Nooruddin Ahmad

Bangabandhu Sheikh Mujib Medical University

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Shahinul Alam

Bangabandhu Sheikh Mujib Medical University

Golam Mustafa

World University of Bangladesh

Mobin Khan

Armed Forces Institute of Pathology

Golam Azam

Liaquat University of Medical & Health Sciences

Mamun Al Mahtab

Bangabandhu Sheikh Mujib Medical University

Saiful Islam

Bangabandhu Sheikh Mujib Medical University

Mahabubul Alam

Bangabandhu Sheikh Mujib Medical University

Khorshed Alam

Independent University

Kamrul Anam

National Institute of Cardiovascular Diseases

Salimur Rahman

Georgetown University

Cooperative Institutions

Bangabandhu Sheikh Mujib Medical University

Dhaka Medical College and Hospital

Shaheed Suhrawardy Medical College

International Centre for Diarrhoeal Disease Research

Dinajpur Medical College

Rangpur Medical College

National Institute of Cardiovascular Diseases

Nagoya City University

Comilla Medical College

Toshiba General Hospital

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Association of single nucleotide polymorphism at PNPLA3 with fatty liver, steatohepatitis, and cirrhosis of liver

Indian Journal of Gastroenterology (2017)

Shahinul Alam Mohammad Shaiful Islam Saiful Islam Golam Mustafa Ahmed Abu Saleh

Steatohepatitis

Steatosis

10.1007/s12664-017-0784-y

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Citations (12)

Seroprevalence of Hepatitis C Virus Infection Among Health Care Workers

Journal of Bangladesh College of Physicians and Surgeons (1970)

Shahinul Alam Nooruddin Ahmad Mobin Khan Golam Mustafa

Background and aims: Parenteral route is the principal mode of transmission of Hepatitis C Virus (HCV). Health care workers are at risk of infection with HCV. Aim of study was to estimate seroprevalence of HCV amongst health care workers and identify possible risk factors of HCV infection. Materials and Methods: 355 health care workers were selected from July 2005 to June 2006 working in different departments of Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Among them 43.5% were doctors, 32.1% nurses, 11.8% ward boys, 5.9% operation theatre staffs (OT staffs), and 6.8% others. Sera were tested for HCV antibodies by ELISA. Data analyzed by SPSS 10.0 version. Results: Mean age was 31.56±7.4 years. Males were 51.4% and females 48.6%. Anti-HCV was positive in 5(1.4%) cases out of 355. Most prone to HCV infection were nurses (3) followed by doctor (2). No ward boy or OT staff was affected. Previous surgical (80%) and dental procedures (60%) were the main risk factors than recipients of blood transfusion (20%), intravenous drug users (20%), and multiple sexual exposures (20%). Conclusions: Nurses are more prone to HCV infection. Surgical procedures are the main risk factors for acquiring HCV infection. Proper sterilization of surgical instruments is recommended. (J Bangladesh Coll Phys Surg 2007; 25 : 126-129)

Seroprevalence

Universal precautions

Hepatitis C

10.3329/jbcps.v25i3.408

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Citations (9)

Effect of pentoxifylline on histological activity and fibrosis of nonalcoholic steatohepatitis patients: A one year randomized control trial

Journal of Translational Internal Medicine (2017)

Shahinul Alam SKM Nazmul Hasan Golam Mustafa Mahabubul Alam Mohammad Amjad Kamal

To observe the effect of Pentoxifylline for 1 year on hepatic histological activity and fibrosis of nonalcoholic steatohepatitis (NASH).

Pentoxifylline

Nonalcoholic steatohepatitis

Nephrology

Steatohepatitis

10.1515/jtim-2017-0021

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Citations (26)

Study On Ascitic Fluid Complement3 Level In Cirrhotic Patients With Spontaneous Bacterial Peritonitis And Without Spontaneous Bacterial Peritonitis

The Internet Journal of Gastroenterology (2006)

