I Kam

University of Colorado Denver

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Michael Wachs

University of Colorado Denver

T Trouillot

University of Colorado Health

Tracy Steinberg

Medizinische Hochschule Hannover

S Mandell

University of Colorado Denver

B Bilir

Sağlık Bilimleri Üniversitesi

Mark D. Stegall

Mayo Clinic in Arizona

Gregory T. Everson

University of Colorado Anschutz Medical Campus

J Katz

Tel Aviv University

F Karrer

University of Colorado Denver

Conall T. Morgan

Hospital for Sick Children

Cooperative Institutions

University of Colorado Denver

University of Colorado Health

All India Institute of Medical Sciences

University of Colorado Anschutz Medical Campus

Technion – Israel Institute of Technology

University of Colorado Boulder

Cancer Institute (WIA)

Rambam Health Care Campus

Children's Hospital Colorado

All India Institute of Medical Sciences Bhopal

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Accuracy of Patient Setup in Breast Cancer Radiation Therapy Using Cone Beam Computed Tomography and Surface-Guided Radiotherapy - A Comparative Analysis

International Journal of Radiation Oncology*Biology*Physics (2024)

Abiramasundari Vivekanandan Sunil Chaudhary A. Aashita Adhar Amritt Arunima Ghosh

Image-guided radiation therapy

10.1016/j.ijrobp.2024.07.438

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Citations (0)

Are pediatric donors well utilized?

PubMed (1990)

Everett K. Spees J. P. Orlowski I Kam F. William Karrer Steven M. Dunn

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Citations (4)

A Safe Surgical Technique for the Infradiaphragmatic Removal of Cavai Tumor Thrombus Complicating Renal Cell Carcinoma

European Urology (1989)

Boaz Moskovitz I Kam Moshe Bolkier Dana Levin

Vena cava

10.1159/000471533

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COSTS OF CYCLOSPORINE (NEORAL®) AND TACROLIMUS (PROGRAF®) IN THE FIRST YEAR AFTER LIVER TRANSPLANTATION (OLT).

Transplantation (1998)

Gregory T. Everson Roshan Shrestha T Trouillot B Bilir A Amponsah

195 Background: Few controlled trials have compared costs incurred by immunosuppression with Neoral® (NEO) versus Prograf® (PRO) under otherwise identical conditions within a single center. We recently conducted a study with 1:1 randomization to NEO:PRO, fixed dosing with mycophenolate mofetil, and rapid prednisone withdrawal. Our aims were to define: 1) steadystate pharmacokinetics, 2) doses, and 3) costs for NEO and PRO.Methods: 45 men and 41 women underwent OLT and were randomized to NEO or PRO. All withdrawn from prednisone (14 days) and received mycophenolate mofetil for 6 months (2g/d for 3 months, then 1g/d for 3 months). NEO and PRO levels were measured by Abbott TDX® and IMX® flourescent polarization methods. Doses of NEO and PRO were based on target blood levels (NEO 300±50 and PRO 10-15 ng/ml) from days 0 to 14 but after 6 months doses were adjusted to suppress rejection. Cost was based upon $0.037/mg for NEO and$1.59/mg for PRO. Results:TableCost of NEO was slightly greater than PRO in the first 6 months ($2,851 vs$2,746), but less in the next 6 months ($2,030 vs $2,534). Based upon doses at 1 year post-transplant we estimate that maintenance with NEO may cost 22% less than PRO. Conclusions: Bioavailability of PRO is similar carly (1.69 ng/ml/mg PRO) and late post-transplant (1.62 ng/ml/mg PRO) but bioavailability of NEO (0.52 ng/ml/mg NEO; 0.96 ng/ml/mg NEO) doubles. Changes in bioavailability are the reason why NEO is more costly carly and less costly later post-transplant. Cholestasis likely accounts for poor bioavailability of NEO early post-OLT.

Immunosuppression

Mycophenolate

10.1097/00007890-199805131-00195

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Citations (3)

Beating the Clock: An Audit of Time Taken to Deliver Swallowing Sparing IMRT for Head and Neck Carcinoma

International Journal of Radiation Oncology*Biology*Physics (2024)

I Kam Tenzin Choden A. Aashita Arunima Ghosh A. Dagar

10.1016/j.ijrobp.2024.07.1204

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Involved Quadrant Irradiation (IQI) Post Breast Conservation Surgery: Preliminary Results of Ongoing Phase 3 Randomized Controlled Trial

International Journal of Radiation Oncology*Biology*Physics (2024)

Dheeraj Sharma Shivani Saini Avinash Iyer Menaka Jha I Kam

Quadrant (abdomen)

10.1016/j.ijrobp.2024.07.734

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Primary repair of colon injuries.

