Qu-Tong Zheng

Hunan University of Traditional Chinese Medicine

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Ji‐Chang Xiao

Shanghai Institute of Organic Chemistry

Jin‐Hong Lin

Shanghai Institute of Organic Chemistry

Yaya Duan

Xuzhou Central Hospital

Zongbao Wang

Ningbo University

Qiuxia Huang

Guilin Medical University

Xing Zheng

Minzu University of China

Xianliang Zeng

Hubei University of Medicine

Xing Zheng

University of South China

Yinxiang Zhang

Fudan University

Xing Zheng

Sun Yat-sen University

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University of South China

Chinese Academy of Sciences

Shanghai Institute of Organic Chemistry

University of Chinese Academy of Sciences

Wuhan University

Huazhong University of Science and Technology

Sichuan University

Sun Yat-sen University

Chinese Academy of Medical Sciences & Peking Union Medical College

Ministry of Education of the People's Republic of China

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CCDC 1545327: Experimental Crystal Structure Determination

The Cambridge Structural Database (2017)

Qiuxia Huang Qu-Tong Zheng Yaya Duan Jin‐Hong Lin Ji‐Chang Xiao

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

10.5517/ccdc.csd.cc1nw18v

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Advances in Research on Pharmacological Activities and Synthesis of Oleanolic Acid Derivatives at C-3 Position

The Natural Products Journal (2015)

Qu-Tong Zheng Yi Liu Hongfei Chen Yan Xiao Xianliang Zeng

Oleanolic acid (3β-hydroxyolean-12-en-28-oic acid) belongs to pentacyclic triterpenoid compounds which are widely found in natural plants. Oleanolic acid and its derivatives possess several promising pharmacological activities. The chemical modifications made in the oleanane backbone mainly at carbons C3, C12 and C28 carboxylic acid, have led to a series of new synthetic oleanane triterpenoids. The Oleanolic acid derivatives at C-3 position exhibited the most potent activity. Here, a review of the advances in research on pharmacological activities and synthesis of Oleanolic acid derivatives at C-3 position are presented. Keywords: C-3 position, oleanolic acid, oleanolic acid derivatives, pharmacological activities, research, synthesis.

Oleanane

10.2174/2210315505666150827214022

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Inhibitory effect of resveratrol and related compounds on the macromolecular synthesis in HL-60 cells and the metabolism of 7,12-dimethylbenz[a]anthracene by mouse liver microsomes.

B. D. Dubash Bodan Zheng C. H. Kim Kangning He Ying Shao

7,12-Dimethylbenz[a]anthracene

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Advances in Research on Hepatoprotective Activity and Synthesis of Oleanolic Acid Derivatives

Journal of Applied Biopharmaceutics and Pharmacokinetics (2015)

Xing Zheng Qu-Tong Zheng Shaowei Bo Xianliang Zeng Yun Wei

Oleanolic acid (3b-hydroxyolean-12-en-28-oic acid) is a pentacyclic triterpenoid compound with a wide spread occurrence throughout the plant kingdom. During the last decade many research articles associated with oleanolic acid have been published. Particularly its hepatoprotective activity has been studied for many years. However, the clinical application of oleanolic acid has been limited by its poor solubility. In order to overcome this disadvantage, various approaches have been sought and many derivatives of oleanolic acid have been designed and synthesized. And some of these analogues show improved pharmacokinetic and pharmacodynamic properties, indicating that it may be promising candidates for the treatment of human liver diseases

10.14205/2309-4435.2015.03.01.4

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Synthesis and Anti-thyroid Cancer Effect of Iodo-chrysin Derivatives

Medicinal Chemistry (2015)

Yun Wei Qu-Tong Zheng Guotao Tang Chen Song Guan Wang

A novel series of iodo-chrysin derivatives with resorcinol as raw materials were synthesized according to Baker-Venkataraman reaction and their inhibitory activities in vitro against thyroid cancer cell lines (SW-579 and TT) were evaluated by the standard methyl thiazole tetrazolium (MTT) method. Biological test results showed that these derivatives possessed stronger anti-thyroid cancer activities than 5-FU. Compound 21 showed the strongest activity against SW-579 cell lines with IC50 value of 3.4μM and compound 10 showed the strongest activity against TT cell lines with IC50 value of 6.2μM, it was better than 5-FU (59.3μΜ, 18.4μM respectively).

