Yoichi Saitoh

National Institutes for Quantum and Radiological Science and Technology

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Harumasa Ohyanagi

Kindai University

Yoshiaki Tabuchi

University of Toyama

Kazumasa Narumi

National Institutes for Quantum and Radiological Science and Technology

Masahiro Yamamoto

Kaiser Permanente San Leandro Medical Center

Tomoaki Urakawa

Asahi Shimbun Company (Japan)

Yonson Ku

Chung Shan Medical University

Yoshikazu Kuroda

Izumi City General Hospital

A. Iwase

Osaka Prefecture University

Yasuyuki Suzuki

Kagawa University

Ayano Chiba

National Institutes for Quantum and Radiological Science and Technology

Cooperative Institutions

The University of Tokyo

Kobe University

Osaka University

Tohoku University

Kyoto University

Nagoya University

Kyushu University

Keio University

Hokkaido University

Chiba University

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A Study of Clinicopathological Findings and Postoperative Survival of Poorly Differentiated Adenocarcinoma of the Stomach in View of Amount of Interstitial Connective Tissue.

The Japanese Journal of Gastroenterological Surgery (1993)

Shirô Kawamura Michio Kato T Morishita Masakazu Ohno Masato FUNASAKA

胃の低分化型腺癌511例を間質結合織の多寡により髄様型 (91例), 中間型 (148例), および硬性型 (272例) に分類し, このうち髄様型と硬性型について臨床病理学的特徴および予後を比較検討した.さらに髄様型ではリンパ球浸潤による術後遠隔成績に関しても検討を加えた.その結果, 髄様型は高齢者, 男性, 胃癌取扱い規約によるA領域, 肉眼型の1, 2型, ps (-), n4, stage Iが多くみられた.一方, 硬性型では若年者, 女性, 全領域に広がるもの, 肉眼型の3, 4型, ps (+), stage IIIが多くみられた.肉眼型腹膜播種および肝転移の頻度は両型間に差はなかった.両型の術後遠隔成績はstage別, ps別に有意差を認めず, 間質量の多寡は予後に影響を及ぼさなかった.しかしながら, 髄様型においてリンパ球浸潤を伴う症例はPS (-) 症例に限ると伴わない症例より予後が良好の傾向を示した.

Gastric adenocarcinoma

10.5833/jjgs.26.1983

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Citations (1)

CLINICAL STUDIES ON ISCHEMIC COLITIS

The journal of the Japanese Practical Surgeon Society (1994)

Hideki IDEI Yoshi NAGAHATA Naoto Kawakita Kazuo Yoshizumi Yoichi Saitoh

For the better pathophysiological understanding of ischemic colitis, a clinical analysis of 24 cases of this disease in a 13-year period from 1979 to 1992 was conducted. The distribution of ages was 19-89 and there were 9 males and 15 females. As to disease type, transient type was noted in 15 cases, stricture type in 5 cases, and gangrenous type in 4 cases. Most of them had some underlying diseases. Eighteen patients had bowel diseases which increased the intraintestinal pressure, and 7 patients had cardiovascular diseases. These patients first manifested abdominal pain or melena in a relatively high frequency. The diagnosis was made mostly based on colonoscopic findings in transient type of patients; barium enema in stricture types; and operative findings in gangrenous types. Conservative treatment was performed in 17 patients, elective operation in 2 patients, and emergency operation in 5 patients. It has been emphasized that ischemic colitis has a close relation with cardiovascular diseases. However, our results suggest that ischemic colitis has a close relation with the increased intralumenal pressure of the bowel as well as cardiovascular disorders.

Melena

Ischemic Colitis

Barium enema

Intestinal Ischemia

10.3919/ringe1963.55.853

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[Experimental study on the developmental mechanism of stress ulcer--especially on changes in PGE2].

