Masateru Maruyama

National Institute of Technology, Nagano College

Author Statistics

Papers

Citation

H-Index

i-10 index

Research Field

[Two cases of complete response of primary esophageal carcinoma treated with 5-FU/CDDP as neoadjuvant chemotherapy].

PubMed (2011)

Kentaro Takahashi Hitoshi Kawasaki Naoki Wajima Keiichi Miyamoto Masateru Maruyama

CASE 1: A 67-year-old man with lower thoracic esophageal carcinoma, T2N0M0, cStage II, underwent neoadjuvant chemotherapy (NAC) with 5-FU/CDDP. After 2 courses of NAC, radical resection of the esophageal carcinoma was performed. Primary tumor was not palpable, and lymph node swelling was not found in the resected specimens. Pathologic examination of the resected specimens revealed no malignant cells in the esophagus. Histologic effect of the NAC was grade 3. We obtained down-staging of carcinoma in T0N0M0, fStage 0. CASE 2: A 58-year-old man with thoracic esophageal cancer, T3N2M0, cStage III, underwent NAC with 5-FU/CDDP. After 2 courses of NAC, radical resection of the esophageal carcinoma was performed. Primary tumor was not found in the resected specimens. Pathologic examination of the resected specimens revealed only an irregular fibrosis of esophageal wall, and no malignant cells in the esophagus. Two lymph node metastasis and surrounding fibrosis was found. We obtained down-staging of carcinoma in T0N2M0, fStage II. We report two cases of complete response of primary esophageal carcinoma treated with 5-FU/CDDP as neoadjuvant chemotherapy.

Primary tumor

Esophageal disease

Esophagectomy

Neoadjuvant Therapy

Source

Cite

Citations (2)

314 Effect of Retained Austenite Characteristics on Burring in TRIP steels

The Proceedings of Conference of Hokuriku-Shinetsu Branch (2009)

Akihiko Nagasaka Osamu Hara Masateru Maruyama Koh‐ichi Sugimoto Ryo AMAKI

10.1299/jsmehs.2009.46.107

Cite

Citations (0)

[Acute symmetric ulceration of the antral portion of the stomach. A new concept of hemorrhagic erosion and acute ulceration caused by spasm].

PubMed (1969)

K. Takagi K Kumakura Masateru Maruyama Hajime Sugano Kenji Nakamura

Source

Cite

Citations (0)

[Endoscopic treatment of early cancer of the large bowel].

PubMed (1986)

Masateru Maruyama Tsuneo Sasaki H. Kubota

The indication for endoscopic polypectomy as treatment of early cancer of the large bowel was studied in 766 polypectomized specimens which had been obtained over a period of 11 years (1973 to 1983) at the Cancer Institute Hospital, Tokyo and the following results were obtained. There were 15 lesions with remaining cancer at the polypectomy site. Thirteen cases of them were invasive cancer with massive submucosal invasion which could not be removed completely by polypectomy. There were 3 recurrent cancers: one of them had remained in the mucosal membrane, but the other two had developed into advanced cancer. The polypectomized specimens of these advanced cancers were diagnosed as invasive cancer with marked mucus production. In both cases there was massive submucosal invasion. Strict follow-up with short intervals is required in order to detect local recurrent cancer if prompt operation cannot be done in those cases which show invasive cancer. Endoscopic polypectomy is not indicated for lesions measuring larger than 18 mm in the largest diameter because there often occurred deep ulcer (Ul-III and IV) which indicated that colonic wall was liable to perforation.

Polypectomy

Perforation

Bowel perforation

Source

Cite

Citations (2)

[A case of Zollinger-Ellison syndrome associated with multiple endocrine adenomatosis (Type I)--special reference to treatment of Zollinger-Ellison syndrome with cimetidine (author's transl)].

PubMed (1979)

Keiko Shiratori Shinya Watanabe Yoshihiro Ohta Masateru Maruyama Teruo Kozu

Zollinger-Ellison syndrome

Cimetidine

Source

Cite

Citations (0)

[A case of advanced esophageal cancer patient surviving more than 7 years treated with chemoradiotherapy].

