The slices of testicular tumors isolated from patients with high serum alpha-fetoprotein (AFP) levels were cultivated in vitro, and the synthesis of some serum proteins, including AFP, was demonstrated. The tumors were produced from yolk sac in rats by fetectomy. The tumors consisted of the various histological structures, such as of teratoma, yolk sac tumor, and very immature tumor. The tumors with yolk sac histology were able to produce AFP. The tumors induced in rats were transplantable, but the well-differentiated histology disappeared after transplantation. The capacity of AFP synthesis in transplanted tumors seemed to be maintained for generations in female rats but not in male rats.

Histology

Alpha-fetoprotein

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Citations (26)

AN AUTOPSY CASE OF PRIMARY OSTEOGENIC SARCOMA OF THE URINARY BLADDER

Acta Pathologica Japonica (1965)

Kokichi Kikuchi Kyoji Nakamura Fumio Nakajima Hiroshi Ohmuro

Summary A case of primary osteogenic sarcoma of the urinary bladder is reporte, and 20 comparable cases in the past literatures are reviewed. A careful study must be done before classifying a tumor as an osteogenic sarcoma, because there are many variants of bladder carcinomas. The possible histogenesis of osteogenic sarcoma of the bladder is discussed.

Primary (astronomy)

10.1111/j.1440-1827.1965.tb02893.x

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Citations (16)

A case of epithelioid leiomyosarcoma of the ileum with appearance of tumor cells in the ascites.

The Journal of the Japanese Society of Clinical Cytology (1997)

Mitsugu Ishizawa Kunio Mizuguchi Masataka Tanno Akihiko Yamamura Hanako Matsushima

腹水中に悪性細胞を認めた回腸類上皮平滑筋肉腫の1例を報告する. 症例は63歳の女性. 腹水細胞像は炎症性背景に, 類円形の大型細胞が散在性あるいは結合の弱い小集塊を形成し出現.核は類円形で偏在し, 核小体は大きく, 核縁不整もみられた. 細胞質は厚くライトグリーンに好染し, 空胞様に淡染する部分もみられた.肉眼的に腫瘍は18×8×7cm大で回腸の筋層から発生し潰瘍を伴い, 腸間膜, 大網, 膀胱に浸潤をみた.割面は白色調充実性で壊死を伴う.組織学的には円形や紡錘形の細胞が充実性に増殖し, 一見上皮様の構築を示した. 好銀線維は個々の腫瘍細胞を取り囲んでいた. 免疫染色では, EMA, サイトケラチン, ビメンチン, 平滑筋アクチンに陽性を示し, デスミン, ミオグロビンには陰性だった.電顕像では, 細胞質にミオフィラメントを認めた. 以上の所見から回腸の類上皮平滑筋肉腫と診断した. 本症例の腹水細胞像から平滑筋肉腫の推定診断はきわめて困難であったが, 本腫瘍の存在を念頭に鑑別診断の一つに入れる必要があると思われた.

10.5795/jjscc.36.190

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An Aged Male Patient with Autoimmune Hepatitis Complicated by Hepatocellular Carcinoma.

Internal Medicine (1999)

Kaoru Yamazaki T Kamiyama Sukenobu Shiba Akira Ebata Katsuaki Sugiura

An 82-year-old male patient was admitted for liver dysfunction. Laboratory test showed the following data; aspartate aminotransferase (AST) 79 IU/l, alanine aminotransferase (ALT) 28 IU/l, total bilirubin (T. Bil) 0.9 U, zinc sulfate turbidity test (ZTT) 48.9 U, gamma-globulin 4.9 g/dl, immunoglobulin G (IgG) 5,046 mg/dl, anti-nuclear antibodies x 320, anti-mitochondrial antibodies (-), hepatitis B virus surface antigen (HBsAg) (-), HBcAb (-), anti-hepatitis C virus (anti-HCV) (-), hepatitis C virus (HCV-RNA) (-), anti-hepatitis G virus (anti-HGV) (-), alpha-fetoprotein 306.8 ng/ml, carcinoembryonic antigen (CEA) 2.3 ng/ml, carbohydrate antigen (CA) 19-9 77.2 U/ml. Abdominal ultrasonography and computed tomography showed a large mass occupying most of the right lobe and portal thrombosis in the liver. Liver biopsy revealed cirrhosis with inactive hepatitis in the nontumorous lesion and well-differentiated hepatocellular carcinoma in the tumorous lesion. We report a rare case of an aged male patient with autoimmune hepatitis complicated by hepatocellular carcinoma.

Autoimmune Hepatitis

10.2169/internalmedicine.38.422

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Citations (13)

A case of prolonged operation of the activated sludge process of dipping former membrane separation by gravity filtration method.

Journal of Environmental Conservation Engineering (1999)

Takuji NAKANO Kyoji Nakamura Kiyoshi Izumi

Filtration (mathematics)

Gravity separation

Separation (statistics)

Separation process

10.5956/jriet.28.837

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CEREBRO‐HEPATO‐RENAL SYNDROME OF ZELLWEGER

Pathology International (1986)

Kyoji Nakamura Toshinao Takenouchi Miki Aizawa Shinichiro Arashima Masao Kawaguchi

An autopsy case of cerebro‐hepato‐renal syndrome of Zellweger, which occurred in a 14‐year‐old Japanese girl, is reported. The autopsy revealed widely distributed cystic changes in addition to renal blastema of both kidneys, and the liver was cirrhotic. The case was complicated by anomalies such as high forehead, strabismus, and partial defect of chorioidea. So far there have been only 10 reported cases of cerebro‐hepato‐renal syndrome of Zellweger in Japan.

Zellweger syndrome

Blastema

10.1111/j.1440-1827.1986.tb02236.x

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Citations (3)