The production of adenosine 3′,5'-monophosphate (cyclic AMP) in a membrane preparation from human liver homogenate has been studied. Cyclic AMP production was enhanced by glucagon, guanylyl 5'-imidodiphosphate (GMP-PNP), or fluoride, or combinations of these. Adenosine, adenosine monophosphate (AMP) and adenosine diphosphate (ADP) at a concentration of 10−3 mol/1 antagonized the effects of all stimulants. These data suggest that inhibitory effects are exercised at the catalytic moiety of the adenylate cyclase system, or at the transducer function between hormone receptor and catalytic unit. In contrast, adenosine at a concentration of 10−5 mol/1 antagonized glucagon- but not fluoride-stimulated adenylate cyclase activity.

Adenine nucleotide

Adenosine monophosphate

10.3109/00365517809108426

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Citations (5)

Plasma cyclic nucleotides and plasma catecholamines before and after prolonged treatment with clonidine in hypertensive patients

European Journal of Endocrinology (1981)

Per Manhem Lise G. Hedïng Jörgen Malmquist B. Hökfelt

The effect of standing and physical exercise and catecholamines and cyclic nucleotides in plasma was measured in 8 patients with essential hypertension under standardized conditions before and after prolonged treatment with clonidine. Before clonidine medication noradrenaline, adrenaline and cyclic AMP (cAMP) increased in response to standing and bicycling for 20 min. No significant correlation was found between their absolute levels nor was the increase in cAMP following exercise correlated to the increase in noradrenaline. Standing and physical exercise were without effect on cyclic GMP (cGMP). Clonidine reduced the plasma noradrenaline concentration in supine position and the noradrenaline and the adrenaline response to standing and exercise. Plasma cAMP was uneffected by clonidine under basal conditions but the response to exercise was slightly reduced initially. During clonidine there was a positive correlation between the plasma levels of cAMP and noradrenaline following work. Clonidine produced an increase in plasma cGMP in supine position, immediately prior to bicycling and after 5 min of exercise.

Supine position

Basal (medicine)

10.1530/acta.0.0970405

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Citations (3)

[Alternative medicine: scrutiny of the methods, not of the certification!].

PubMed (2003)

Jörgen Malmquist

Scrutiny

Source

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Citations (0)

PubMed (2017)

Jörgen Malmquist

Source

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Plasma insulin and C-peptide in relation to glucose intolerance in middle-aged men

European Journal of Endocrinology (1982)

Jörgen Malmquist Folke Lindgärde Karl‐Fredrik Eriksson Elisabet Johansson

Abstract. The relation between glucose homeostasis and insulin secretion (immunoreactive insulin and C-peptide) was studied in middle-aged males matched for age and body weight. Subjects with mild type II diabetes mellitus were compared to normals and to individuals with impaired glucose tolerance (IGT). In addition, the diabetics were subdivided according to duration, some of the subjects having recently deteriorated from IGT status. In the IGT individuals, there were no indications of a reduction in basal or glucose-induced insulin output. On the contrary, data indicate somewhat higher than normal secretion. Within the type II diabetics, those of short duration were largely similar to normals, whereas diabetes of longer duration was associated with some diminution in indices of B cell secretion. The data support the notion that a deficient insulin output is not a primary pathophysiological event in the development of type II diabetes.

Basal (medicine)

C-peptide

Homeostasis

Pathophysiology

10.1530/acta.0.1000262

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Citations (7)

Familial Protein Intolerance

New England Journal of Medicine (1971)

Jörgen Malmquist R Jagenburg Göran Lindstedt

Thirteen cases of "familial protein intolerance," a hereditary defect in ammonium ion metabolism, have occurred in Finland. The nature of the metabolic defect has remained obscure. In a patient displaying clinical and biochemical features of "familial protein intolerance," but without documented familial occurrence, the main clinical features were intellectual impairment, with x-ray evidence of brain atrophy, and marked skeletal fragility. Intolerance to protein-containing foods was moderate. The postprandial blood ammonia concentration was moderately elevated, whereas intravenous L-alanine administration caused marked ammonia elevation as well as marked hyperglycemia. Biochemical findings indicated a defect in the mechanisms transferring amino nitrogen to the urea-synthesizing system.

Hyperammonemia

10.1056/nejm197105062841802

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Citations (17)

Stimulation of collagen production in growth-arrested myocytes and fibroblasts in culture by growth factor(s) from platelets

Experimental Cell Research (1981)

Lars Stavenow Thomas Kjellström Jörgen Malmquist

Platelet-derived growth factor

Thymidine

10.1016/0014-4827(81)90010-0

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Citations (22)

Plasma Myeloperoxidase and Lactoferrin Measured by Radioimmunoassay: Relations to Neutrophil Kinetics

Acta Medica Scandinavica (1975)

Niels Ebbe Hansen Jörgen Malmquist Jan I. Thorell

Abstract. In 31 patients, covering a wide range of blood neutrophil counts and turnover rates, the plasma concentrations of myeloperoxidase and lactoferrin have been measured with radioimmunoassays and compared to neutrophil kinetic parameters, measured with DF 32 P‐labeled neutrophils. It was found that the plasma concentrations of both proteins correlated significantly with the total number of neutrophils in the blood (TBGP=total blood granulocyte pool) as well as with the neutrophil turnover rate (GTR=granulocyte turnover rate), which is evidence that neutrophilic granulocytes are the main suppliers of myeloperoxidase and lactoferrin to the plasma. In contrast to the previously demonstrated better relationship between the GTR and plasma lysozyme, a protein also originating in neutrophil granules, both myeloperoxidase and lactoferrin correlated better with the TBGP. These differences may reflect differences in the mode of release of intragranular proteins from neutrophils to the plasma. The correlation of the plasma lactoferrin concentration with the TBGP was so good as to suggest its use in the clinical assessment of the TBGP.

Lactoferrin

Blood plasma

10.1111/j.0954-6820.1975.tb19572.x

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Citations (113)