PubMed (1986)

Tomayosi Hayasi Tomoaki Urakawa Yoichi Saitoh

A study was made on changes in the gastric mucosal prostaglandin (PGE2) at the time of onset of stress ulcer in view of the association between those changes and the blood flow of the gastric mucosa, and further study was performed on the preventive effect of pGE2 and carboxymethoxy-4,4'-bis (3-methyl-2-butenyloxy) chalcone (hereinafter referred to as SU-88) administered to the enthetic cases. When the control rats were loaded with water immersion stress, a noticeable decline of as much as about 50% was seen in the blood flow of gastric mucosa in 2 hours, and simultaneously a decrease was recognized in the quantity of the gastric mucosal pGE2 approximately 32%. On the other hand, these changes are controlled in the vagotomized rats. In comparison with vagotomized rats, a decline was seen in the gastric mucosal PGE2 while an increase was observed in it in the rats with the vagus nerves stimulated by bethanechol. In the dehemotized (24 ml/kg) rats and the rats loaded with water immersion stress, a decline was seen in the synthesis of the gastric mucosal pGE2. Administration of PGE2 and SU-88 before the loading of stress suppressed an increase in the quantity of the gastric mucosal pGE2 and the blood flow of the gastric mucosa.

Stress ulcer

Bethanechol

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A CASE REPORT OF RESECTED GRANULAR CELL TUMOR OF THE ESOPHAGUS

The journal of the Japanese Practical Surgeon Society (1995)

T Shiraishi Yutaka Hamabe Hajime Ikuta Hiroshi Yoshioka Ryuichiro Ikegawa

This paper describes a case of granular cell tumor of the esophagus removed and diagnosed by endoscopic polypectomy. A 59-year-old man complaining of general fatigue was found having a tumor of the esophagus by X-ray examination of the digestive system at elsewhere and was admitted to the hospital. Gastrointestinal series showed a 17×10mm elevated lesion with a regular edge and sharply demarcated margin at anterior wall of the abdominal portion of the esophagus. Endoscopy disclosed a Yamada III elevated lesion above the EG-junction. From biopsy a diagnosis of granular cell tumor was made. Endoscopic ultrasonography demonstrated a hypoechoic mass with almost homogenous internal echo in the subrmucosa. The tumor was removed with endoscopic polypectomy. In a review of the literature, a total of 82 cases of granular cell tumor of the esophagus were seen. The disease was commonly found in men in their forties or fifties. The half the patients were asymptomatic. The granular cell tumors often occurred in the lower esophagus. These tumors less than 25mm in diameter were treated with endoscopic polypectomy. On the whole, surgical treatment for the tumor has been decreasingly performed.

Granular Cell Tumor

Polypectomy

10.3919/ringe1963.56.967

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Enhancement of fibroblast growth factor‐induced diacylglycerol formation and protein kinase C activation by colon tumor‐promoting bile acid in Swiss 3T3 cells

FEBS Letters (1986)

Yoshifumi Takeyama Tetsuji Tanimoto Masahiko Hoshijima Kozo Kaibuchi Harumasa Ohyanagi

A small amount (50–200 μM) of deoxycholate (DOC), a colon tumor‐promoting bile acid, did not show a direct effect on protein kinase C activity in a cell‐free system, but enhanced fibroblast growth factor (FGF)‐induced diacylglycerol formation and protein kinase C activation in Swiss 3T3 cells. DOC potentiated both reactions induced by submaximal doses of FGF but showed little effect on the maximal levels of the reactions. DOC alone was inactive in eliciting both reactions in the absence of FGF. DOC did not affect the binding of FGF to the cells. Since it has been described that diacylglycerol serves as a messenger for the activation of protein kinase C in the action of FGF in Swiss 3T3 cells [(1985) FEBS Lett. 191, 205‐210], these results suggest that a small amount of DOC increases the sensitivity to FGF of diacylglycerol formation and thereby potentiates protein kinase C activation in this cell line. This action of DOC was in marked contrast to that of 12‐ O ‐tetradecanoylphorbol‐13‐acetate, a potent tumor‐promoting phorbol ester, which directly activated protein kinase C in cell‐free and intact cell systems.

