Z. Wu

The University of Texas Health Science Center at Houston

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Qing Yang

The University of Texas Medical Branch at Galveston

Edgar T. Walters

The University of Texas Health Science Center at Houston

Qi You

China Pharmaceutical University

Qing Guo

Xuzhou Medical College

Li Zhao

Kunming University of Science and Technology

Robyn J. Crook

San Francisco State University

Kate Ching‐Ju Lin

National Yang Ming Chiao Tung University

Trevor C. Chen

Taipei Veterans General Hospital

S. Carlton

Columbia University Irving Medical Center

Jen‐Ping Chen

University of California, Riverside

Cooperative Institutions

The University of Texas Health Science Center at Houston

China Pharmaceutical University

The University of Texas Medical Branch at Galveston

National Yang Ming Chiao Tung University

National Taiwan University

Taipei Veterans General Hospital

Baylor College of Medicine

The University of Texas MD Anderson Cancer Center

The University of Texas at Austin

Fudan University

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Gambogic acid inducing apoptosis in human gastric adenocarcinoma SGC-7901 cells

Chinese Journal of Natural Medicines (2004)

Qing Guo Li Zhao Qi You Z. Wu Hong Gu

Gambogic acid

Gastric adenocarcinoma

MTT assay

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Citations (12)

Persistent Pain after Spinal Cord Injury Is Maintained by Primary Afferent Activity

Journal of Neuroscience (2014)

Qing Yang Z. Wu Julia K. Hadden Max A. Odem Yongchun Zuo

Chronic pain caused by insults to the CNS (central neuropathic pain) is widely assumed to be maintained exclusively by central mechanisms. However, chronic hyperexcitablility occurs in primary nociceptors after spinal cord injury (SCI), suggesting that SCI pain also depends upon continuing activity of peripheral sensory neurons. The present study in rats (Rattus norvegicus) found persistent upregulation after SCI of protein, but not mRNA, for a voltage-gated Na⁺ channel, Nav1.8, that is expressed almost exclusively in primary afferent neurons. Selectively knocking down Nav1.8 after SCI suppressed spontaneous activity in dissociated dorsal root ganglion neurons, reversed hypersensitivity of hindlimb withdrawal reflexes, and reduced ongoing pain assessed by a conditioned place preference test. These results show that activity in primary afferent neurons contributes to ongoing SCI pain.

Premovement neuronal activity

10.1523/jneurosci.5316-13.2014

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Brain dysfunction explored by long latency reflex: a study of adrenomyeloneuropathy

Acta Neurologica Scandinavica (2001)

Ke Liao Jen‐Ping Chen Kate Ching‐Ju Lin Trevor C. Chen Kuo-Hsing Kao

Objectives– We can assess brain function by measuring the cortical relay time (CRT) of long latency reflex (LLR) of hand muscle. We would study if measurement of CRT of LLR can explore the brain involvement of adrenomyeloneuropathy (AMN). Methods– Two AMN patients were included in the study. Both of them had spastic gait and mild sensory deficits but normal mental function. The LLRs were provoked at the first dorsal interosseous muscle by electrical stimulation of the middle finger. We measured the latency of LLR and its CRT. Results– Delayed LLR and prolonged CRT were noted in AMN patients, even though the magnetic resonance imaging of brain did not show any significant abnormalities. Conclusions– Measuring CRT of LLR reveals brain involvement of AMN patients, and it is an adjunct in the assessment of brain function though without specific anatomic diagnosis.

H-reflex

10.1034/j.1600-0404.2001.104002105.x

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Citations (4)

Opening of KCNQ/Kv7 channels blocks both spontaneous activity in small DRG neurons and signs of chronic pain after spinal cord injury

Journal of Pain (2013)

Qing Yang Z. Wu Jing Du Robyn J. Crook S. Carlton

Nociceptor

10.1016/j.jpain.2013.01.552

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Citations (1)

Mutational analysis of integrase and excisionase proteins in bacteriophage lambda site-specific recombination system