Golam Mustafa Shahinul Alam Mobin Khan Korshed Alam Salimur Rahman

Background: Ascitic fluid Complement 3 is important factor to offer local defence against infection of ascitic fluid. Hepatic synthesis of Complement3 and it's concentration in ascitic fluid is reduced in patients with advanced cirrhosis. The study aimed to assess Complement3 in ascitic fluid in patients with Spontaneous Bacterial Peritonitis and without Spontaneous Bacterial Peritonitis and identify cirrhotics at risk of developing Spontaneous Bacterial Peritonitis. Methods: A prospective case-control study done to compare the ascitic fluid Complement3 level in patients with Spontaneous Bacterial Peritonitis (case-group) and without Spontaneous Bacterial Peritonitis (control-group). Ascitic fluid Complement3 was estimated in 15 patients with Spontaneous Bacterial Peritonitis (case) and another 15 patients without Spontaneous Bacterial Peritonitis (control). Results: Ascitic fluid Complement3 level was 7.3± 4.3 mg/dl in patients with Spontaneous Bacterial Peritonitis and 16.4 ± 11.3 mg/dl in patients without developing Spontaneous Bacterial Peritonitis. Conclusion: Ascitic fluid Complement3 is significantly (P=0.009) reduced in cirrhotics who develop Spontaneous Bacterial Peritonitis.

Spontaneous bacterial peritonitis

Ascitic fluid

Microbiological culture

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Citations (3)

The Ascitic Fluid Fibronectin Level to Differentiate Malignant From Nonmalignant Ascites

Scholars Journal of Applied Medical Sciences (2020)

Mohammad Nurul Islam Khan Nooruddin Ahmad Dr. Md. Abdul Kader Zilani Priobrata Karmakar Sushanta Kumar Barman

Objective: In this study our main goal is to evaluate the ascitic fluid fibronectin level to differentiate malignant from nonmalignant ascites.Method: This observational, cross sectional type study conducted in Department of Hepatology, Bangabandhu Sheikh Mujib Medical University, Dhaka from September 2014 to February 2017.During the study period of total 60 patients (30 patients with malignant ascites and 30 patients with nonmalignant ascites) were enrolled for the study.Results: Mean ascetic fluid fibronectin was found 0.50±0.15µg/ml in malignant ascites group and 0.22±0.07µg/ml in nonmalignant ascites group.Mean ascitic fluid fibronectin was found 0.64±0.11µg/ml in positive for malignant cell group and 0.45±0.17µg/ml in negative for malignant cell group.The mean difference was not statistically significant (p>0.05) between two groups.Sensitivity of cut off value of ascitic fluid fibronectin ≥0.22 µg/ml was 82.86%, specificity 96.0%, accuracy 88.33%, positive and negative predictive values were 96.67% and 80.0% respectively.Conclusion: The present study revealed on the usefulness of fibronectin in the differential diagnosis of ascites and these data and findings suggest that fibronectin may have potential value to differentiate malignant from nonmalignant ascites.

Ascitic fluid

10.36347/sjams.2020.v08i07.003

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Presentation and endoscopic management of biliary ascariasis.

PubMed (2007)

Shahinul Alam Golam Mustafa Nooruddin Ahmad Mobin Khan

Ascaris lumbricoides is a common parasite and the most serious and dramatic presentation is hepatobiliary and pancreatic ascariasis (HPA). Therefore, this study was planned prospectively to elucidate the clinical presentation of HPA and evaluate the efficacy and safety of endoscopic intervention. In this study we documented 77 consecutive patients with HPA from January 2000 to November 2005. All the patients had endoscopically proven HPA. A total of 77 patients were included in the study. The age ranged from 6 to 80 years, with the third decade most commonly (28.6%) affected. Females were 6 times more likely to be affected than males. The commonest presentation was biliary colic (97.4%); other presentations were acute cholangitis (15.6%), obstructive jaundice (9.1%), acute pancreatitis (6.5%), choledocholithiasis (6.5%), acute cholecystitis (6.5%) and liver abscess (2.6%). In this report 51 (66.2%) had living, 10 (13%) had dead and 16 (20.8%) had both living and dead worms. Choledocholithiasis was associated only with dead worms. From one to 23 worms were found in the biliary tree. In 94.8% of cases we had to remove the worm by wide papillotomy followed by basket extraction. We did not experience any major complications during or following the procedures. Three patients had recurrent HPA during the course of follow-up (1 to 12 months). The majority of patients with HPA presented with biliary colic. This should be kept in mind in the management of an acute abdomen, especially in tropical countries. Endoscopic extraction is a safe and effective procedure for the treatment of HPA.