Second messenger system

Phorbol

10.1016/0014-5793(86)80353-2

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Induction of apoptotic cell death by pancreatitis‐associated ascitic fluid in Madin‐Darby canine kidney cells

FEBS Letters (1995)

Junsuke Nishikawa Yoshifumi Takeyama Takashi Ueda Yuichi Hori Nozomi Ueno

We investigated the cytotoxicity on Madin-Darby canine kidney (MDCK) cells of pancreatitis-associated ascitic fluid (PAAF) collected from rats with experimental necrotizing pancreatitis. PAAF reduced viability of MDCK cells in a time- and dose-dependent manner. We detected DNA fragmentation on the PAAF-treated MDCK cells, indicating that the cytocidal action of PAAF is via apoptosis. From the results obtained, we conclude that PAAF contains factor(s) inducing apoptosis on MDCK cells, and we assume that apoptotic cell death is involved in the mechanism of organ failure in acute pancreatitis.

Ascitic fluid

Apoptotic cell death

10.1016/0014-5793(95)00999-p

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Citations (17)

Change in magnetic and structural properties of FeRh thin films by gold cluster ion beam irradiation with the energy of 1.67 MeV/atom

Journal of Applied Physics (2014)

T. Koide Yoichi Saitoh Masako Sakamaki Kenta Amemiya A. Iwase

The effect of energetic cluster ion beam irradiation on magnetic and structural properties of FeRh thin films have been investigated. The cluster ions used in the present studies consist of a few gold atoms with the energy of 1.67 MeV/gold atom. Saturation magnetization of the sample irradiated with Au3 cluster ion beam (280 emu/cc) is larger than that for the irradiated sample with Au1 ion beam (240 emu/cc) for the same irradiation ion fluence. These results can also be confirmed by the X-ray magnetic circular dichroism (XMCD) measurement; the XMCD signal for Au3 cluster ion irradiation is larger than that for Au1 ion irradiation. Since the ion beam irradiation induced magnetization of FeRh is significantly correlated with the amount of the lattice defects in the samples, cluster ion beam irradiation can be considered to effectively introduce the lattice defects in B2-type FeRh rather than the single ion beam. Consequently, cluster ion irradiation is better than single ion irradiation for the viewpoint of saturation magnetization, even if the same irradiation energy is deposited in the samples.

Ion beam mixing

10.1063/1.4864745

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Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain

Diabetes (1992)

K Kawano Tsukasa Hirashima Seijiro Mori Yoichi Saitoh M. Kurosumi

Strain (injury)

10.2337/diabetes.41.11.1422

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Citations (871)

Characterization of an Antigen Defined by Monoclonal Antibody KMO1

Hybridoma (1990)

Yoshiaki Kano T Taniguchi Yahiro Uemura Kazumasa Yokoyama Kunio Uesaka

We have isolated an antigen defined by the monoclonal antibody KMO1 from tissue culture supernatant as a glycoprotein and from cancer cells as a glycolipid. The antigenic determinant was a carbohydrate. Antibody KMO1 inhibited the binding activity of 19-9 to CA19-9, but 19-9 antibody did not inhibited the binding activity of KMO1 to KMO1 antigen. The glycolipid antigen of KMO1 was a monosialoganglioside and was separated into 3 components on thin layer chromatography. The 19-9 antibody reacted with one of the components. These results suggest that the KMO1 antigen is similar to but not identical to CA19-9.

10.1089/hyb.1990.9.363

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De novo expression of aromatase in gastric carcinoma

Pathology - Research and Practice (1992)

Yoichi Saitoh Hironobu Sasano Hiroshi Naganuma Haruo Ohtani Nobuaki Sasano

10.1016/s0344-0338(11)81156-8

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Citations (13)