure monitoring was repeated in all subjects during enalapril treatment only, by a non-blind investigator. RESULTS. Ambulatory blood pressure decreased significantly during enalapril and no changes in heart rate were observed during the monitoring. The results of bicycle stress testing, both in basal and during the placebo test were comparable as regards blood pressure response, maximal workload, effort duration, maximal heart rate and VO2 max. With enalapril systolic and diastolic blood pressure decreased significantly during stress testing both versus basal test and placebo test at each workload considered including maximal workload. No changes were observed during enalapril as regards maximal workload, effort duration, maximal heart rate and VO2 max. CONCLUSION. Our results suggest that enalapril could be effective in treating hypertensive athletes because it reduces blood pressure during physical effort without affecting physical performance. We conclude that enalapril could be considered a first-choice drug in hypertensive athletes doing aerobic sports.

Stress testing (software)

Basal (medicine)

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Citations (3)