A 47-year-old-woman was admitted to our hospital complaining of thirst and dry cough after catching cold. Sjögren's syndrome (SjS) and systemic lupus erythematosus (SLE) were diagnosed. Chest X-P and CT findings suggested strongly that she had interstitial pneumonia. Thoracoscopic lung biopsy was therefore performed, and the biopsy specimens showed marked infiltration of small lymphocytes and of plasma cells into the alveolar walls and interlobular septa. Since the infiltrating cells were not atypical and gene analysis did not show mono-clonality, we made a diagnosis of lymphocytic interstitial pneumonia (LIP). Because the patient's symptoms appeared only after she caught cold, we suspected that virus infections were somewhat involved in the etiology of these diseases. The level of human herpesvirus-6 (HHV-6) antibody was high, and furthermore, HHV-6 was detected using the polymerase chain reaction from lung biopsy specimens. We suspected in this case that LIP, SjS, and SLE had appeared concomitantly after an active HHV-6 infection.
Hydroxyapatite (HAP) is currently utilized as biomaterials for implantation or reconstruction of bone defect in dentistry. In order to obtain better physical properties and biocompatibility, we have developed cylindrical sintered porous HAP which has longitudinal internal tubules. We measured compressive strength and specific surface area of cylindrical HAP. In the results, compressive strength was more 300MPa on average and specific surface area was 1.7-2.4 folds as HAP ceramics commercially available. This result indicates new bone formation. Cylindrical HAP used was subsequently applied to lower premolars and molars of male beagle dogs (1.5 years). We have implanted cylindrical HAP to bone defect of postextraction of tooth followed to sacrifice six months after. Specimens of bone block were stained with Villanueva bone stain and observed with fluorescence microscope and scanning electron microscope. New tissue formation was observed invading into tubules of 27 microns diameter of cylindrical HAP particles. This new tissue was confirmed to be bone tissue because the proportion of Ca to P was 1.616 obtained by energy dispersive X-ray analyzer.
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Abstract Das N‐Acetoxy‐benzoxazinon (Ic) reagiert in unterschiedlicher Weise mit den Boa‐Aminosäureestern (II), (V) bzw. (VII) zu den Verbindungen (III) und (IV) bzw. (VI) bzw. (VIII).
Abstract The distribution of human herpesvirus 6 (HHV‐6) and varicella‐zoster virus (VZV) was examined in autopsy samples from a fatal case with both virus infections. A 9‐month‐old boy developed convulsive seizures followed by macular skin rashes, rapidly progressed to brain death, and died 15 days after the onset, when signs of varicella were noted. An isolation of HHV‐6 from blood and evaluation of antibody activities to various viral agents including HHV‐6 were performed before his death. Postmortem examinations included: (i) isolation of HHV‐6 and VZV from tissues or organs; (ii) detection of both virus antigens in tissues or organs by an indirect immunofluorescent assay using monoclonal antibodies to both viruses; (iii) amplification of both viruses and human herpesvirus 7 DNA sequences by a nested polymerase chain reaction assay; and (iv) endonuclease digestion of amplified products of HHV‐6 DNA for differentation of variants A and B. Human herpesvirus 6 DNA was detected in peripheral blood mononuclear cells (PBMC) and plasma obtained at the eruptive stage but present only in PBMC 15 days after, indicating the primary infection with HHV‐6, although the virus was not isolated from the same blood sample and a significant rise in the antibody titers to HHV‐6 was not observed. Both virus antigens and DNA were detected in various tissues or organs obtained at autopsy, but only VZV was isolated from these samples, suggesting disseminated infection with both viruses in an infant. All the amplified products of HHV‐6 DNA were variant B. Among the findings for the distribution of virus antigens, it was noteworthy that HHV‐6 antigen was demonstrated in the endothelial cells of small vessels in the frontal lobe of the brain. There was no evidence of HHV‐7 infection. These data indicate that the primary HHV‐6 infection closely followed by the primary VZV infection had the potential hazard of an unexpected and apparently life‐threatening event, in which disseminated infections with both viruses were noted in multiple tissues or organs including the brain.
Abstract The title compounds (IV) which constitute stable derivatives of the cyclopropylcyclohexadienone ring system of the CC‐1065 left‐hand subunit and the functional analogues of the antitumor‐antibiotic CC‐1065, viz.
Abstract The cytotoxic potency of the CBI‐based agents (VI), (IX), (X) (with a benzene ring anellated to the indole) is found to be equipotent with the potent CPI‐based agents (with a 3‐methylpyrrole ring anellated to the indole).