PubMed (1983)

M Hashmonai Shlomo Torem I Kam J Farbstein A Schramek

Colonic injuries are usually treated by exteriorization, resection and colostomy, or primary repair with proximal colostomy. However, many cases of successful treatment of colonic wounds by primary suture without colostomy have been reported. Yet, these repairs are usually restricted to civilian injuries, stab wounds, perforations of the right colon, cases with few or no other organ injuries, a short time interval between injury and operation, absence of shock, and minimal fecal soiling. We considered lack of fecal spillage to be the only important factor for 12 consecutive patients, the majority war casualties, and performed primary colon repairs on them. All the other commonly accepted limiting factors were disregarded. There were no complications related to the bowel repair. Using these more liberal guidelines, the number of primary repairs of colonic injuries may be increased, thus reducing hospitalization time and cost, and more important, reducing morbidity and mortality associated with the creation and subsequent closure of colostomies.

Limiting

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Citations (24)

Biological Implications of Extracellular Adenosine in Hepatic Ischemia and Reperfusion Injury

American Journal of Transplantation (2013)

M.A. Zimmerman I Kam Holger K. Eltzschig Almut Grenz

Adenosine A3 receptor

Purinergic Signalling

Hypoxia

Adenosine kinase

10.1111/ajt.12398

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Citations (22)

Prednisone withdrawal late after adult liver transplantation reduces diabetes, hypertension, and hypercholesterolemia without causing graft loss

Hepatology (1997)

Mark D. Stegall G. Everson G Schröter F Karrer BM Bilir

We prospectively withdrew prednisone in 28 adult patients who had stable graft function more than 2 years after orthotopic liver transplantation (OLTx) and had been on 5 mg/d prednisone for at least 6 months. Prednisone was decreased from 5 mg/d to 2.5 mg/d for 1 month then stopped completely. Cyclosporine monotherapy was maintained at a level of approximately 200 ng/mL (TDX). Nineteen patients had prednisone withdrawn without complications. Four (14.2%) had modest elevations in liver function tests (two biopsy proven mild rejections and two were not biopsied). These four were treated with methylprednisolone boluses and then withdrawal of steroids again. Prednisone was restarted in five patients because of generalized fatigue and body aches (n = 4) and colitis (n = 1). Steroids later were successfully withdrawn in two of these patients. After prednisone withdrawal, three of five insulin-dependent diabetic patients were able to discontinue insulin therapy and their glycosylated hemoglobin levels improved. Four of fourteen hypertensive patients were able to discontinue antihypertensive medicines. Mean serum cholesterol decreased from 222.6 +/- 43.3 to 188.3 +/- 33.3 mg/dL (P < .001). The number of patients with serum cholesterol levels > 220 mg/dL decreased from 13 to 4. A control group of 24 patients maintained on 5 mg/d prednisone at least 2 years after liver transplantation also was studied. In this group during the study period, no diabetic became normoglycemic, no patient decreased their antihypertensive medicine, and the mean serum cholesterol levels did not change significantly. We conclude that prednisone withdrawal using cyclosporine monotherapy late after liver transplantation does not lead to graft loss and decreases the prevalence of diabetes, hypertension, and hypercholesterolemia. Symptoms occurring during withdrawal may be minimized by earlier or slower tapering.

10.1002/hep.510250132

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Citations (139)

Early steroid withdrawal in liver transplantation is safe and beneficial.

PubMed (1999)

Everson Gt T Trouillot Michael Wachs T BAK Tracy Steinberg

This report reviews the literature and discusses steroid withdrawal after hepatic transplantation. Our experience with steroid withdrawal is highlighted. The hypothesis is that steroid withdrawal from liver transplant recipients is safe and beneficial. A review of the English literature yielded 16 reports with a total of 901 patients (749 adults and 152 children). Most reports were nonrandomized and uncontrolled. Only two reports were randomized, controlled trials; three reports featured early steroid withdrawal (

Drug withdrawal

Steroid use

10.1053/jtls005s00048

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Citations (56)