Harald Olsen

Oslo University Hospital

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Jørg Mørland

Norwegian Institute of Public Health

Anders Andersen

Oslo University Hospital

Terje Simonsen

University Hospital of North Norway

Egil Bodd

University of Oslo

Magne Arve Flaten

Norwegian University of Science and Technology

Håkon Aune

Norwegian Cancer Society

Knut Waterloo

UiT The Arctic University of Norway

Steinar Aamdal

University of Oslo

Harald Arnesen

University of Oslo

Ulf E. Kongsgaard

Oslo University Hospital

Cooperative Institutions

University of Oslo

Oslo University Hospital

Norwegian Cancer Society

UiT The Arctic University of Norway

University Hospital of North Norway

University of Bergen

National Institute of Occupational Health

Haukeland University Hospital

Karolinska Institutet

Karolinska University Hospital

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In Vitro Effect of 4‐Methylpyrazole and Pyruvate on Ethanol Interaction with Propoxyphene Metabolism in Suspensions of Isolated Rat Hepatocytes

Acta Pharmacologica et Toxicologica (1985)

Egil Bodd Harald Olsen Jeran Jensen G. Hoist Wethe J Mørland

Forensic Toxicology

10.1111/bcpt.1985.57.3.219

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Citations (2)

DIETHYL ETHER INFLUENCE ON THE METABOLISM OF ANTIPYRINE, PARACETAMOL AND SULPHANILAMIDE IN ISOLATED RAT HEPATOCYTES

British Journal of Anaesthesia (1981)

Håkon Aune Harald Olsen Jørg Mørland

Diethyl ether

10.1093/bja/53.6.621

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Citations (16)

11–Deoxycortisol Induces Hepatic Tryptophan Oxygenase in Rats

Acta Pharmacologica et Toxicologica (1985)

Hallvard Gjerde Grim Gadeholt Harald Olsen Jørg Mørland Nils Norman

Abstract: 11–Deoxycortisol (cortexolone) has previously been used as a glucocorticoid antagonist in vitro and in adrenalectomized rats. Antiglucocorticoid properties of 11–deoxycortisol in intact rats were examined by studying the effect of 11–deoxycortisol on the induction of hepatic tryptophan oxygenase (TO) by corticosterone. No antiglucocorticoid effect was observed. When 11–deoxycortisol was injected into rats, the TO activity increased. This was probably mainly caused by an elevation of the serum corticosterone level. The induction of TO by 11–deoxycortisol was inhibited by metyrapone. However, 11–deoxycortisol (100 mg/ kg) was still not a glucocorticoid antagonist even in presence of metyrapone

Antiglucocorticoid

Metyrapone

Corticosterone

10.1111/j.1600-0773.1985.tb00006.x

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Citations (0)

Ethanol interaction with drug acetylation in vivo and in vitro

Pharmacology Biochemistry and Behavior (1983)

Harald Olsen Jørg Mørland

Procainamide

Sulfanilamide

Sulfadimidine

10.1016/0091-3057(83)90189-2

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Citations (11)

Pharmaceutical-grade albumin: impaired drug-binding capacity in vitro

BMC Clinical Pharmacology (2004)

Harald Olsen Anders Andersen Arve Nordbø Ulf E. Kongsgaard Ole P. Børmer

Digitoxin

Human serum albumin

Serum Albumin

10.1186/1472-6904-4-4

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Citations (61)

Behandling av unge stoffmisbrukere med naltrekson

Tidsskrift for Den Norske Laegeforening (2003)

Helge Waal Øyvin Aamodt Harald Olsen

Source

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Citations (0)

Carisoprodol Elimination in Humans

Therapeutic Drug Monitoring (1994)

Harald Olsen Erling O. Koppang Gunnar Alván Jørg Mørland

The elimination of the muscle relaxant drug, carisoprodol, was examined in 10 healthy volunteers after an oral dose of 700 mg. In nine subjects, carisoprodol was rapidly eliminated, with a mean half-life of 99 ± 46 min, and extensively converted to meprobamate. Within 2.5 h after carisoprodol intake, meprobamate serum concentrations exceeded those of carisoprodol. Serum levels of meprobamate recorded (15–25 μmol/L) indicate that meprobamate might contribute to the effect(s) of carisoprodol. One subject eliminated carisoprodol with an overall half-life of 376 min, and only small amounts of meprobamate were recorded. This subject was found to be a poor metabolizer of mephenytoin. In spiked human sera, protein binding of carisoprodol was in the range of 41–67%, whereas meprobamate was bound to a lesser extent, 14–24%.

Meprobamate

Muscle relaxant

10.1097/00007691-199408000-00001

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Citations (62)

Comorbidities and mortality in relation to asthma severity and exacerbations.

05.01 - Airway pharmacology and treatment (2024)

Arja Viinanen Anton Klåvus Harald Olsen Annina Lyly Mariann I. Lassenius

Asthma Exacerbations

10.1183/13993003.congress-2024.pa1767

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Citations (0)

Do exposure to organic solvents precipitate rheumatic disease?

Clinical Rheumatology (1986)

Roald Omdal Harald Olsen S. R. Berge K. E. Stabell

Rheumatic disease

10.1007/bf02054265

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Citations (1)

Pharmacokinetic analysis of two different docetaxel dose levels in patients with non-small cell lung cancer treated with docetaxel as monotherapy or with concurrent radiotherapy

BMC Cancer (2007)

Paal Brunsvig Anders Andersen Steinar Aamdal Vessela N. Kristensen Harald Olsen

Previous pharmacokinetic studies with docetaxel have mostly used 3-weekly (75 mg/m2 and 100 mg/m2) or weekly regimens (35–40 mg/m2). The pharmacokinetics and radiosensitizing efficacy of weekly 20 mg/m2 docetaxel, has however not been well characterized. We examined the pharmacokinetics of weekly docetaxel when administered with concurrent radiotherapy and compared the results with a 3-weekly 100 mg/m2 regimen. Thirty-four patients with non small cell lung cancer (NSCLC) were included in this study, 19 receiving 100 mg/m2 docetaxel 3-weekly as single therapy, and 15 receiving 20 mg/m2 docetaxel weekly with concurrent radiotherapy. A newly developed HPLC method was used for measuring docetaxel levels, capable of quantifying docetaxel in plasma down to the nanomolar level. The HPLC method showed detectable concentrations of docetaxel in plasma even after 72 hours. In the present study we have demonstrated that median docetaxel plasma levels of 3 nM can be obtained 72 hours after a dose of 20 mg/m2. The pharmacokinetics of docetaxel is characterized by great inter-individual variability and at some time points plasma concentrations for 20 mg/m2 and 100 mg/m2 docetaxel were overlapping. Extrapolation of these results indicates that radio sensitizing docetaxel concentrations may be present for as long as 1 week, thus supporting the use of 20 mg/m2 weekly docetaxel.

Regimen

10.1186/1471-2407-7-197

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Citations (45)