PubMed (2011)

Norihito Kubo Hitoshi Kawasaki Kentaro Takahashi Masateru Maruyama Keiichi Miyamoto

We report here a long-term survival case of advanced esophageal cancer with distant lymph node metastases, treated with definitive chemoradiotherapy (CRT). A man in his 60s with disturbance of swallowing was diagnosed as middle esophageal cancer involving multiple metastases of distant lymph nodes. CRT (combination of 5-FU and nedaplatin every four weeks for four courses with 66 Gy of radiation) was administered. After a completion of CRT, CT scan revealed shrinking metastatic lymph nodes. No tumor but a scar at the site of cancer was observed by endoscopy, and histopathology of biopsy specimen detected no tumor cells. From these results, we diagnosed the curative effect of CRT as complete response. Five years after CRT, a swelling of left inguinal lymph node with uptake of fluorine-18-fluorodeoxyglucose appeared and was extirpated, and the swelling was diagnosed histopathologically as metastasis of esophageal cancer. The patient is surviving with no recurrence for 7 years and 8 months from the first diagnosis. In cases of highly advanced esophageal cancer, a long-term follow-up should be performed.

Chemoradiotherapy

Nedaplatin

Histopathology

Source

Cite

Citations (0)

Chemosensitivity of human pancreatic carcinoma cells is enhanced by IkBα super‐repressor

Cancer Science (2003)

Toshiyuki Sato Hiroki Odagiri Shojiro‐Kazunori Ikenaga Masateru Maruyama Mutsuo Sasaki

Pancreatic cancer has an unfavorable prognosis; surgery and chemotherapy at present have only limited value. To improve the prognosis of pancreatic cancer, effective non‐surgical therapy is necessary. NF‐ k B is reported to be related to resistance to apopto‐sis, but its role in Chemosensitivity remains controversial. We examined the effects on Chemosensitivity of inhibition by induction of the super‐repressor I k Bα in pancreatic cancer cell lines, BxPC‐3, Capan‐1 and Panc‐1. I k Bα protein was transduced by infection of adenovirus vector AxCAhlkBδN. Sensitivity to VP‐16 and doxorubicin was increased significantly by I k Bα induction in all three pancreatic cell lines. To investigate molecular events during I k Bα induction, we examined the changes in expression of drug‐resistance‐related genes by real‐time RT‐PCR and those in apoptosis‐related genes by cDNA microarray. There was no common change of gene expression before and after I k Bα induction among the three pancreatic cancer cell lines, except for mdm2. Further examination of other genes is necessary for a better understanding of the molecular mechanisms of enhancement of Chemosensitivity through I k Bα induction. However, we have confirmed that I k Bα induction leads to an increase of Chemosensitivity of pancreatic cancer. Many problems remain before clinical application of this adenoviral system will be feasible, but our results may ultimately lead to an improved therapy of pancreatic cancer. (Cancer Sci 2003; 94: 467–472)

10.1111/j.1349-7006.2003.tb01466.x

Cite

Citations (21)

[Urinary trypsin inhibitor in cancer patients].

PubMed (1985)

Koji Onitsuka Hajime Sumi Masateru Maruyama Hiroshi Mihara

Source

Cite

Citations (2)

Efficient Gene Transduction in HER2-Expressing Cells by Two Recombinant Adenovirus Vectors with HER2 Promotor and Cre/loxP System

弘前医学 (2010)

Tatsuya Nodagashira Hiroki Odagiri Shojirokazunori Ikenaga Masateru Maruyama Toshiyuki Sato

Transduction (biophysics)

Cre-Lox recombination

Source

Cite

Citations (0)

[A case of complete remission(CR)persisting from UFT-E in an old patient with liver metastasis of gastric cancer].

Shojiro Kazunori Ikenaga Kimiaki Hirama Rikuro Matsumoto Masateru Maruyama Kazunori Aoki

A 82-year-old woman with gastric cancer underwent distal gastrectomy with level 2 lymph node dissection(M, Less, 2.2 x 2.0 cm, type 1, fH0, fP0, fM0, fT2, fN2(+), por 1, med, INF beta, ly2, v2, fPM(-), fDM(-), fStage IIIa). At first, adjuvant chemotherapy was not given because of her advanced age, but CEA increased to 43.2 ng/mL and a CT scan showed multiple liver metastasis. After we began oral chemotherapy with UFT-E 300 mg/day, the CEA level normalized and a CT scan revealed the liver metastasis had disappeared within about 9 months. There were no side effects for a course, and she has been free from any sign of recurrence. This was a very rare case in which single administration of UFT-E caused complete remission. Even an old patient should be treated aggressively because this treatment is relatively safe.

Adjuvant Chemotherapy

Source

Cite

Citations (0)