Chrysin

Thiazole

Cancer cell lines

MTT assay

IC50

10.2174/1573406411666150921111220

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Synthesis and Anti-Cancer Activities of Resveratrol Derivatives

Open Journal of Medicinal Chemistry (2016)

Xing Zheng Liu‐Ying Yu Xu Yao Bo Lv Zehua Yang

A novel series of resveratrol derivatives were synthesized according to Wittig-Horner reaction with 3,5-dihydroxybenzyl alcohol or 3,5-dimethoxybenzyl alcohol or 4-hydroxybenzyl alcohol as raw material and the inhibitory activities on breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) in vitro were evaluated by the standard methyl thiazole tetrazolium (MTT) method. The result of biological test shows that some of resveratrol derivatives possess stronger anti-cancer activities than 5-FU. Compound 5c shows the strongest activity against breast carcinoma (MDA-MB-231) and gastric carcinoma cell lines (SGC-7901) with IC50 value of 50.19 ± 1.02 μM, 122.68.27 ± 2.04 μM, compared to that IC50 value of 5-FU is 98.59±3.61 μM,156.74±6.16 μM, respectively.

Thiazole

IC50

Breast carcinoma

Carcinoma Cell

10.4236/ojmc.2016.63005

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Synthesis and antioxidant activity of curcumin analogs

Journal of Asian Natural Products Research (2016)

Qu-Tong Zheng Zehua Yang Liu‐Ying Yu Yuyan Ren Qiuxia Huang

Numerous biological activities including antioxidant, antitumor, anti-inflammation, and antivirus of the natural product curcumin were reported. However, the clinical application of it was significantly limited by its instability, poor solubility, less body absorbing, and low bioavailability. This review focuses on the structure modification and antioxidant activity evaluation of curcumin. To study the structure–activity relationship (SAR), five series of curcumin analogs were synthesized and their antioxidant activity were evaluated in vitro. The results showed that electron-donating groups, especially the phenolic hydroxyl group are an essential component to improve the antioxidant activity.

Natural product

10.1080/10286020.2016.1235562

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Ph₃P/ICH₂CH₂I-promoted reductive deoxygenation of alcohols

Organic & Biomolecular Chemistry (2023)

Wen-Huan Tang Xing Zheng Xu Yao Jin‐Hong Lin Qu-Tong Zheng

Owing to the ubiquity of the hydroxyl group, reductive deoxygenation of alcohols has become an active research area. The classic Barton-McCombie reaction suffers from a tedious two-step procedure. New efficient methods have been developed, but they have some limitations, such as a narrow substrate scope and the use of moisture-sensitive Lewis acids. In this work, we describe the Ph3P/ICH2CH2I-promoted reductive deoxygenation of alcohols with NaBH4. The process is applicable to benzyl, allyl and propargyl alcohols, and also to primary and secondary alcohols, demonstrating a wide substrate scope and a good level of functional group tolerance. This protocol features convenient operation and low cost of all reagents.

Deoxygenation

Reductive elimination

Propargyl

Scope (computer science)

10.1039/d3ob01698f

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CCDC 1418098: Experimental Crystal Structure Determination

The Cambridge Structural Database (2017)

Qiuxia Huang Qu-Tong Zheng Yaya Duan Jin‐Hong Lin Ji‐Chang Xiao

10.5517/ccdc.csd.cc1jln3w

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Pharmacological activities and structure-modification of resveratrol analogues.

PubMed (2015)

Yan Xiao Hongfei Chen Song Chen Xianliang Zeng Qu-Tong Zheng

Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a well-known natural polyphenol compound. It is reported that resveratrol possesses strong anti-oxidative, anti-inflammatory, cardiovascular protective and cancer chemo-preventive effects. Therefore, there has been a considerable interest in its biological activity, pharmacological activity and also synthetic resveratrol analogues in recent years. Up to now, many new resveratrol derivatives have been synthesized and some new biological activities of these compounds have been found, so in the treatment of Alzheimer's disease and the inhibition of influenza H1N1 neuraminidase. Structure-activity studies revealed that crucial elements of parental components are required for specific effects. This review summarizes the available literatures on the structure-activity relationships and pharmacological properties of resveratrol analogues.

Structure–activity relationship

Natural compound

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Citations (15)