Daofu Zeng

Shenzhen Institutes of Advanced Technology

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Liping Tong

Air Force Medical University

Di Chen

Shenzhen Institutes of Advanced Technology

Guozhi Xiao

Southern University of Science and Technology

Rong Xie

Fujian Medical University

Yuhui Li

Peking University

Zhenlin Zhang

Shanghai Sixth People's Hospital

Guoqing Li

Jiangsu University

Zeng Zhang

Shanghai Jiao Tong University

Qinglin Kang

Shanghai Sixth People's Hospital

Yanyan Zhu

Shanghai University of Electric Power

Cooperative Institutions

Chinese Academy of Sciences

Shenzhen Institutes of Advanced Technology

Southwest University

Shanghai Jiao Tong University

Shenzhen Technology University

Shenzhen University

University of Chinese Academy of Sciences

Shanghai Sixth People's Hospital

Huazhong University of Science and Technology

Rush University Medical Center

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Development of novel osteoarthritis therapy by targeting AMPK-β-catenin-Runx2 signaling

Genes & Diseases (2024)

Daofu Zeng Muhammad Ihtisham Umar Zhenglin Zhu Haobo Pan William W. Lu

Osteoarthritis (OA) is a debilitating chronic joint disease affecting large populations of patients, especially the elderly. The pathological mechanisms of OA are currently unknown. Multiple risk factors are involved in OA development. Among these risk factors, alterations of mechanical loading in the joint leading to changes in biological signaling pathways have been known as a key event in OA development. The importance of AMPK-β-catenin-Runx2 signaling in the initiation and progression of OA has been recognized in recent years. In this review, we discuss the recent progress in understanding the role of this signaling pathway and the underlying interaction mechanisms during OA development. We also discuss the drug development aiming to target this signaling pathway for OA treatment.

RUNX2

10.1016/j.gendis.2024.101247

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Assessment of Renal Parenchymal Fat Deposition and Hemodynamics in Type 2 Diabetes Mellitus using Functional MRI

Journal of medical imaging and radiation sciences (2024)

J. Liu Daofu Zeng

Parenchyma

Deposition

10.1016/j.jmir.2024.101579

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Author response: Specific deletion of Axin1 leads to activation of β-catenin/BMP signaling resulting in fibular hemimelia phenotype in mice

Rong Xie Yi Dan Daofu Zeng Qiang Jie Qinglin Kang

10.7554/elife.80013.sa2

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Runx2 controls the osteogenic fate of growth plate chondrocytes

Genes & Diseases (2024)

Daofu Zeng Jiamin Yu Ke Lu Dan Yi Zhidao Xia

RUNX2

10.1016/j.gendis.2024.101453

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Structures and magnetic properties of FePt/FeRh bilayer films

Chinese Science Bulletin (Chinese Version) (2015)

WenLi PEI Gentai EGAWA Guoqing Li Yuhui Li Fu Zheng

10.1360/n972014-01131

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Usefulness of mean platelet volume as a marker for clinical outcomes after out‐of‐hospital cardiac arrest: comment

Journal of Thrombosis and Haemostasis (2016)

Daofu Zeng

Mean platelet volume

10.1111/jth.13534

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Loss of Axin1 in limb mesenchymal cells leads to multiple synostoses syndrome-like phenotype in mice

The Innovation Medicine (2024)

Dan Yi Rong Xie Daofu Zeng Jun Xiao Guozhi Xiao

Multiple synostoses syndrome (SYNS) is a disease characterized by the fusion of multiple joints. Unfortunately, the underlying and critical signaling pathways of this disorder remain poorly understood. Given the pivotal role of Wnt/β-catenin signaling in skeletal development and the key regulatory effect of Axin1 and Axin2 in the β-catenin pathway, limb mesenchymal stem cell (MSC) specific Axin1 conditional KO (cKO) mice and Axin1/Axin2 double KO (dKO) mice were generated to explore their involvement in joint formation. Abnormalities, such as developmental defects in joints and fusions in multiple joint tissues were observed in both Axin1 cKO and Axin1/Axin2 dKO mice, which resemble to the characteristics of human SYNS disease including synostoses of carpal and tarsal bones, as well as ankylosis of elbow joint and knee joint. Administration of β-catenin or BMP inhibitor significantly reversed the joint fusion phenotype in Axin1 cKO mice. Our findings suggest that Axin1 plays a key role in joint formation by inhibiting β-catenin-BMP signaling and could potentially serve as a therapeutic target for SYNS.

10.59717/j.xinn-med.2024.100053

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Specific deletion of Axin1 leads to activation of β-catenin/BMP signaling resulting in fibular hemimelia phenotype in mice

eLife (2022)

Rong Xie Dan Yi Daofu Zeng Qiang Jie Qinglin Kang

Axin1 is a key regulator of canonical Wnt signaling pathway. Roles of Axin1 in skeletal development and in disease occurrence have not been fully defined. Here, we report that Axin1 is essential for lower limb development. Specific deletion of Axin1 in limb mesenchymal cells leads to fibular hemimelia (FH)-like phenotype, associated with tarsal coalition. Further studies demonstrate that FH disease is associated with additional defects in Axin1 knockout (KO) mice, including decreased osteoclast formation and defects in angiogenesis. We then provide in vivo evidence showing that Axin1 controls limb development through both canonical β-catenin and BMP signaling pathways. We demonstrate that inhibition of β-catenin or BMP signaling could significantly reverse the FH phenotype in mice. Together, our findings reveal that integration of β-catenin and BMP signaling by Axin1 is required for lower limb development. Defect in Axin1 signaling could lead to the development of FH disease.

Limb development

10.7554/elife.80013

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Citations (6)

Exchange spring in A1/L1 FePt composite and its application in magnetic force microscope

Applied Physics Letters (2015)

Guoqing Li Yanyan Zhu Yong Zhang Hujun Zhao Daofu Zeng

This paper reported fabrication of FexPt100-x films with (001) epitaxy on MgO(100) substrates. The atomic percentage of Fe was changed within the range of x = 10–85 in order to search the optimal atomic ratio for achieving both high and isotropic-like coercivity. It was found that the Fe60Pt40 film exhibited large coercivities exceeding 5 kOe along both in-plane and out-of-plane directions due to the formation of A1/L10 FePt composite. A penta-domain model for hard/soft/hard exchange spring system was proposed to interpret the anomalous magnetization behaviors observed in Fe60Pt40 sample. By using Fe60Pt40 as the magnetic coating layer on a probe of magnetic force microscope, the flux changes at a linear density of 1000 kfci could be readily observed at a resolution of ∼13 nm.

Domain wall (magnetism)

Hysteresis

10.1063/1.4913599

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Magnetic properties of <italic>L</italic>10-FePt(001)/<italic>A</italic>1-FePt bilayer exchange springs

Chinese Science Bulletin (Chinese Version) (2016)

Juan Wei Bin Du JiaQin LI YaQin YAO Yang Chen

资助摘要在加热到400℃的MgO(001)单晶基片上, 用磁控溅射法沉积30 nm厚A1相FePt软磁薄膜, 在T a =[400℃, 700℃]温度范围进行6 h热处理, 使其发生不同程度的A1→L1 0 转变.以此作为硬磁层, 在100℃继续生长不同厚度的A1相FePt, 得到具有(001)织构的L1 0 /A1-FePt双层磁性交换弹簧.T a ≤600℃, 硬磁层的覆盖率保持100%, 但晶粒尺寸有差别.T a =500℃和600℃, 硬磁层的有序度分别为0

Ampere

10.1360/n972016-00592

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Citations (1)