Biliary colic

Presentation (obstetrics)

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Citations (35)

Evaluation of normal or minimally elevated alanine transaminase, age and DNA level in predicting liver histological changes in chronic hepatitis B

Liver International (2011)

Shahinul Alam Nooruddin Ahmad Golam Mustafa Ananta Shrestha AKM Khorshed Alam

Serum alanine transaminase (ALT), hepatitis B virus (HBV) DNA level and age are used in the evaluation of chronic hepatitis B (CHB).We designed this study to evaluate liver histology with ALT and its relation with age and HBV DNA.During the period of October 2006 to July 2009, 499 CHB patients were included in this study with detectable HBV DNA at PCR. Of these, 181 had normal ALT, 200 had ALT [>(1 × ULN) < (2 ULN)] and 118 had ALT ≥ 2 ULN and were labelled as Group 1, 2 and 3 respectively.A strong positive correlation was found between ALT and histological activity index (HAI) and fibrosis. However, 29 (52.7%) and five (9.1%) in Group 1 with positive HBeAg status had HAI ≥4 and fibrosis ≥2 respectively. Among those with HBeAg-negative status, 66 (23.1%) had HAI >4 and 31 (10.8%) had fibrosis ≥2. In Group 2, 14 (15.7%) had moderate-to-severe HAI and 19 (21.2%) had fibrosis ≥2 when HBeAg was positive, in those with HBeAg negative 34 (30.6%) had moderate-to-severe HAI and 38 (34.2%) had fibrosis ≥2. An ALT value of ≥58.5 U/l had higher sensitivity than that of 80 U/l in predicting significant histological changes. Further, HAI and fibrosis were significantly greater in the age of >30 years.We recommend liver biopsy in HBeAg-negative CHB over 30 years of age regardless of ALT level and starting treatment at ALT 1.5 × ULN instead of 2 × ULN.

Alanine aminotransferase

Transaminase

Aspartate transaminase

Aspartate Aminotransferases

Alanine

10.1111/j.1478-3231.2011.02491.x

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Citations (44)

Frequent coinfection with hepatitis B virus strains of distinct genotypes detected by hybridization with type-specific probes immobilized on a solid-phase support

Journal of Virological Methods (2003)

Hideaki Kato Etsuro Orito Fuminaka Sugauchi Ryuzo Ueda Takuya Koshizaka

Orthohepadnavirus

10.1016/s0166-0934(03)00095-8

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Citations (47)

Correlation Between HBeAg Status, HBV DNA, ALT, AST, GGT and Liver Histological Activity in Patients With Chronic Hepatitis B Virus Infection

Journal of Clinical and Experimental Hepatology (2017)

Kazi Z. Hossain Nooruddin Ahmad Sheikh Mohammad Noor-E-Alam Md J. Sarker Foyez A. Khondoker

HBeAg

10.1016/j.jceh.2017.05.053

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Past, Present, and Future of Hepatitis B and Fatty Liver in Bangladesh

Shahinul Alam Golam Azam Golam Mustafa Mahabubul Alam Nooruddin Ahmad

Chronic hepatitis B (HBV) is one of the major diseases of mankind, estimated to cause about 686,000 deaths per year mostly from liver cancer and cirrhosis. And globally about 240 million people are chronically infected with hepatitis B. Nonalcoholic fatty liver disease (NAFLD) is an emerging commonest cause of chronic liver disease in the world. We have searched for CHB, NAFLD in PUBMED, Google scholar and hard copies of local journals and related available articles were included in this review. Along with 184 countries of the world Bangladesh adopted hepatitis B vaccine in his EPI (expanded program on immunization) schedule for its prevention. And now about 95% of children are under cover of Hep B vaccine. Along with globally inlast two decades’ seroprevalence of HBsAg reduced about four times in Bangladesh. The prevalence of recorded nonalcoholic fatty liver disease (NAFLD) varies considerably by ethnic group and Bangladeshi ethnicity is an independent risk factor for NAFLD. The prevalence of NAFLD in Bangladesh is vary from 4%-18.4% and it is increasing day by day. About 40% of them are nonalcoholic steatohepatitis (NASH). They are in danger of progression to cirrhosis and hepatocellular carcinoma (15-19%) in next 5 to 10 years. Now it’s becoming a silent killer for our nation. Gradual development of affluence, sedentary life style and increasing prevalence of diabetes contributed behind it. No effective treatment is available till now. Life style change by diet, exercise and weight reduction is the main stay of treatment. NAFLD involve multiple organs that leads to death due to cardiac, neurological and liver disease. Government and health department should take multidisciplinary action programs in awareness building and make a national guideline for fatty liver management.

Hepatitis B

10.15406/ghoa.2017.6.00197

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Citations (4)