Cecilia Martín

Hospital de Sant Pau

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S. Gómez

Centro Regional de Derechos Humanos y Justicia de Género, Corporación Humanas

Joaquim Marcoval

Universitat de Barcelona

Anthony Lucci

The University of Texas MD Anderson Cancer Center

Kendra R. Cook

The University of Texas MD Anderson Cancer Center

Balraj Singh

The University of Texas MD Anderson Cancer Center

María Ochoa de Olza

Ludwig Cancer Research

ÀF

Àngels Fabra

Bellvitge University Hospital

J.R. Ferreres

Institut d'Investigació Biomédica de Bellvitge

R.M. Penín

Bellvitge University Hospital

J. Notario

Bellvitge University Hospital

Cooperative Institutions

Universitat Autònoma de Barcelona

Universidad Nacional Autónoma de México

Bellvitge University Hospital

Institut d'Investigació Biomédica de Bellvitge

Universitat de Barcelona

The University of Texas MD Anderson Cancer Center

Vall d'Hebron Hospital Universitari

Hospital de Sant Pau

Autonomous University of Queretaro

Inserm

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CD4+CD45RO+CD25-/lowCD127+

Transplantation (2015)

Cristina Roldán Sònia Mirabet Cristina Cecilia Vicens Brossa Eulàlia Roig

Cardiac allograft vasculopathy (CAV) is a major limitation in long-term graft survival after heart transplantation (HTx). Its prediction and detection at an early stage is a challenge because an accurate, minimally invasive blood test is lacking. The aim of this study was to analyze the relationship of Tact (CD4CD45ROCD25-CD127) cells, Th1 cells, and thymus-derived regulatory (Treg) (CD4CD45ROCD25CD127) cells in peripheral blood with the development of CAV in HTx patients.First, we performed a cross-sectional study in 29 patients at least 2 years after HTx, 17 with CAV and 12 without CAV. We then prospectively followed a group of 38 patients for 2 years immediately after HTx surgery. In both groups, we analyzed the relationship between CAV and the effector-to-regulatory T cell ratio.In the cross-sectional study, patients with CAV showed statistically significant higher values of Th1-to-FoxP3Treg and Tact-to-CD127Treg ratios than non-CAV patients, with P less than 0.01 and P less than 0.001, respectively. Receiver operating characteristic curve analysis showed that the Tact:CD127Treg ratio was a potential biomarker of CAV, clearly discriminating CAV and non-CAV patients (area under curve [AUC] = 0.955; P = 0.001). In the prospective part of the study, we monitored the Th1:FoxP3Treg and Tact:CD127Treg ratios using the best tradeoff between anterior receiver operating characteristic sensitivity and specificity as a cutoff. Changes in the Tact:CD127Treg ratio were detected earlier than changes in the Th1:FoxP3Treg ratio. Both ratios were higher in HTx patients with CAV.The Tact-to-Treg ratio is a valuable follow-up marker to detect HTx patients at risk of developing CAV.

Tact

Interleukin-7 receptor

10.1097/tp.0000000000000493

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Citations (10)

10 CFTR p.Leu206Trp mutation: genotype-phenotype correlation in 12 Spanish cystic fibrosis (CF) patients

Journal of Cystic Fibrosis (2012)

Silvia Gärtner Teresa Casals Cecilia Martín Oscar Manuel Rodríguez Asencio A.L. Qasem Moreno

Genotype-phenotype distinction

10.1016/s1569-1993(12)60179-9

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Development of a purification procedure for native hepatitis C virus from human liver

SU Nielsen M.F. Bassendine Cecilia Martín S Ibrahim GL Toms

Source

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Pigmentación oral asociada al tratamiento con alfa-interferón y ribavirina para la hepatitis C

Actas Dermo-Sifiliográficas (2013)

Joaquim Marcoval J. Notario Cecilia Martín S. Gómez

10.1016/j.ad.2013.01.008

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Citations (4)

Patterns of Visceral Metastasis in Cutaneous Melanoma: A Descriptive Study

Actas Dermo-Sifiliográficas (2013)

Joaquim Marcoval J.R. Ferreres Cecilia Martín S. Gómez R.M. Penín

Some types of cancer tend to spread to certain organs. In the case of melanoma, uveal melanoma spreads almost exclusively to the liver, while cutaneous melanoma spreads to the liver and other organs. Although important advances have been made in our understanding of the molecular mechanisms underlying melanoma, few recent studies have focused on the patterns of visceral metastasis in cutaneous melanoma. The aim of this study was to retrospectively investigate whether clinicopathologic variants of cutaneous melanoma and primary tumor site might be associated with pattern and time of onset of metastasis to visceral sites, including the central nervous system (CNS).We included patients diagnosed with cutaneous melanoma between 1988 and 2009 with at least 2 years' follow-up.Of the 1083 patients studied, 92 developed visceral metastasis. The CNS was affected in 21 cases, the lungs in 24, the liver in 17, the digestive tract in 7, and multiple organs simultaneously in 23. Metastasis to the lungs, the liver, and the digestive tract occurred within 5 years in most cases, while metastasis to the CNS and multiple organs occurred later (>5 years in 38% and 43% of cases, respectively).Unlike uveal melanoma, cutaneous melanoma spreads to different organs without any particular predilection. We observed no significant associations between the site of visceral metastasis and either clinicopathologic variant or location of the primary tumor. Metastasis occurred within 5 years of diagnosis in most cases, but it can occur after 10 years.

10.1016/j.adengl.2012.12.006

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Citations (13)

Estudio descriptivo del patrón de diseminación visceral del melanoma cutáneo

Actas Dermo-Sifiliográficas (2013)

Joaquim Marcoval J.R. Ferreres Cecilia Martín S. Gómez R.M. Penín

10.1016/j.ad.2012.12.012

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Citations (14)

QS118. Evaluation of Androgen Receptor as a Therapeutic Target in Breast Cancer

Journal of Surgical Research (2009)

Cecilia Martín Balraj Singh Kendra R. Cook Anthony Lucci